A5100644397- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Heat shock proteins research
- Protease and Inhibitor Mechanisms
- Sirtuins and Resveratrol in Medicine
- Enzyme Structure and Function
- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound and Hyperthermia Applications
- Protein Structure and Dynamics
- Hydrogen's biological and therapeutic effects
- Adipose Tissue and Metabolism
- Cancer Research and Treatments
- Neonatal Respiratory Health Research
- Glutathione Transferases and Polymorphisms
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Ferroptosis and cancer prognosis
- Biomarkers in Disease Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Radiation Therapy and Dosimetry
Korea Institute of Radiological and Medical Sciences
2015-2025
Soonchunhyang University
2014-2023
Korea University
2018-2020
Seoul St. Mary's Hospital
2018-2019
Catholic University of Korea
2018-2019
Inje University Busan Paik Hospital
2017
Inha University
2015
Chungbuk National University
2015
Dana-Farber Cancer Institute
2009-2014
Harvard University
2009-2014
Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM) enhance tumor in mice subcutaneous tumors patients with non-small cell lung cancer (NSCLC). We found a strong correlation between CD68 TAM immunostaining PET 18fluoro-deoxyglucose (FDG) uptake 98 matched of NSCLC. also observed significant glycolytic gene signatures 513 NSCLC from The Cancer Genome Atlas database. secreted TNFα to...
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy. We report that radiation-induced endothelial-to-mesenchymal transition (EndMT) leads to with abnormal SMA+NG2+ pericyte recruitment during regrowth after radiotherapy. Trp53 (but not Tgfbr2) deletion in endothelial cells (ECs) inhibited EndMT, reducing and metastases a high CD44v6+ cancer-stem-cell (CSC) content Osteopontin, an EndMT-related angiocrine factor suppressed by EC-Trp53 deletion,...
To investigate the change in 89 patients' pain and anxiety following implant surgery to evaluate correlation among anxiety, pain, influencing factors.Eighty-nine patients were included this study. Subjective factors perception from overall dental treatment (scored on Dental Anxiety Scale [DAS]) relative time surgery. Objective sex, age, location number. Patients completed questionnaires just before (T0), immediately after (T1), 1 day (T2), week (T3).The average was highest at T2, followed by...
Agastache rugosa (Fisch. & C.A.Mey.) Kuntze (Korean mint) is used to treat diverse types of human disorders in traditional medicine. In recent years, its non-fermented leaf extract (ARE) has been shown possess protective properties against ultraviolet-B (UV-B) radiation-induced photooxidative stress. The present work aimed examine whether probiotic bacterial fermentation would potentiate the skin anti-photoaging activity ARE or not, by comparing and corresponding fermented (ARE-F) UV-B...
Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in regulation mitosis. A null mutant or knockdown caused defective mitotic progression. By monitoring chromosomes living cells, determined that was localized centrosome mitosis especially spindle poles metaphase. phosphorylated Plk1 at Ser(216) DSGXXS motif during timing a phospho-defective form inhibited...
To measure the cortical and cancellous bone densities of palatal area in adolescents adults to compare quality among placement sites temporary anchorage devices.One hundred twenty cone beam computerized tomography scans were obtained from 60 (mean age, 12.2 ± 1.9 years) (24.7 4.9 years). The measurements density made Hounsfield units (HU) at 72 intersections eight mediolateral nine anterioposterior reference lines using InVivoDental software. Repeated-measures analysis variance was used...
Liver damage upon exposure to ionizing radiation, whether accidental or because of therapy can contribute liver dysfunction. Currently, radiation is used for various cancers including hepatocellular carcinoma; however, the treatment dose limited by poor tolerance radiation. Furthermore, reliable biomarkers predict and associated side-effects are unavailable. Here, we investigated fibrinogen-like 1 (FGL1)-expression in plasma after exposure. We found that 30 Gy irradiation (IR) induced cell...
Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 PF therapeutic strategy inhibition not well elucidated.We have developed a mouse model simulating clinical stereotactic body radiotherapy (SBRT) with focal irradiation validated induction RIPF. HSP25 (murine form HSP27) transgenic (TG) LLC1-derived orthotropic lung tumor models were also used. Lung tissues patients RIPF idiopathic fibrosis, from various...
Abstract The intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyzes the interconversion of active glucocorticoid (cortisol) and its intrinsically inert form (cortisone) in metabolic tissues. Although 11βHSD1 is considered a promising therapeutic target disorders such as 2 diabetes, obesity, nonalcoholic steatohepatitis because hepatic functions, roles other tissues have received less attention. In this study, we show that 11βHSD1-specific inhibitor J2H-1702...
Cancer therapies attempt to destroy the entire tumor, but this tends require toxic compounds and high doses of radiation. Recently, considerable attention has focused on therapy-induced senescence (TIS), which can be induced in cancer cells by low therapeutic drugs or radiation provides a barrier tumor development. However, molecular mechanisms governing TIS remain elusive. Special been paid potential chemopreventive effect aspirin against human colorectal cancer. In study, we investigated...
Hepatic ketogenesis plays an important role in catabolism of fatty acids during fasting along with dietary lipid overload, but the mechanisms regulating this process remain poorly understood. Here, we show that Cdc2-like kinase 2 (Clk2) suppresses acid oxidation and ketone body production diet-induced obesity. In lean mice, hepatic Clk2 protein is very low strongly increased feeding; however, obese remains elevated through both fed fasted states. Liver-specific knockout mice a high-fat diet...
ABSTRACT Objectives: To evaluate the changes in position of maxillary dentition and airway space after distalization using a modified C-palatal plate (MCPP) adult patients through CBCT images to analyze relationship between amount space. Materials Methods: 33 Class II (22.2 ± 4.0 years old; 27 women 6 men) treated by total arch MCPP were evaluated before distalization. The divided into nonextraction extraction groups. as well positions evaluated. effects calculated assessed paired t-tests....
Radiation-induced pulmonary fibrosis (RIPF) is a long-term side effect of thoracic radiation therapy. Hypoxia-induced vascular endothelial mesenchymal transition (EndMT) can occur during the development RIPF. Here, we examined direct contribution HIF-1α (EC-HIF1α) on RIPF.An inducible Cre-lox-mediated Hif1a deletion mouse line was used to evaluate potential inhibition suppress To effects pharmacologic inhibitor RIPF after image guided therapy (IGRT) for spontaneous lung adenocarcinoma,...
Targeting the molecular pathways underlying cardiotoxicity associated with thoracic irradiation and doxorubicin (Dox) could reduce morbidity mortality these anticancer treatments. Here, we find that vascular endothelial cells (ECs) persistent DNA damage induced by Dox treatment exhibit a fibrotic phenotype (endothelial-mesenchymal transition, EndMT) correlating colocalization of L1CAM foci. We demonstrate anti-L1CAM antibody Ab417 decreases overexpression nuclear translocation show in...
Radiation-induced skin injury (RISI) is a main side effect of radiotherapy for cancer patients, with vascular damage being common pathogenesis acute and chronic RISI. Despite the severity RISI, there are few treatments it that in clinical use. 2-Methoxyestradiol (2-ME) has been reported to regulate radiation-induced endothelial-to-mesenchymal transition. Thus, we investigated 2-ME as potent anti-cancer hypoxia-inducible factor 1 alpha (HIF-1α) inhibitor drug prevents RISI by targeting...
In a recent stereotactic body radiation therapy animal model, pneumonitis and pulmonary fibrosis were observed at around 2 6 weeks, respectively. However, the molecular signature of this model remains unclear. This study aimed to examine characteristics these two stages using RNA-seq analysis. Transcriptomic profiling revealed distinct transcriptional patterns for each stage. Inflammatory response immune cell activation involved in both stages. Cell cycle processes type II interferons during...
Cellular senescence is a physiological program of irreversible growth arrest that considered to play an important role in tumor suppression. Recent studies demonstrated senescent cells secrete multiple regulatory proteins could alter the behavior neighboring cells. In this study, we investigated effect secretory from ionizing radiation (IR) induced on normal and Conditioned medium (CM) IR-induced MCF7 significantly increased cell proliferation, invasion, migration, wound healing activity...