A5078813466- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Psoriasis: Treatment and Pathogenesis
- Otitis Media and Relapsing Polychondritis
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Muscle and Compartmental Disorders
- Bone and Joint Diseases
- Histone Deacetylase Inhibitors Research
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
Seoul National University
2016-2025
National University College
2013-2025
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2025
National Institutes of Health
2007-2025
Seoul National University Hospital
2015-2024
Center for Rheumatology
2015-2024
Kyungpook National University
2017-2023
New Generation University College
2006-2022
Hanyang University Seoul Hospital
2022
Soonchunhyang University
2020
To determine whether a 2-week methotrexate (MTX) discontinuation after vaccination improves the efficacy of seasonal influenza in patients with rheumatoid arthritis (RA).In this prospective randomised parallel-group multicentre study, RA on stable dose MTX were randomly assigned at ratio 1:1 to continue or hold for 2 weeks 2016-2017 quadrivalent vaccine containing H1N1, H3N2, B-Yamagata and B-Victoria. The primary outcome was frequency satisfactory response, defined as greater than equal...
To investigate whether temporary discontinuation of methotrexate (MTX) improves the efficacy seasonal influenza vaccination in patients with rheumatoid arthritis (RA).In this prospective randomised parallel-group trial, RA taking stable dose MTX were randomly assigned at a ratio 1:1:1:1 to continue (group 1), suspend for 4 weeks before 2), 2 and after 3) or 4). All participants vaccinated trivalent vaccine containing H1N1, H3N2 B-Yamagata. The primary outcome was frequency satisfactory...
Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute the inflammatory response systemic lupus erythematosus (SLE).Exosomes were purified from SLE patients and healthy controls (HCs). Healthy peripheral blood mononuclear cells (PBMCs) stimulated with isolated HCs presence or absence Toll-like receptor (TLR) inhibitors. Production interferon (IFN)-α, tumor necrosis factor (TNF)-α, interleukin (IL)-1β,...
Abstract Introduction The aim of this study was to explore the presence and localization myocardial citrullination in samples from rheumatoid arthritis (RA) patients compared rheumatic non-rheumatic disease control groups. Methods Archived obtained during autopsy 1995 2009 were assembled into four groups: RA; scleroderma; fatal myocarditis; controls. Samples examined by immunohistochemistry (IHC) for peptidyl arginine deiminase enzymes (PADs) a single cardiovascular pathologist blinded group...
Recent studies have suggested that neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein-to-albumin (CAR) are emerging markers of disease activity prognosis in patients with chronic inflammatory diseases, cardiovascular or malignancies. Therefore, we investigated the clinical significance prognostic value NLR CAR adult polymyositis dermatomyositis. The medical records 197 newly diagnosed polymyositis/dermatomyositis between August 2003 November 2016 were retrospectively reviewed....
Citrullination, the post-translational conversion of arginine to citrulline by enzyme family peptidylarginine deiminases (PADs), is associated with several diseases, and specific citrullinated proteins have been shown alter function while others act as auto-antigens. In this study, we identified in human myocardial samples, from healthy heart failure patients, determined potential functional consequences. Further investigated PAD isoform cell-specific expression heart. A...
Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the of new selective HDAC6 inhibitor, CKD-L, compared ITF 2357 or Tubastatin A on CIA and regulatory T (Treg) cells patients with rheumatoid (RA). was induced by bovine type II collagen (CII) DBA/1 J mice. Mice were treated HDAC for 18 days. Arthritis score assessed histological analysis performed hematoxylin eosin...
Bruton's tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects HM71224, a novel Btk inhibitor, both in vitro mouse model experimental arthritis. The inhibition profile HM71224 was analyzed. on monocytes were analyzed by examining phosphorylation its downstream signaling molecules, along with cytokine production osteoclast formation. vivo investigated collagen-induced arthritis (CIA). irreversibly bound inhibited (IC50 =...
Abstract The objective of the study was to identify distinct patterns in inflammatory immune responses COVID-19 patients and investigate their association with clinical course outcome. Data from hospitalized were retrieved electronic medical record. Supervised k-means clustering serial C-reactive protein levels (CRP), absolute neutrophil counts (ANC), lymphocyte (ALC) used assign one three groups. Then, relationships between outcome assessed a discovery validation cohort. Unbiased analysis...
With improved understanding of disease pathogenesis and availability outcome measures, there has been a remarkable increase in the number therapeutic clinical trials idiopathic inflammatory myopathies (myositis) over last three years reaching as many five per site. These share similar design inclusion/exclusion criteria resulting competitive trial landscape myositis. While these are exciting times for myositis field, we have concerns about conduct trials. include landscape, lengthy placebo...
In order to identify putative biomarkers in lipoprotein, we compared lipid and lipoprotein properties between rheumatoid arthritis (RA) patients control with similar age.We analyzed four classes of lipoproteins (VLDL, LDL, HDL2, HDL3) from both male (n = 8, 69±4 year-old) female 25, 53±7 as well controls age 13).Although RA group showed normal levels total cholesterol (TC), low-density (LDL)-cholesterol, glucose, however, the significantly reduced high-density (HDL)-C level ratio HDL-C/TC....
To investigate the impact of tumor necrosis factor inhibitor (TNFi) treatment and inflammation control on radiographic progression in early ankylosing spondylitis (AS) over 4 years.We included a total 215 patients with AS (symptom duration <10 years) treated TNFi (the group; n = 135) or nonsteroidal antiinflammatory drugs (NSAIDs) 80). Two blinded readers assessed using modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Inflammation was inferred from C-reactive protein (CRP) levels...
Abstract Introduction Rheumatic diseases (RDs) are associated with different cancers; however, it is unclear whether particular cancers more prevalent in certain RDs. In the present study, we examined relative incidence of several a single homogeneous cohort patients Methods Patients ( N = 3,586) diagnosed rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), sclerosis (SSc), dermatomyositis (DM) or polymyositis were included. Cancer diagnosis was based on histopathology. The 2008...
Autoimmune manifestations (AIMs) are common in patients with myelodysplastic syndrome (MDS). This study aimed to investigate whether AIMs associated a specific cytogenetic abnormalities and worse survival MDS. A total of 67 MDS 134 age- sex-matched without AIMs, all whom received medical care at Seoul National University Hospital from January 2000 through July 2014, were enrolled. The clinical features, chromosomal abnormalities, outcomes examined. effect on mortality was estimated after...
Objective Immune cells from patients with rheumatoid arthritis (RA) express more enolase-1 (ENO1) on their surface than those healthy subjects, and they elicit an enhanced inflammatory response. This study is aimed to identify the ligands of ENO1 that could promote loops in vitro enhance severity vivo. Methods ENO1-binding proteins RA synovial fluid were identified by mass spectromety, affinity was evaluated means a ligand blotting binding assay, plasmon resonance confocal microscopy....
Abstract Objectives Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and murine model arthritis as treatment option for rheumatoid (RA). Methods was overexpressed mouse peritoneal macrophages RAW 264.7 cells, inhibitor CKD-506 on cytokine production activity NF-κB AP-1 signaling were examined. Peripheral blood mononuclear cells (PBMCs) from RA patients fibroblast-like synoviocytes (FLS) activated...
This study aimed to investigate the characteristics of exosomes isolated from synovial fluid and their role in osteoclast differentiation different types inflammatory arthritis. Exosomes rheumatoid arthritis (RA), ankylosing spondylitis (AS), gout, osteoarthritis (OA) patients were co-incubated with CD14+ mononuclear cells healthy donors without macrophage colony-stimulating factor (M-CSF) receptor activator nuclear kappa-B ligand (RANKL). Osteoclast was evaluated via tartrate-resistant acid...
Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis.
The study objective was to determine if a common single nucleotide polymorphism in the interleukin 6 (IL-6) receptor (rs2228145, p.Asp358Ala) predicted treatment response tocilizumab giant cell arteritis (GCA). Genetic sequencing of rs2228145 locus performed 2 independent cohorts patients with GCA. Peripheral blood mononuclear cells (PBMCs) from and controls were evaluated for expression (IL-6R) its coreceptor, gp130, using flow cytometry. same PBMCs stimulated IL-6 downstream targets IL-6:...
To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients poor prognosis.Seventy-seven RA ILD and 231 age, sex, duration-matched without were enrolled this retrospective study. Epidemiologic, clinical, laboratory information obtained through a medical chart review. Logistic regression analysis was used to estimate the risk mortality ILD.Compared group, group had significantly higher titers factor anti-cyclic...
To present and vote on a myositis modified patient-reported outcome core domain set in the life impact area at Outcome Measures Rheumatology (OMERACT) 2018.Based results from international focus groups Delphi surveys, draft was developed.Domains muscle symptoms, fatigue, level of physical activity, pain reached ≥ 70% consensus were mandatory to assess all trials. Domains lung, joint, skin symptoms specific circumstances. This endorsed by > 85% OMERACT 2018.We propose for patients with...
The purpose of this study is to describe MRI findings muscle involvement in patients with polyarteritis nodosa (PAN), an emphasis on the contrast enhancement characteristics.MRI studies eight PAN were retrospectively reviewed (four male and four female patients; mean age at presentation, 34.3 years; range, 7-64 years). MR images evaluated focusing following features: affected structures (muscle, fascia, or periosteum), lesion signal intensity characteristics T1-and T2-weighted images,...