A5010742701- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Health Systems, Economic Evaluations, Quality of Life
- Genomics and Rare Diseases
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Genetic factors in colorectal cancer
- Erythrocyte Function and Pathophysiology
- Education and Public Policy
- Natural product bioactivities and synthesis
- Financial Distress and Bankruptcy Prediction
- Pharmaceutical Economics and Policy
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Financial Reporting and Valuation Research
- Plant Toxicity and Pharmacological Properties
- Malaria Research and Control
- Immune Response and Inflammation
- Auditing, Earnings Management, Governance
- Genomics, phytochemicals, and oxidative stress
- Neurological and metabolic disorders
Instituto Politécnico de Leiria
2022
Inserm
2021
Technologies pour la Santé
2021
Institut Pasteur
2011-2016
Centre National de la Recherche Scientifique
2013-2016
De Montfort University
2015
Universidade do Porto
2011-2014
Homeostasis of lymphocyte numbers is believed to be due competition between cellular populations for a common niche restricted size, defined by the combination interactions and trophic factors required cell survival. Here we propose new mechanism: homeostasis could also achieved ability lymphocytes perceive density their own populations. Such mechanism would reminiscent primordial quorum sensing systems used bacteria, in which some bacteria sense accumulation bacterial metabolites secreted...
Many species of bacteria use quorum sensing to sense the amount secreted metabolites and adapt their growth according population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. investigated regulation size interleukin-2 (IL-2)–producing CD4+ T cell (IL-2p) pool using different IL-2 reporter mice. found that absence either or regulatory (T reg) cells, number IL-2p cells increases. Administration decreases subset and, pertinently, abrogates ability produce...
T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state anergy. Here, we ask whether microRNAs affect the interpretation TCR signaling. We find that Dicer-deficient CD4 cells fail to correctly discriminate between activating and anergy-inducing stimuli produce IL-2 in absence co-stimulation. Excess production by was sufficient override anergy induction WT restore inducible Foxp3 expression Il2-deficient cells. Phosphorylation Akt on S473 S6...
The multifactorial origin of gastric cancer encompasses environmental factors mainly associated with diet. Pteridium aquilinum-bracken fern-is the only higher plant known to cause in animals. Its carcinogenic toxin, ptaquiloside, has been identified milk cows and groundwater. Humans can be directly exposed by consumption plant, contaminated water or milk, spore inhalation. Epidemiological studies have shown an association between bracken exposure cancer. In present work, genotoxicity P....
Plasmodium falciparum is transmitted from humans to Anopheles mosquito vectors via the sexual erythrocytic forms termed gametocytes. Erythrocyte filtration through microsphere layers (microsphiltration) had shown that circulating gametocytes are deformable. Compounds reducing gametocyte deformability would induce their splenic clearance, thus removing them blood circulation and blocking malaria transmission. The hand-made, single-sample prototype for microsphiltration was miniaturized a...
We investigated the ability of monoclonal B cells to restore primary and secondary T-cell dependent antibody responses in adoptive immune-deficient hosts. Priming induced cell activation expansion, AID expression, production generation IgM+IgG- IgM-IgG+ antigen-experienced B-cell subsets that persisted lymphopenic environment by division. Upon transfer recall responded antigen-specific IgG while IgM+ memory secreted mainly IgM little IgG, but generated new expressing germinal center markers....
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