A5080127932- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- HIV Research and Treatment
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Natural Compounds in Disease Treatment
- Ginseng Biological Effects and Applications
- Dermatology and Skin Diseases
- Immune cells in cancer
- Signaling Pathways in Disease
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- Ocular Diseases and Behçet’s Syndrome
- Cannabis and Cannabinoid Research
- Adenosine and Purinergic Signaling
Hallym University
2015-2025
Daewon University College
2020
Chuncheon Sacred Heart Hospital
2020
Hallym University Medical Center
2012-2020
Targeting the gut-liver axis by modulating gut-microbiome can be a promising therapeutic approach in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate effects single species and combination Lactobacillus Pediococcus NAFLD mice model. Six-week male C57BL/6J were divided into 9 groups (n = 10/group; normal, Western diet, 7 diet-strains [109 CFU/g, 8 weeks]). strains used L. bulgaricus, casei, helveticus, P. pentosaceus KID7, three combinations (1: casei+L. 2:...
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There a paucity of research on which strains gut microbiota affect the progression NAFLD. This study explored NAFLD-associated microbiome in humans and role <i>Lactobacillus</i> NAFLD mice.Methods: The was analyzed via next-generation sequencing healthy people (n=37) patients with elevated enzymes (n=57). Six-week-old male C57BL/6J mice were separated into six groups (n=10 per group;...
We isolated the phenolic glucoside salicortin from a Populus euramericana bark extract, and examined its ability to suppress inflammatory responses as well molecular mechanisms underlying these abilities, using lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Salicortin inhibited iNOS expression subsequent production of NO in dose-dependent manner LPS-stimulated RAW 264.7 significantly suppressed LPS-induced signal cascades NF-<TEX>${\kappa}B$</TEX> activation, such IKK...
Abstract Objectives Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and murine model arthritis as treatment option for rheumatoid (RA). Methods was overexpressed mouse peritoneal macrophages RAW 264.7 cells, inhibitor CKD-506 on cytokine production activity NF-κB AP-1 signaling were examined. Peripheral blood mononuclear cells (PBMCs) from RA patients fibroblast-like synoviocytes (FLS) activated...
Human immunodeficiency virus (HIV)-1 transactivator of transcription (Tat) is a viral protein that induces extensive neuroinflammation by up-regulating proinflammatory mediators, including cytokines, chemokines, and adhesion molecules. Histone deacetylase 6 (HDAC6) has been implicated in the transcriptional regulation inflammatory genes. In this study, we investigated possible role HDAC6 HIV-1 Tat-induced up-regulation mediators astrocytes. Tat augmented expression, which was correlated with...
Upregulation of pro-inflammatory mediators contributes to <TEX>${\beta}$</TEX>-cell destruction and enhanced infiltration immune cells into pancreatic islets during development type 1 diabetes mellitus. In this study, we examined the regulatory effects mechanisms action celastrol against cytotoxicity responses in RINm5F rat line stimulated with a combination interleukin-1 beta, tumor necrosis factor-alpha, interferon-<TEX>${\gamma}$</TEX>. Celastrol significantly restored cytokine-induced...
Histone deacetylase 6 (HDAC6) likely is important in inflammatory diseases. However, how HDAC6 exerts its effect on processes remains unclear. HIV-1 transactivator of transcription (Tat) activates NADPH oxidase resulting generation reactive oxygen species (ROS), leading to extensive neuro-inflammation the central nervous system. We investigated correlation and Tat-stimulated astrocytes. knockdown attenuated Tat-induced ROS activation. suppressed expression subunits, such as Nox2, p47phox,...
Hepatocellular carcinoma (HCC), one of the leading causes death worldwide, has a causal nexus with liver injury, inflammation, and regeneration that accumulate over decades. Observations from recent studies have accounted for involvement gut-liver axis in pathophysiological mechanism responsible HCC. The human intestine nurtures diversified colony microorganisms residing host ecosystem. intestinal barrier is critical conserving normal physiology gut microbiome. Therefore, rupture this or...
Adhesion molecules such as ICAM-1 are important in the infiltration of leukocytes into site inflammation.In this study, we investigated inhibitory effects curcumin on expression and monocyte adhesiveness well its underlying action mechanism TNF-α-stimulated keratinocytes.Curcumin induced heme oxygenase-1 (HO-1) human keratinocyte cell line HaCaT.In addition, Nrf2 activation dose-and time-dependent manners HaCaT cells.Curcumin suppressed TNF-αinduced subsequent adhesion, which were reversed...
Up-regulation of cell adhesion molecules and proinflammatory cytokines contributes to enhanced monocyte adhesiveness infiltration into the skin, during pathogenesis various inflammatory skin diseases, including atopic dermatitis. In this study, we examined anti-inflammatory effects butein, a tetrahydroxychalcone, its action mechanisms using TNF-α-stimulated keratinocytes. Butein significantly inhibited TNF-α-induced ICAM-I expression in human keratinocyte line HaCaT. also decreased...
Korea Red Ginseng (KRG) has been used as remedies with hepato-protective effects in liver-related condition. Microbiota related gut-liver axis plays key roles the pathogenesis of chronic liver disease. We evaluated effect KRG on patients nonalcoholic statohepatitis by modulation gut-microbiota.A total 94 (KRG: 45 and placebo: 49) were prospectively randomized to receive (2,000 mg/day, ginsenoside Rg1+Rb1+Rg3 4.5mg/g) or placebo during 30 days. Liver function test, cytokeraton 18, fatigue...
Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione family, plays role cellular detoxification against oxidative stress. Although stress is related to ischemic injury, GSTA2 ischemia has not been elucidated. Thus, we studied whether prevents injury by using PEP-1-GSTA2 protein which cell-permeable transduction domain. We revealed that transduced into HT-22 cells and markedly protected cell death via inhibition reactive oxygen species (ROS) production DNA damage induced...
In the central nervous system, viral infection can induce inflammation by up-regulating pro-inflammatory mediators that contribute to enhanced infiltration of immune cells into areas. Celastrol is known exert various regulatory functions, including anti-microbial activities. this study, we investigated effects and mechanisms action celastrol against astrocytes activated with polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, as model mediated responses. significantly inhibited...
Up-regulation of adhesion molecules plays an important role in the infiltration leukocytes into skin during development various inflammatory diseases, such as atopic dermatitis. In this study, we investigated modulatory effects 2,3-dimethoxy-2′-hydroxychalcone (DMHC) on tumor necrosis factor (TNF)-α-induced intercellular molecule-1 (ICAM-1) expression and monocyte adhesiveness, well molecular mechanisms underlying its action HaCaT human keratinocyte cell line. Pre-treating cells with DMHC...
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