A5100462578- Plant Virus Research Studies
- Plant Molecular Biology Research
- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- High Altitude and Hypoxia
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Photosynthetic Processes and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Plant-Microbe Interactions and Immunity
- Genetic Mapping and Diversity in Plants and Animals
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Insect Resistance and Genetics
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Plant Gene Expression Analysis
- Plant Disease Resistance and Genetics
- Genomics and Phylogenetic Studies
- Insect-Plant Interactions and Control
- Cancer, Hypoxia, and Metabolism
- Polysaccharides and Plant Cell Walls
- Seed Germination and Physiology
Beijing Academy of Agricultural and Forestry Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
State Forestry and Grassland Administration
2025
University of Science and Technology of China
2025
Shenzhen Bao'an District People's Hospital
2025
Sanya University
2023-2025
Chinese Academy of Sciences
2015-2024
University of Chinese Academy of Sciences
2012-2024
ZheJiang Academy of Agricultural Sciences
2011-2024
Renmin Hospital of Wuhan University
2023-2024
Abstract Cattle domestication and the complex histories of East Asian cattle breeds warrant further investigation. Through analysing genomes 49 modern eight ancient samples, worldwide are consistently classified into five continental groups based on Y-chromosome haplotypes autosomal variants. We find that populations mainly composed three distinct ancestries, including an earlier taurine ancestry reached China at least ~3.9 kya, a later introduced Eurasian ancestry, novel Chinese indicine...
Inflammasomes are involved in gut homeostasis and inflammatory pathologies, but the role of NLRP3 inflammasome these processes is not well understood. Cryopyrin-associated periodic syndrome (CAPS) patients with mutations have autoinflammation skin, joints, eyes, intestine. Here we show that intestines CAPS model mice carrying an Nlrp3 R258W mutation maintain gut. Additionally, such strongly resistant to experimental colitis colorectal cancer; this mainly through a remodelled microbiota...
Constitutive activation of plant immunity is detrimental to growth and development. Here, we uncover the role a long non-coding RNA (lncRNA) in fine-tuning balance growth. We find that lncRNA termed salicylic acid biogenesis controller 1 (SABC1) suppresses promotes healthy plants. SABC1 recruits polycomb repressive complex 2 its neighboring gene NAC3, which encodes NAC transcription factor, decrease NAC3 via H3K27me3. activates isochorismate synthase (ICS1), key enzyme catalyzing (SA)...
Tibetans live on the highest plateau in world, their current population size is approximately 5 million, and most of them at an altitude exceeding 3,500 m. Therefore, Tibetan Plateau a remarkable area for cultural biological studies human history. However, chronological profile Plateau’s colonization remains unsolved question prehistory. To reconstruct prehistoric demographic history modern humans Plateau, we systematically sampled 6,109 individuals from 41 geographic populations across...
Tibetans are well adapted to the hypoxic environments at high altitude, yet molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with strongest signal selection in previous genome-wide scans Tibetans. showed that Tibetan-enriched EPAS1 variants down-regulate expression human umbilical endothelial cells placentas. Heterozygous knockout mice display blunted physiological...
Abstract Broomcorn millet ( Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, ensure food security. Here we present genetic variations, population structure diversity of a diverse worldwide collection 516 broomcorn genomes. Population analysis indicated that domesticated originated from its wild progenitor in China. We then constructed graph-based pangenome based on long-read de novo genome assemblies 32 representative accessions. Our...
Abstract Background Glioblastoma stem cells (GSCs) and their exosomes (exos) are involved in shaping the immune microenvironment, which is important for tumor invasion recurrence. However, studies involving GSC-derived exosomal circular RNAs (GDE-circRNAs) regulating microenvironment (TME) remain unknown. Here, we comprehensively evaluated significance of a novel immune-related GDE-circRNA glioma microenvironment. Methods GDE-circPRKD3 was screened out through high-throughput sequencing...
Increased interest in using zebrafish as a model organism has led to resurgence of fin regeneration studies. This allowed for the identification large number gene families, including signaling molecules and transcription factors, which are expressed during regeneration. However, cases where no specific inhibitor is available product interest, determination functional role these genes been difficult. Here we demonstrate that vivo electroporation morpholino oligonucleotides feasible approach...
Abstract The actin cytoskeleton is an important regulator of cell expansion and morphogenesis in plants. However, the molecular mechanisms linking to these processes remain largely unknown. Here, we report functional analysis rice (Oryza sativa) FH5 /BENT UPPERMOST INTERNODE1 (BUI1), which encodes a formin-type nucleation factor affects plant rice. bui1 mutant displayed pleiotropic phenotypes, including bent uppermost internode, dwarfism, wavy panicle rachis, enhanced gravitropic response....
Yak is one of the largest native mammalian species at Himalayas, highest plateau area in world with an average elevation >4,000 m above sea level. well adapted to high altitude environment a set physiological features for more efficient blood flow oxygen delivery under hypobaric hypoxia. Yet, genetic mechanism underlying its adaptation remains elusive. We conducted cross-tissue, cross-altitude, and cross-species study characterize transcriptomic landscape domestic yaks. The generated...
RH6, RH8, and RH12 are previously unidentified D-body components drive the formation of D-bodies through LLPSs.
Abstract Background Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide pathogenic to mosquitoes but harmless the environment. Results We found microRNA (miRNA) can modulate antifungal immunity of Aedes aegypti by inhibiting its cognate serine protease. Fungal infection induce expression modular protease (ModSP), and ModSP knockdown were more sensitive B. infection. novel miRNA-novel-53 linked immune response was...
Abstract Background Survival to cold stress in insects living temperate environments requires the deployment of strategies that lead physiological changes involved freeze tolerance or avoidance. These may consist of, for instance, induction metabolic depression, accumulation cryoprotectants, production antifreeze proteins, however, little is known about way such mechanisms are regulated and signals their activation. Ascarosides signaling molecules usually regulate nematode behavior...
Fibroblast-like synoviocytes (FLSs) contribute to inflammation and joint damage in rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs relapse remission RA remain unknown. Identifying FLS heterogeneity their underlying pathogenic roles may lead discovering novel disease-modifying antirheumatic drugs.
Two-dimensional covalent organic frameworks (2D COFs), a family of crystalline materials with abundant porous structures offering nanochannels for molecular transport, have enormous potential in the applications separation, energy storage, and catalysis. However, 2D COFs remain limited by relatively large pore sizes (>1 nm) weak interlayer interactions between nanosheets, making it difficult to achieve efficient membranes meet selective sieving requirements water molecules (0.3 hydrated salt...
Most plant viruses depend on vector insects for transmission. Upon viral infection, virus-derived small interfering RNAs (vsiRNAs) can target both and host transcripts. Rice stripe virus (RSV) is a persistent-propagative transmitted by the brown planthopper (Laodelphax striatellus, Fallen) cause severe disease rice. To investigate how vsiRNAs regulate gene expressions in insect vector, we analyzed expression profiles of (sRNAs) mRNAs RSV-infected rice planthopper. We obtained 88,247 that...
Abstract Members of the MYB superfamily act as regulators in a wide range biological processes plants. Despite this, from Orchidaceae has not been identified, and genes related to bioactive water-soluble polysaccharide (WSP) biosynthesis are relatively unknown. In this study, we identified 159 165 two orchids, Phalaenopsis equestris Dendrobium officinale , respectively. The proteins were classified into four classes both orchids: MYB-related (MYBR), R2R3-MYB, 3R-MYB atypical proteins. MYBR...