Laura Formichelli
A5053574148- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- SARS-CoV-2 detection and testing
- Fungal Infections and Studies
- Vector-borne infectious diseases
- Plant Disease Resistance and Genetics
- Synthesis and Biological Evaluation
- Plant Pathogens and Fungal Diseases
- Insect symbiosis and bacterial influences
- Plant Virus Research Studies
National University of the Northeast
2012-2024
SUMMARY Genetic diversity of Trypanosoma cruzi may play a role in pathogenesis Chagas disease forms. Natural populations are classified into 6 Discrete Typing Units (DTUs) Tc I-VI with taxonomical status. This study aimed to identify T. DTUs bloodstream and tissue samples Argentinean patients disease. PCR-based strategies allowed DTU identification 256 clinical from 239 patients. V prevailed blood both asymptomatic symptomatic cases I was more frequent bloodstream, cardiac tissues chagoma...
SARS-CoV-2 variants with concerning characteristics have emerged since the end of 2020. Surveillance was performed on a total 4,851 samples from capital city and 10 provinces Argentina, during 51 epidemiological weeks (EWs) that covered first wave ongoing second COVID-19 pandemic in country (EW 44/2020 to EW 41/2021). The surveillance strategy mainly based Sanger sequencing Spike coding region allows identification signature mutations associated variants. In addition, whole-genome sequences...
The second wave of COVID-19 occurred in South America early 2021 and was mainly driven by Gamma Lambda variants. In this study, we aimed to describe the emergence local genomic diversity SARS-CoV-2 variant Argentina, from its initial entry into country until detection ceased. Molecular surveillance conducted on 9356 samples Argentina between October 2020 April 2022, sequencing, phylogenetic, phylogeographic analyses were performed. Our findings revealed that first detected January steadily...
Paracoccidioidomycosis is a severe systemic endemic mycosis caused by Paracoccidioides spp. which mainly affects individuals in Latin America. Progress genomics has been slow, as evidenced the incomplete reference databases available. Next-generation sequencing valuable tool for epidemiological surveillance and genomic characterization. With ability to sequence long reads without need prior amplification, Oxford Nanopore Technology (ONT) offers several advantages, but high-quality...