A5101945150- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Cardiac Ischemia and Reperfusion
- RNA Interference and Gene Delivery
- Genetics and Neurodevelopmental Disorders
- Antioxidants, Aging, Portulaca oleracea
- Anesthesia and Neurotoxicity Research
- Aluminum toxicity and tolerance in plants and animals
- Tryptophan and brain disorders
- Medicinal Plant Extracts Effects
- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Spinal Cord Injury Research
- Heat shock proteins research
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- ATP Synthase and ATPases Research
Chungnam National University
2021-2024
Seoul National University
2014-2023
Konkuk University Medical Center
2021
Hallym University Medical Center
2021
New Generation University College
2021
Hallym University
2021
Gangneung–Wonju National University
2021
National University College
2021
Dongguk University
2018
Seoul Institute
2018
Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated effects wild Indian Curcuma longa using Morris water maze paradigm on learning spatial memory in adult D-galactose-induced aged mice. addition, cell proliferation neuroblast differentiation were assessed by immunohistochemistry for Ki67 doublecortin (DCX) respectively. The aging model mice was induced through subcutaneous administration D-galactose (100 mg/kg) 10 weeks....
In the present study, we investigated effects of type 2 diabetes-induced hyperglycemia on integrity blood–brain barrier and tight junction markers in rat hippocampus. Forty-week-old diabetic (Zucker fatty, ZDF) rats littermate control lean control, ZLC) were used this study. We evaluated by measuring sodium fluorescein extravasation blood vessel ultrastructure. addition, markers, such as zona occludens-1, occludin claudin-5, quantified western blot analysis. ZDF showed significantly...
MOK, a pharmacopuncture medicine consisting of 10 herbs, has long history as treatment for various inflammatory conditions. To investigate the mechanisms action its anti‑inflammatory and antioxidative effects were assessed in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS). cells treated with different concentrations MOK extract 30 min prior to stimulation or without LPS indicated times. Nitric oxide (NO) production was measured using Griess reagent, while mRNA levels cytokines,...
Objectives: Luteolin, a common flavonoid from many plants, has various pharmacological activities, including memory-improving effect. In this study, we investigated the effects of luteolin on spatial memory, cell proliferation, and neuroblast differentiation in hippocampal dentate gyrus rat model scopolamine (SCO)-induced amnesia.Methods: Scopolamine was subcutaneously administered for 28 days via an Alzet minipump (44 mg/ml delivered at 2·5 μl/h) along with daily intraperitoneal...
Dendropanax morbifera Léveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated antioxidant effects a leaf extract in hippocampus mercury-exposed rats. Seven-week-old Sprague–Dawley rats received daily intraperitoneal injection 5 μg/kg dimethylmercury and/or oral (100 mg/kg) 4 weeks. Animals were sacrificed 2 h after last treatment. Mercury levels measured homogenates hippocampal tissue, brain region that is vulnerable to mercury...
Dendropanax morbifera Léveille is used in herbal medicine as a cancer treatment. In this study, we investigated the effects of stem extract (DMS) on cadmium (Cd) excretion from blood and kidney brain tissues rats exposed to cadmium, well DMS oxidative stress antioxidant levels hippocampus after Cd exposure. Seven-week-old Sprague-Dawley were 2 mg/kg by intragastric gavage orally administered 100 for 4 weeks. Animals sacrificed determination was performed using inductively coupled plasma mass...
Abstract Introduction The aim of this study was to investigate the effects cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects neuronal degeneration induced by cuprizone. Methods Eight‐week‐old male C57BL/6J mice were randomly divided into three groups: (a) control group, (b) group treated with only, and (c) both melatonin. Cuprizone administered food at 0.2% ad libitum for 6 weeks. Melatonin tap water g/L weeks; animals then...
Objectives:Histone deacetylases (HDACs) play a key role in synaptic plasticity and learning memory. Sirtuin 2 (SIRT2), class III HDAC, is abundantly expressed neurons functions as mitotic exit regulator dividing cells. In this study, we investigated the of SIRT2 cell proliferation neuroblast differentiation mouse dentate gyrus.Methods:To facilitate delivery into neurons, constructed PEP-1-SIRT2 fusion protein. Mice were divided three groups: vehicle (PEP-1), SIRT2, with sodium butyrate (an...
Cryptorchidism is one of the most common genital defects in dogs. This study investigated effects abdominal cryptorchidism on morphology, cell proliferation, and Sertoli condition a dog with spontaneous unilateral cryptorchidism. Elective orchidectomy was performed right testis scrotal left testis. Significant reductions numbers spermatogonia, spermatocytes, spermatids were observed hematoxylin eosin stained sections cryptorchid The size epididymal duct smaller than that control Based Ki67...
Cadmium leads to learning and memory impairment. Dendropanax morbifera Léveille stem extract (DMS) reduces cadmium-induced oxidative stress in the hippocampus. We investigated effects of DMS on impairments rats.Cadmium (2 mg/kg), with or without (100 was orally administered 7-week-old Sprague-Dawley rats for 28 days. Galantamine (5 an acetylcholinesterase inhibitor, intraperitoneally as a positive control. A novel-object recognition test conducted 2 h after final administration. Cell...
Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione family, plays role cellular detoxification against oxidative stress. Although stress is related to ischemic injury, GSTA2 ischemia has not been elucidated. Thus, we studied whether prevents injury by using PEP-1-GSTA2 protein which cell-permeable transduction domain. We revealed that transduced into HT-22 cells and markedly protected cell death via inhibition reactive oxygen species (ROS) production DNA damage induced...
Abstract In the present study, we searched for possible candidates that can prevent ischemic damage in rabbit spinal cord. For this used two-dimensional gel electrophoresis followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, sham- and ischemia-operated animals. As level of protein disulfide-isomerase A3 (PDIA3) significantly decreased 3 h after ischemia/reperfusion, further investigated its role against using an vitro cord cell line vivo model. The...
Aging negatively affects adult hippocampal neurogenesis, and exercise attenuates the age-related reduction in neurogenesis. In present study, we used senescent mice induced by D-galactose to examine neural stem cells, cell proliferation, neuronal differentiation with or without treatment. (100 mg/kg) was injected six-week-old C57BL/6 J for 6 weeks induce model. During these periods, animals were placed on a treadmill acclimated 1 week. Then running conducted h/day 5 consecutive days at 10-12...
The present study investigated the effects of hypothyroidism on cyclooxygenase-2 (COX-2) and pro‑inflammatory cytokines in dentate gyrus to elucidate roles COX‑2 hypothyroid hippocampus. Hypothyroidism was induced rats by treating with 0.03% 2‑mercapto‑1‑methyl‑imidazole dissolved drinking water for 5 weeks. animals were sacrificed at 12 weeks age. exhibited decreased triiodothyronine thyroxine levels serum, while thyroid‑stimulating hormone weight thyroid glands significantly higher...
Abstract Purpurin has various effects, including anti-inflammatory and can efficiently cross the blood–brain barrier. In present study, we investigated effects of purpurin on oxidative stress in HT22 cells mild brain damage gerbil hippocampal CA1 region induced by transient forebrain ischemia. Oxidative H 2 O was significantly ameliorated treatment with purpurin, based changes cell death, DNA fragmentation, formation reactive oxygen species, pro-apoptotic (Bax)/anti-apoptotic (Bcl-2) protein...
As a medicinal plant, the roots of Valeriana officinalis have been used as sedative and tranquilizer. In present study, we evaluated neuroprotective effects valerian root extracts (VE) on hippocampal CA1 region gerbils after 5 min transient cerebral ischemia. Gerbils were administered VE orally once day for 3 weeks, subjected to ischemia/reperfusion injury, continued weeks. The administration 100 mg/kg (VE100 group) significantly reduced ischemia-induced spontaneous motor hyperactivity 1...
The genetic background of mice has various influences on the efficacy physical exercise, as well adult neurogenesis in hippocampus. In this study, we investigated basal level hippocampal neurogenesis, effects treadmill exercise 9 mouse strains: 8 very commonly used laboratory inbred strains (C57BL/6, BALB/c, A/J, C3H/HeJ, DBA/1, DBA/2, 129/SvJ, and FVB) 1 outbred strain (ICR). All showed diverse levels cell proliferation, neuroblast differentiation, integration into granule cells sedentary...
In a previous study, we demonstrated that Valeriana officinalis extract could attenuate increases in serum corticosterone levels mouse model of physical and psychological stress. addition, our results showed the modulate serotonin (5-HT) norepinephrine (NE) turnover hippocampus amygdala region. this intended to investigate effects valerenic acid (VA), main component V. extract, on normal mice monoamine hippocampus-amygdala homogenates To determine minimum dose VA for antianxiety effect,...
Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high healthy animals, the function this factor adult neurogenesis not been clearly demonstrated. Therefore, we performed present study to compare effects pharmacological genetic inhibition on hippocampal neurogenesis. Physiological saline or same volume containing celecoxib was administered perorally every day for 5 weeks using a...