A5103192452- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Oral Health Pathology and Treatment
- Oral microbiology and periodontitis research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Tissue Engineering and Regenerative Medicine
- Systemic Lupus Erythematosus Research
- Synthesis of β-Lactam Compounds
- MicroRNA in disease regulation
- Synthesis and Biological Evaluation
- Vasculitis and related conditions
- Hepatitis C virus research
- Ocular Diseases and Behçet’s Syndrome
- Electrospun Nanofibers in Biomedical Applications
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- Pluripotent Stem Cells Research
- Otitis Media and Relapsing Polychondritis
- Organic Chemistry Cycloaddition Reactions
XCell Science (United States)
2022
Seoul National University
2015-2020
Korea Research Institute of Chemical Technology
2020
Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute the inflammatory response systemic lupus erythematosus (SLE).Exosomes were purified from SLE patients and healthy controls (HCs). Healthy peripheral blood mononuclear cells (PBMCs) stimulated with isolated HCs presence or absence Toll-like receptor (TLR) inhibitors. Production interferon (IFN)-α, tumor necrosis factor (TNF)-α, interleukin (IL)-1β,...
Human mesenchymal stem cells (hMSCs)-derived extracellular vesicles (EVs) have been known to possess the features of origin cell with nano size and shown therapeutic potentials for regenerative medicine in recent studies as alternatives cell-based therapies. However, extremely low production yield, unknown effects derived from serum impurities, relatively bioactivities on doses must be overcome translational applications. As several reports demonstrated tunability secretion EVs, herein, we...
A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation rheumatoid arthritis (RA).Two hundred sixty-four RA patients 88 age- sex-matched controls underwent dental exam. Additionally, manifestations including disease activity anti-citrullinated protein antibodies were evaluated in patients.The prevalence moderate or severe higher compared (63.6% vs 34.1%, p < 0.001). In markers periodontal inflammation, bleeding on...
Stem cells are attractive candidates for the regeneration of tissue and organ. Mesenchymal stem (MSCs) have been extensively investigated their potential applications in regenerative medicine cell therapy. For developing effective therapy, mass production consistent quality is required. The culture medium most critical aspect qualified cells. Classically, fetal bovine serum (FBS) has used as a supplement MSCs. Due to undefined heterologous composition animal origin components FBS, efforts...
Periodontitis (PD) has been reported to be associated with rheumatoid arthritis (RA). Porphyromonas gingivalis (P. gingivalis) is a gram-negative anaerobic bacterium that recognized as one of the major pathogenic organisms in PD and only known express peptidylarginine deiminase (PAD). Antibody against human α-enolase (ENO1) autoantibodies RA. ENO1 highly conserved protein, could candidate molecule for molecular mimicry between bacterial proteins. In present study, we measured serum antibody...
Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis.Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), key factor in the development of RA.This study aimed at evaluating relationships between 2 diseases identifying clinical implications thereof, with focus on periodontal pathogens Korean adults.Methods: A total 260 RA patients 86 age-and sex-matched control without were enrolled this...
<h3>Background</h3> Prostaglandin E2 (PGE2) is one of the most abundant prostaglandins, with crucial roles in normal and pathologic physiology. Especially, PGE2 levels are abnormally elevated many cancers, high known to be pro-tumorigenic, likely due immune suppressive effect tumor microenvironment.<sup>1–4</sup> There four types receptors; EP1, EP2, EP3 EP4. Among them, EP2 EP4 activate adenylate cyclase increase cAMP levels, which induce cAMP-dependent protein kinase (PKA) signaling...
Abstract Stem cells are attractive candidates for the regeneration of tissue and organ. Mesenchymal stem (MSCs) have been extensively investigated their potential applications in regenerative medicine cell therapy. For developing effective therapy, mass production consistent quality is required. The culture medium most critical aspect qualified cells. Classically, fetal bovine serum (FBS) has used as a supplement MSCs. Due to undefined heterologous composition animal origin components FBS,...