RANKL is a tumor necrosis factor (TNF)-like secreted by mesenchymal cells, osteoblast derivatives, and T cells that essential for osteoclastogenesis. In osteoblasts, expression regulated two major calcemic hormones, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] parathyroid hormone (PTH), as well several inflammatory/osteoclastogenic cytokines; the molecular mechanisms this regulation are unclear. To identify such mechanisms, we screened DNA microarray which tiled across entire mouse RankL...

Abstract 1,25(OH)2D3 induces gene expression through the VDR. We used chromatin immunoprecipitation techniques to explore this 1,25(OH)2D3-induced process on 25-hydroxyvitamin D3-24-hydroxylase (Cyp24) and Opn promoters in intact osteoblasts. Our studies show that transactivation is a dynamic involves promoter-specific localization of VDR RXR, recruitment histone acetyltransferase complexes, case Cyp24 gene, modification 4. Introduction: The vitamin D receptor (VDR) binds as retinoid X (RXR)...

We report a nanosensor that uses cell lysates to rapidly profile the tumorigenicity of cancer cells. This sensing platform host–guest interactions between cucurbit[7]uril and cationic headgroup gold nanoparticle non-covalently modify binding three fluorescent proteins multi-channel sensor in situ. approach doubles number output channels six, providing single-well identification with 100% accuracy. Significantly, this classification could be extended beyond training set, determining...

Dental implants generally provide good results as replacements for missing teeth, but a few patients experience implant failure. The aim of this retrospective study was to analyze the characteristics and causes failures in hopes reducing future failures.Patients who received one or more at Hospital Yonsei University College Dentistry between February 1991 May 2009 were included study. Data including age, sex, medical history, habits (eg, smoking drinking), bone quality, primary stability,...

Purpose: Implant stability at the time of surgery is crucial for long-term success dental implants.Primary considered paramount importance to achieve osseointegration.The purpose present study was investigate correlation between insertion torque and primary implants using artificial bone blocks with different densities compositions mimic circumstances that are encountered in routine daily clinical settings.Methods: In order validate objectives, various sized holes were made (#10, #20, #30,...

Abstract Fungus ball is the most common form of non-invasive fungal sinusitis, and maxillary sinus commonly involved site. Maxillary fungus (MFB) accounts for a considerable proportion unilateral sinusitis. The prevalence MFB has recently increased; however, its contributing factors are unclear. This study analyzed association between dental implants. One hundred one patients who underwent surgery were divided into two groups based on surgical biopsy results: bacterial sinusitis (UBS, n =...

To investigate the change in 89 patients' pain and anxiety following implant surgery to evaluate correlation among anxiety, pain, influencing factors.Eighty-nine patients were included this study. Subjective factors perception from overall dental treatment (scored on Dental Anxiety Scale [DAS]) relative time surgery. Objective sex, age, location number. Patients completed questionnaires just before (T0), immediately after (T1), 1 day (T2), week (T3).The average was highest at T2, followed by...

Abstract Few trials have shown that promoting complementary feeding among young children is effective in improving child linear growth resource‐challenged settings. We designed a community‐based participatory nutrition promotion (CPNP) programme adapting Positive Deviance/Hearth approach engaged mothers 2‐week sessions using the principles of ‘learning by doing’ around feeding. aimed to test effectiveness CPNP for rural Ethiopia. A cluster randomized trial was implemented adding existing...

Gingival fibroblasts are a major cellular component of the connective tissue and play crucial role in wound healing regeneration through collagen synthesis. This study aimed to assess effect polynucleotide (PN) combined with cross-linked hyaluronic acid (HA) on proliferation, differentiation, anti-inflammatory responses human gingival fibroblasts-1 (HGF-1). In this vitro experimental study, HGF-1 cells were cultured PN/HA, PN, HA, enamel matrix derivative (EMD). Cell proliferation migration...

Abstract Traditionally, intrasocket granulation tissue (IGT) has been regarded as infected to be removed during extraction facilitate bone healing. However, recent findings suggest that IGT can support primary closure, preserving keratinized mucosa and enhancing healing potential without requiring additional soft grafting. This case series explores the application of an extended flap in immediate implant placement within type III sockets, specifically anterior maxilla healthy patients. A...

A small magnetic peg, named "BracketPeg," has been developed as an attachment magnet for implant prostheses. This study aimed to determine the feasibility of measuring stability at prosthesis level, evaluate reliability and accuracy BracketPeg, examine consistency measurements obtained using other devices damping capacity assessment (DCA) resonance frequency analysis (RFA). Forty implants were installed into artificial bone blocks, with each block representing 1 4 different diameters (3.5,...

This study aimed to evaluate the osteogenic capacity of two types collagenated xenogenic bone grafts (OCS-B Collagen®, NIBEC, Jincheon, Korea and Bio-Oss® Collagen, Geistlich, Wolhusen, Switzerland) in artificial defects beagle dogs. The bilateral mandibular premolars 13 male beagles were extracted, followed by creation standardized bony after 4 weeks. grafted with or without covered a collagen membrane. Dental implants placed 24 weeks post grafting. Bone regeneration osseointegration...

Receptor activator of nuclear factor-κB ligand (RankL) is a potent osteoclastogenic cytokine the expression which regulated at transcriptional level by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], protein kinase A (PKA) activators such as PTH and transmembrane glycoprotein 130 (gp130)-activating cytokines oncostatin M. We recently identified five highly conserved chromatin domains located significant distances upstream RankL start site that contribute to ability 1,25-(OH)2D3 its receptor enhance...

Purpose:The aim of this study was to determine the relationship between buccal bone thickness and gingival by means a noninvasive relatively accurate digital registration method.Methods: In 20 periodontally healthy subjects, cone-beam computed tomographic images intraoral scanned files were obtained.Measurements at central incisors, lateral canines performed points 0-5 mm from alveolar crest on superimposed images.The Friedman test used compare for each depth 3 tooth types.Spearman's...

Purpose: Lower urinary tract symptoms (LUTS) can be distressing and socially isolating, the economic impact substantial.Further data to characterize epidemiology effects of LUTS in South Korea would beneficial. Materials Methods:In an international, internet-based survey, prevalence was evaluated adults aged ≥40 years.Questions related International Continence Society (ICS) symptom definitions bother associated with each symptom.The international prostate score (IPSS) overactive bladder...

Migraine headache is an episodic phenomenon, and patients with migraine have ictal (headache), peri-ictal (premonitory, aura, postdrome), interictal (asymptomatic) phases. We aimed to find the functional characteristics of brain regardless phase using dynamic connectivity analysis. prospectively recruited 50 age- sex-matched controls. All subjects underwent a resting-state magnetic resonance imaging. Significant networks were defined in data-driven fashion from (>48 hours apart phases)...

Salivary diagnostic using matrix metalloproteinase (MMP) and S100 for periodontitis is a promising issue. However, its prognostic effect still unclear. This study aimed to evaluate the ability of salivary MMP-9 S100A8 through non-surgical treatment clinical trial.Total 149 participants, 99 50 healthy, were recruited. Among 74 participants revisited after three months. Periodontitis was classified as stage II-IV new classification proposed at 2018. Enzyme-linked immunosorbent assay kit used...