A5050837231- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Cleft Lip and Palate Research
- Protein Structure and Dynamics
- Phytoestrogen effects and research
- Craniofacial Disorders and Treatments
- Bacterial Genetics and Biotechnology
- Immune Cell Function and Interaction
- Cellular transport and secretion
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Biotin and Related Studies
- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Multiple and Secondary Primary Cancers
- Autoimmune Neurological Disorders and Treatments
- Pain Mechanisms and Treatments
- Bacillus and Francisella bacterial research
- Cancer Immunotherapy and Biomarkers
- Fungal Infections and Studies
- Estrogen and related hormone effects
- Heat shock proteins research
National University of the Northeast
2014-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2023
University Hospital of Basel
2015-2019
University of Basel
2015-2019
Kantonsspital Graubünden
2019
Kantonsspital St. Gallen
2019
Institution Genevoise de Maintien à Domicile
2019
Hôpital du Valais
2019
Krebsliga Beider Basel
2019
University Hospital of Geneva
2015
The goal of this prospective randomized clinical trial was to compare 2 cohorts standardized cleft patients with regard functional speech outcome and the presence or absence palatal fistulae. are undergo either a conventional von Langenbeck repair intravelar velarplasty double-opposing Z-plasty Furlow procedure. A × factorial used in which each subject randomly assigned 1 8 different groups: lip repairs (Spina vs. Millard), (von Furlow), ages at time surgery (9-12 months 15-18 months). All...
Glyceollins, a group of novel phytoalexins isolated from activated soy, have recently been demonstrated to be antiestrogens that bind the estrogen receptor (ER) and inhibit estrogen-induced tumor progression. Our previous publications focused specifically on inhibition formation growth by glyceollin mixture, which contains three isomers (I, II, III). Here, we show mixture is also effective as potential antiestrogenic, therapeutic agent prevents estrogen-stimulated tumorigenesis displays...
Significance The immune system normally produces antibodies against pathogens and avoids making self-proteins. In some individuals, self-proteins (autoantibodies) are made can cause debilitating disease, but the reasons for this failure of self-tolerance not known. experiments described test following hypothesis linking viral infections production autoantibodies: A B cell whose immunoglobulin receptor recognizes a self-membrane protein capture that from membrane virus-infected simultaneously...
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during third and fourth waves in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 EW31/2022. Sequencing, phylogenetic phylodynamic analyses were performed. A differential dynamic found. wave associated with lineage BA.1, characterized a high number cases, very fast displacement Delta, doubling times 3.3 days low level...
Objective Cleft palate increases the risk of chronic middle ear disease and hearing loss. The goal this report was to determine which two surgeries timing surgery were associated with better otologic audiologic outcomes in children unilateral cleft lip at 5 6 years age. Design Subjects randomly assigned von Langenbeck intravelar veloplasty or Furlow repair, 9 12 months 15 18 age, Spina Millard repair. Setting Centralized, tertiary care craniofacial treatment center. Patients A total 673...
Ribonucleoparticle-independent transport of precursor proteins into mammalian microsomes is stimulated by 70-kDa heat shock (Hsc70) and an additional cytosolic protein. Here we addressed the question whether other molecular chaperones can replace Hsc70 in facilitating protein endoplasmic reticulum. Specifically, asked if members same family stress proteins, i.e. microsomal immunoglobulin heavy chain binding or bacterial DnaK, substitute for Hsc70. Furthermore, investigated with a proven role...
Objective: To study the growth of children with complete unilateral cleft lip and palate (UCLP) from birth to 2 years age construct specific UCLP curves. Design: Physical was a secondary outcome measure National Institutes Health–sponsored longitudinal, prospective clinical trial involving University Florida (United States) São Paulo (Brazil). Patients: Six hundred twenty-seven UCLP, nonsyndromic, both genders. Methods: Length, weight, head circumference were prospectively measured for group...
Determining antigen specificity is vital for understanding B cell biology and producing human monoclonal antibodies. We describe here a powerful method identifying cells that recognize membrane antigens expressed on cells. The technique depends two characteristics of the interaction between an antigen-expressing cell: antigen-receptor-mediated extraction from target cell, activation. developed using influenza hemagglutinin as model viral antigen, tested it acetylcholine receptor (AChR)...
To monitor the systemic immune responses of patients with multiple sclerosis (MS) under treatment GNbAC1, a monoclonal antibody against envelope protein MS- associated retrovirus, during phase 2a trial.We analyzed composition cell subsets and activation level monocytes by flow cytometry response viral vaccine antigens ELISpot.None endpoints measured revealed any immunosuppressive effect therapeutic antibody. Activation slightly decreased as predicted hypothesized mechanism action...
The presecretory protein ppcecDHFR, a hybrid between preprocecropinA and dihydrofolate reductase, is transported into mammalian microsomes post‐translationally, i.e. independent of ribosome signal recognition particle. Here, the involvement microsomal proteins in ribonucleoparticle‐independent transport ppcecDHFR was analyzed by trypsin‐pretreated truncated version subsequent chemical cross‐linking. We observed that post‐translational can occur which had been pretreated with trypsin (final...
The second wave of COVID-19 occurred in South America early 2021 and was mainly driven by Gamma Lambda variants. In this study, we aimed to describe the emergence local genomic diversity SARS-CoV-2 variant Argentina, from its initial entry into country until detection ceased. Molecular surveillance conducted on 9356 samples Argentina between October 2020 April 2022, sequencing, phylogenetic, phylogeographic analyses were performed. Our findings revealed that first detected January steadily...
Transport of bovine preprolactin into dog pancreas microsomes involves a microsomal protein which is sensitive to photoaffinity labeling with azido‐ATP and distinct from the ATP‐binding protein, immunoglobulin heavy chain binding protein. Here we addressed question what stage transport affected. Thus nascent presecretory related preprolactin, termed ppl‐86mer, was employed. show that did not become associated α‐subunit signal sequence receptor complex after azido‐ATP. Therefore, conclude...
Objetivo: Evaluar la efectividad del plasma rico en plaquetas (PRP) como adhesivo tisular autólogo para fijación autoinjerto conjuntival comparado con sutura de nylon 10-0 cirugía pterigión. Material y método: Se realizó un estudio prospectivo comparativo al estudiar a 64 pacientes pterigión primario. conformaron dos grupos: uno (grupo A) 33 operados PRP autólogo. Otro B) 31 10-0. analizaron hiperemia engrosamiento, compromiso limbar, invasión corneal, impresión clínica, signos, tiempo...
The presecretory protein ppcecDHFR, a hybrid between preprocecropin A and dihydrofolate reductase, is transported into mammalian microsomes post‐translationally, i.e. independently of ribosome signal recognition particle. Upon staging the transport process, stably folded ppcecDHFR bound to subsequently translocated across membrane. Membrane association depended on peptide but involved neither ATP nor an N ‐ethylmaleimide‐sensitive microsomal protein. insertion did not necessitate unfolding...
OBJECTIVE To test the hypothesis that viral infections can provoke autoimmunity via aberrant antigen capture and presentation by B cells. BACKGROUND The success of cell depleting therapies implicates cells in multiple sclerosis etiology, epidemiological evidence suggests CNS are a risk factor for disease. We hypothesize during infection, recognizing antigens on surface infected both self antigens, thereafter activate anti-viral autoreactive T co-capture viral-specific has not been widely...
e12090 Background: Chemokines have a fundamental role in inflammation and cancer progression. Chemokine receptor 4 (CXCR4) is transmembrane that belongs to the CXC chemokine family only known for Stromal Cell derived Factor-1(SDF-1). Many retrospective studies documented expression of various receptors, particularly CXCR4, was associated with poor prognosis patients breast cancer. In present study, we proposed an SDF-1/CXCR4 induced HER2/neu positive biopsies. We, additionally, study its...