A5100643036- Parkinson's Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Metabolism, Diabetes, and Cancer
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Food Quality and Safety Studies
- Hepatitis C virus research
- Natural Products and Biological Research
- Medical Research and Treatments
- Genetic factors in colorectal cancer
- Autophagy in Disease and Therapy
- Healthcare and Venom Research
- Ecology and Conservation Studies
- IgG4-Related and Inflammatory Diseases
- Nuclear Receptors and Signaling
- Polyamine Metabolism and Applications
- Animal Virus Infections Studies
- Biocrusts and Microbial Ecology
- Mast cells and histamine
- Traditional Chinese Medicine Studies
- Skin Protection and Aging
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
Texas A&M University
2023
Yonsei University
2023
Sungkyunkwan University
2015-2022
Samsung (South Korea)
2015-2022
University Hospital of Basel
2019-2022
University of Basel
2019-2022
Hallym University
2019
Seoul National University
2019
Daegu Fatima Hospital
2018
Samsung Medical Center
2017
Abstract Background Human respiratory syncytial virus (hRSV) is a leading cause of severe lower infection and major public health threat worldwide. To date, no vaccine or effective therapeutic agent has been developed. In screen for potential agents against hRSV, we discovered that an extract Rosmarinus officinalis exerted strong inhibitory effect hRSV infection. Subsequent studies identified carnosic acid as bioactive constituent responsible anti-hRSV activity. Carnosic shown to exhibit...
Farnesol enhances the amounts of farnesylated PARIS and PGC-1α, preventing dopaminergic neuronal loss in Parkinson’s disease models.
Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the neuromuscular junction (NMJ). The most common autoantibody target acetylcholine receptor (AChR). Three mechanisms have been postulated which autoantibodies might interfere neurotransmission: direct antagonism receptor, complement-mediated destruction postsynaptic membrane, enhanced internalization receptor. It very likely that more than one these act in...
Progressive dopaminergic neurodegeneration is responsible for the canonical motor deficits in Parkinson's disease (PD). The widely prescribed anti-diabetic medicine metformin effective preventing animal models; however, despite significant potential of treating PD, therapeutic effects and molecular mechanisms underlying neuroprotection by are largely unknown.In this study, we found that induced substantial proteomic changes, especially metabolic mitochondrial pathways substantia nigra (SN)....
Edelweiss (Leontopodium Alpinum) in the family Asteraceae is a wildflower that grows rocky limestone places. Here, we investigated efficacy of edelweiss callus culture extract Alpinum extract; LACCE) using multiple assays from vitro to vivo as well transcriptome profiling. Several assay results showed strong antioxidant activity LACCE response UVB treatment. Moreover, suppressed inflammation and wrinkling; however, moisturizing was increased by LACCE. The clinical test demonstrated constant...
Hepatitis B virus (HBV) infection is associated with a broad spectrum of clinical manifestations, including cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress subsequent oxidative have been implicated in liver carcinogenesis disease progression chronic inflammation. In our previous study, several mutations the precore/core region HBV genotype C were identified from 70 Korean patients, HCC and/or e antigen serostatus. Here, we found that naturally occurring...
Purpose: Profibrotic activation is essential for pterygium development. In this study, we investigated the role of mechanistic target rapamycin (mTOR) in regulating TGF-β1-induced myofibroblastic responses human fibroblasts (HPFs) and elucidated relative contributions mTOR signaling components. Methods: HPFs were pretreated with inhibitors Torin2, expression profibrotic markers, including α-smooth muscle actin (α-SMA) fibronectin, was evaluated. RNA interference-based approaches targeting...
Determining antigen specificity is vital for understanding B cell biology and producing human monoclonal antibodies. We describe here a powerful method identifying cells that recognize membrane antigens expressed on cells. The technique depends two characteristics of the interaction between an antigen-expressing cell: antigen-receptor-mediated extraction from target cell, activation. developed using influenza hemagglutinin as model viral antigen, tested it acetylcholine receptor (AChR)...
Human Respiratory Syncytial virus (hRSV) is a leading cause of severe lower respiratory tract diseases in the pediatric population. RSV frequently causes morbidity and mortality high risk groups including infants with congenital heart disease immunosuppressed patients. Although hRSV recognized as major public health threat economic burden worldwide, there no licensed vaccine effective therapeutic agent. Viral nonstructural (NS) proteins have been known to play multiple functions for...
Thyroid dysfunction has been reported to be an extrapulmonary symptom of COVID-19. It is important identify the tissue subset that expresses angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine (TMPRSS2), which are essential for host infection with severe acute respiratory syndrome coronavirus (SARS-CoV-2), in order understand viral pathogenesis COVID-19-related thyroid dysfunction. We investigated expression distribution ACE2- TMPRSS2-expressing cells gland. RT-PCR...
Background/Aims: Non-tuberculous Mycobacterium (NTM) infections usually result in chronic disease, and making a diagnosis is often difficult.Skin soft tissue due to NTM are not common diagnosed relatively late.We investigated the clinical characteristics of nine cases skin with NTM.Methods: Nine patients an infection who were confirmed consecutively by and/or adjacent bone cultures at teaching hospital between August 2006 July 2013 enrolled this study.The demographics, characteristics,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Objectives: Tobacco use remains a leading cause of preventable death in the United States, and relapse rates among those who quit smoking are alarmingly high. Personal networks (PNs) substantially influence quitting behaviors but have not been incorporated into prevention approaches. Thus, we carried out pilot study employing PNs measured changes participants′ PNs. Methods: This was single-group pre-post intervention where participants received Helpers Stay Quit (HSQ), behavioral designed to...
Abstract Midlife women experience a wide range of menopausal symptoms. Such symptoms may be different in midlife who are family caregivers persons living with chronic disease, particularly Alzheimer’s disease. Because the cultural stigma dementia differs among racial/ethnic minority groups, tend to feel burdened caregiving and report negative health outcomes compared White women. This study aimed explore differences symptom experienced by were disease (MWPLAD). A secondary data analysis was...