A5101751880- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Effects of Radiation Exposure
- Ferroptosis and cancer prognosis
- Multiple Myeloma Research and Treatments
- Chromosomal and Genetic Variations
- Cytokine Signaling Pathways and Interactions
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic diversity and population structure
- Reconstructive Surgery and Microvascular Techniques
GlaxoSmithKline (United States)
2022-2025
Huazhong University of Science and Technology
2019-2025
Hubei Cancer Hospital
2014-2025
Union Hospital
2024
Huazhong University of Science and Technology Hospital
2023
AstraZeneca (United States)
2019-2023
Shenzhen University Health Science Center
2023
Shenzhen University
2022
Henan University of Science and Technology
2022
Wannan Medical College
2021
Abstract The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment 171) ctDNA samples across 16 advanced-stage types from three phase I/II trials durvalumab (± the anti-CTLA4 therapy tremelimumab). Higher variant allele frequencies (VAF) were associated poorer overall survival (OS) other known prognostic factors, but not objective response, suggesting role...
Tibetans are well adapted to the hypoxic environments at high altitude, yet molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with strongest signal selection in previous genome-wide scans Tibetans. showed that Tibetan-enriched EPAS1 variants down-regulate expression human umbilical endothelial cells placentas. Heterozygous knockout mice display blunted physiological...
4520 Background: In aBTC, GemCis is the standard of care as 1 st -line treatment. Immunotherapies have shown early promising efficacy in some BTC patients (pts). We assessed D (anti-PD-L1) ± T (anti-CTLA-4) and 1L pts, including an extensive biomarker analysis (NCT03046862). Methods: Pts were first enrolled cohort (BMC) to receive cycle Gem 1000 mg/m 2 + Cis 25 on D1 & D8, followed by 1120 mg 75 mg, Q3W until disease progression (PD). Subsequent pts allocated (3 combo [3C]) or D+T (4...
Intronic DNA is a major component of eukaryotic genes and genomes can be subject to selective constraint have functions in gene regulation. Intron size particular interest given that it thought the target variety evolutionary forces has been suggested linked ultimately various phenotypic traits, such as powered flight. Using whole-genome analyses comparative approaches account for phylogenetic nonindependence, we examined interspecific variation intron three data sets encompassing from 12 30...
Yak is one of the largest native mammalian species at Himalayas, highest plateau area in world with an average elevation >4,000 m above sea level. well adapted to high altitude environment a set physiological features for more efficient blood flow oxygen delivery under hypobaric hypoxia. Yet, genetic mechanism underlying its adaptation remains elusive. We conducted cross-tissue, cross-altitude, and cross-species study characterize transcriptomic landscape domestic yaks. The generated...
Circular RNAs (circRNAs) are considered to be highly stable due the closed structure, which predominately correlated with development and progression of a wide variety cancers. Colon cancer is one most common malignancies worldwide. A recent study demonstrated upregulated expression circPIP5K1A in non-small cell lung cancer. However, few studies have investigated relationship between circ_0014130 level colon Therefore, elucidating underlying mechanisms circPIP5K1A's role may help...
Radiation therapy is an important treatment approach for esophageal squamous cell carcinoma (ESCC). However, how to promote radiation sensitivity in ESCC remains a challenge. This study aimed evaluate the effects of berberine, common used Chinese medicine, on radiosensitivity ESCC. ECSS line ECA109 and TE13 were subjected hypoxia and/or ionizing (IR), presence or absence berberine treatment. Cell growth survival, apoptosis evaluated. In addition, cells xenografted into nude mice IR The...
The radiation resistance of prostate cancer remains the primary obstacle to improve patient survival. This study aimed investigate effects berberine, a commonly used natural product, on radiosensitivity cancer.Prostate cell line LNCaP and DU-145 were subjected hypoxia and/or ionizing (IR), in presence or absence berberine treatment. Cell growth colony formation, apoptosis evaluated. Moreover, cells xenografted into nude mice IR expression HIF-1α VEGF xenografts was detected by Western blot...
The radioresistance of esophageal squamous cell carcinoma (ESCC) remains an obstacle for the effective radiotherapy ESCC. This study aimed to investigate radiosensitization ESCC by signal transducer and activator transcription 3 (STAT3) inhibitor stattic. ECA109, TE13, KYSE150 lines were exposed hypoxia treated with stattic or radiation, alone in combination. Cell proliferation, colony formation, apoptosis, double-stranded DNA breaks (DSBs) examined. In addition, ECA109 cells xenografted...
Abstract Purpose: Biomarkers that predict response to immune checkpoint inhibitors (ICI) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) are needed. This retrospective study assessed tumor mutational burden (TMB) outcomes the phase II HAWK CONDOR III EAGLE studies of durvalumab with without tremelimumab platinum-resistant R/M HNSCC. Patients Methods: Tumor samples from HAWK/CONDOR (N = 153) blood 247) were analyzed for TMB. Associations survival evaluated tissue...
Acute appendicitis is one of the most common acute abdominal conditions in clinic, and characterized by an onset, severe symptoms, rapid progression [1]. Currently, endoscopic retrograde therapy (ERAT) emerging treatment method for appendicitis, which involves colonoscopically guided intubation appendix, drainage pus, imaging to clarify diagnosis, flushing lumen, placement drainage, so on, relieve obstruction reduce pressure appendiceal lumen [2]. ERAT has advantages less trauma, shorter...
Background The association between oxidative stress, as measured by the Oxidative Balance Score (OBS), and sleep quality remains unclear. primary objective of this investigation was to clarify relationship explore potential involvement stress inflammation. Methods Data from 15,198 participants in National Health Nutrition Examination Survey 2007–2014 were analyzed. Sleep indicators, including disorder, trouble, duration, assessed. OBS, comprising information on 16 dietary nutrients 4...
The prevalence of metabolic syndrome (MetS) among middle-aged and older individuals in the U.S. is rising, posing significant mortality risks. Diet a key factor MetS development, yet few studies have examined combined effects dietary lifestyle factors on this group. Recently, oxidative balance score (OBS), an indicator status encompassing diet physical activity, has attracted interest. This study explores association between OBS MetS, as well its individual components, Americans. Data from...
Pulmonary arterial intimal sarcoma (PAIS) is a rare malignant mesenchymal tumor often associated with an unfavorable prognosis and lacks standardized treatment approach to date. This report presents notable case of PAIS treated neoadjuvant therapy involving anlotinib concomitantly administered chemotherapy ifosfamide pirarubicin, which resulted in favorable outcome. A 38-year-old man was admitted our hospital chest tightness, cough, dyspnea, all had persisted for more than week. Initial...
Abstract Purpose: Understanding the mutational landscape of recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is important in identifying biomarkers to determine which patients may benefit from immune checkpoint inhibitors (ICIs). Patients Methods: The HAWK (NCT02207530), CONDOR (NCT02319044), EAGLE (NCT02369874) studies evaluated R/M HNSCC treatment with durvalumab or durvalumab-tremelimumab. Tumor tissue samples pooled HAWK/CONDOR (n=153) plasma cell-free DNA (n=285)...
Abstract Purpose: MEDI3726 is an antibody–drug conjugate targeting the prostate-specific membrane antigen and carrying a pyrrolobenzodiazepine warhead. This phase I study evaluated monotherapy in patients with metastatic castration-resistant prostate cancer after disease progression on abiraterone and/or enzalutamide taxane-based chemotherapy. Patients Methods: was administered at 0.015–0.3 mg/kg intravenously every 3 weeks until progression/unacceptable toxicity. The primary objective to...
Abstract Purpose: Endocrine-based therapy is the initial primary treatment option for hormone receptor–positive and human epidermal growth factor receptor 2-negative (HR+/HER2−) metastatic breast cancer (mBC). However, patients eventually experience disease progression due to resistance endocrine therapy. Molibresib (GSK525762) a small-molecule inhibitor of bromodomain extraterminal (BET) family proteins (BRD2, BRD3, BRD4, BRDT). Preclinical data suggested that combination molibresib with...
In our study we investigated the radioprotective effect of resveratrol (RES) in a murine model radiation-induced salivary gland dysfunction.Ninety-six Institute Cancer Research mice were randomly divided into four groups: solvent (group I), RES treated II; 20 mg/kg/d), 15 Gy irradiation with treatment III), and IV; mg/kg/d RES). II IV) was administered intraperitoneally 3 days prior to through conclusion experiment.Saliva submandibular tissues obtained for biochemical, morphological,...
The transcriptome complexity in an organism can be achieved by alternative splicing of precursor messenger RNAs. It has been revealed that alternations mRNA play important role a number diseases including human cancers.
Radiotherapy is the main therapy for inoperable and locally advanced esophageal squamous cell carcinoma (ESCC). However, radioresistance in ESCC remains a challenge. The aim of this study to investigate radiosensitizing effects STAT3 inhibitor NSC74859 on explore underlying mechanisms. ECA109 TE13 cells were exposed hypoxia, treated with or radiation, alone combination. Cell proliferation, survival, apoptosis, double-stranded DNA breaks (DSBs) examined. Nude mice model xenograft was...
6511 Background: In NSCLC, bTMB assessed from circulating tumor DNA shows promise as a predictive survival biomarker for immunotherapy, but its value in R/M HNSCC is uncertain. We evaluated predictor of HNSCC. Methods: EAGLE (NCT02369874) was randomized, open-label, phase 3 trial evaluating D (anti-PD-L1), or D+T (anti-CTLA-4), vs CT Patients (pts) with disease progression after platinum-based were randomized (1:1:1) to (10 mg/kg intravenous [IV] every 2 weeks [Q2W]), (20 IV Q4W) + T (1 Q4W...
Berberine confers radiosensitivity on nasopharyngeal carcinoma (NPC) and this is associated with the down-regulation of hypoxia-inducible factor-1α (HIF-1α) vascular endothelial growth factor (VEGF) expression. could be a promising radiosensitizer for NPC radiotherapy.NPC has poor prognosis. Radiotherapy as first-line therapy significantly increases patient survival but radioresistance problem. This study aimed to investigate radiosensitizing effects berberine explore underlying...
The accumulation of somatic mutations in genes and molecular pathways is a major factor the evolution oral squamous cell carcinoma (OSCC), which sparks studies to identify with clinical potentials. Recently, massively parallel sequencing technique has started revolutionize biomedical studies, due rapid increase its throughput drop cost. Hence whole transcriptome (RNA-Seq) becomes superior approach cancer enables detection accurate measurement gene expression simultaneously. We used RNA-Seq...