A5100712100- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Digital Filter Design and Implementation
- Advanced Adaptive Filtering Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Numerical Methods and Algorithms
- interferon and immune responses
- MRI in cancer diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
- Pancreatic function and diabetes
- Neurosurgical Procedures and Complications
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Wenzhou Medical University
2020-2025
University of Minnesota
2003-2024
China Medical University
2024
Anqing City Hospital
2021-2024
China Pharmaceutical University
2024
Capital Medical University
2013-2023
Beijing Tian Tan Hospital
2013-2023
Beijing Obstetrics and Gynecology Hospital
2023
Jinling Institute of Technology
2023
Objective: To compare short-term surgical outcomes and quality of life (QOL) between single-port laparoscopic cholecystectomy (SPLC) classic 4-port (CLC). Background: There is significant interest in further reducing the trauma associated with procedures. Although a number observational studies have suggested that SPLC feasible alternative to CLC, there lack data from randomized validating any benefit over CLC. Methods: Eligible patients were receive or Operative perioperative outcomes,...
Patients afflicted with low-grade glioma (LGG) frequently suffer from seizures. The mechanisms of seizure initiation in these patients remain poorly understood. Tumor location has been correlated initiation. However, correlative studies relied on dichotomized data analysis based arbitrary lobe assignments. As a result, the lesion-symptom correlation may be incorrectly interpreted. Here, we present first study that used voxel-wise quantitative lesion to investigate spatial between tumor and...
Methamphetamine (METH) is a psychostimulant with high abuse potential and severe neurotoxicity. Recent studies in animal models have indicated that METH can impair the blood–brain barrier (BBB), suggesting some of neurotoxic effects resulting from could be due to disruption. We report here while chronic exposure disrupts function primary human brain microvascular endothelial cells (HBMECs) umbilical vein (HUVECs), an early pro-survival response observed following acute by induction...
Abstract The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with to detect somatic mutations then validate the digital polymerase chain reaction (PCR) analysis tissue samples from 227 prolactinomas. We identify same hotspot mutation in splicing factor 3 subunit B1 ( SF3B1 R625H ) 19.8% These mutant display higher prolactin (PRL) levels p = 0.02) shorter progression-free survival (PFS)...
BackgroundRecurrence after radiation therapy is nearly universal for glioblastomas, the most common form of adult brain cancer. The study aims to define clinically pertinent mechanisms underlying this recurrence.MethodsmicroRNA (miRNA) profiling was performed using matched pre- and post-radiation treatment glioblastoma specimens from same patients. All harbored unmethylated O6-methylguanine-DNA methyltransferase promoters (umMGMT) wild-type isocitrate dehydrogenase (wtIDH). altered miRNA,...
Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding the molecular features that define this response, we applied integrated, multiplatform analysis RNA profiles derived from clinically annotated glioblastoma samples. This suggested specimens responders are characterized by decreased accumulation microglia/macrophages microenvironment. Glioblastoma-associated secreted interleukin 11 (IL11) to activate STAT3-MYC signaling cells....
The ABC/2 method is usually applied to evaluate intracerebral hemorrhage (ICH) volume on computed tomography (CT), although it might be inaccurate and not applicable in estimating extradural or subdural (EDH, SDH) due their irregular hematoma shapes. This study aimed deep framework optimized for the segmentation quantification of ICH, EDH, SDH.The training datasets were 3,000 images retrospectively collected from a collaborating hospital (Hospital A) segmented by Dense U-Net framework. Three...
Diabetes and diabetic nephropathy are complex diseases affected by genetic environmental factors. Identification of the susceptibility genes investigation their roles may provide useful information for better understanding pathogenesis developing novel therapeutic approaches. Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein expressed on endothelial cells leukocytes in immune system. The ICAM1 gene located chromosome 19p13 within linkage region diabetes. In recent...
Background and purpose A brain tumor's location is associated with the genetic profile of its tumor precursor cells. Mutations in isocitrate dehydrogenase 1 ( IDH 1) are an early event development play a critical role gliomagenesis. This study was conducted to specify anatomical characteristics mutation low‐grade gliomas further explore origin mutation. The impact on disease prognosis also evaluated. Methods pre‐operative magnetic resonance images obtained from 146 patients histologically...
MOK, a pharmacopuncture medicine consisting of 10 herbs, has long history as treatment for various inflammatory conditions. To investigate the mechanisms action its anti‑inflammatory and antioxidative effects were assessed in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS). cells treated with different concentrations MOK extract 30 min prior to stimulation or without LPS indicated times. Nitric oxide (NO) production was measured using Griess reagent, while mRNA levels cytokines,...
Abstract Background Delirium was characterized with a series of symptoms sudden onset disturbances in attention, loss memory and defects other cognitive abilities that were also appeared the syndrome anxiety. Even though there are overlapped clinical existed anxiety delirium, relationship between delirium still unclear. The propose this study to investigated effect preoperative on postoperative delirium. Methods Three hundred seventy-two adults undergoing total hip arthroplasty enrolled from...
Abstract Guanylate binding proteins (GBPs), a family of interferon-inducible large GTPase, play pivotal role in cell-autonomous immunity and tumor malignant transformation. Glioblastoma (GBM) is the most prevalent lethal primary brain adults. Here we show that GBP5 was highly expressed GBM cell lines clinical samples, especially mesenchymal subtype. The expression levels were negatively correlated with prognosis patients. Overexpression promoted proliferation, migration, invasion cells vitro...
<h3>BACKGROUND AND PURPOSE:</h3> It is proposed that <i>isocitrate dehydrogenase 1</i> (<i>IDH1</i>) mutation predicts the outcome in patients with high-grade glioma. In addition, contrast enhancement on preoperative MR imaging reflects tumor biologic features. Patients anaplastic glioma <i>IDH1</i> were evaluated by using to determine whether a prognostic factor and can be used predict survival. <h3>MATERIALS METHODS:</h3> A cohort of 216 histologically confirmed was reviewed...
Multiple-attribute group decision making (MAGDM) under linguistic environment is an important part of modern sciences, and information aggregation operator plays import role in solving MAGDM problems. In this paper, approach for problem with q-rung orthopair fuzzy 2-tuple developed. First, the weighted averaging (q-ROFTLWA) geometric (q-ROFTLWG) are presented. Furthermore, Muirhead mean (q-ROFTLMM) dual (q-ROFTLDMM) proposed on basis (MM) (DMM) operator. Then, developed to deal based...
Gayal and yak are well adapted to their local high-altitude environments, yet the transcriptional regulation difference of plateau environment among them remains obscure. Herein, cross-tissue cross-species comparative transcriptome analyses were performed for six hypoxia-sensitive tissues from gayal, yak, cattle. Gene expression profiles all single-copy orthologous genes showed tissue-specific patterns. By differential analysis, we identified 3,020 1,995 differentially expressed (DEGs) in at...
Abstract Objective Rapid on-site evaluation (ROSE) of respiratory cytology specimens is a critical technique for accurate and timely diagnosis lung cancer. However, in China, limited familiarity with the Diff-Quik staining method shortage trained cytopathologists hamper utilization ROSE. Therefore, developing an improved deep learning model to assist clinicians promptly accurately evaluating stained samples during ROSE has important clinical value. Methods Retrospectively, 116 digital images...