A5112337975- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Oceanographic and Atmospheric Processes
- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Particle Detector Development and Performance
- Hepatocellular Carcinoma Treatment and Prognosis
- Marine and coastal ecosystems
- Radiation Therapy and Dosimetry
- Supramolecular Self-Assembly in Materials
- Advanced Optical Sensing Technologies
- Consumer Perception and Purchasing Behavior
- Lanthanide and Transition Metal Complexes
- CCD and CMOS Imaging Sensors
- Fashion and Cultural Textiles
- Plasma Diagnostics and Applications
- Ocular and Laser Science Research
- Cultural and Historical Studies
Korea Atomic Energy Research Institute
2020-2025
Korea University of Science and Technology
2025
Seoul National University
2012-2021
Stanford University
2019-2021
Seoul National University Hospital
2016-2021
Sangmyung University
2020
Yonsei University
2014
Materials Science & Engineering
2014
Sun Moon University
2014
Korea University
2013
Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM) enhance tumor in mice subcutaneous tumors patients with non-small cell lung cancer (NSCLC). We found a strong correlation between CD68 TAM immunostaining PET 18fluoro-deoxyglucose (FDG) uptake 98 matched of NSCLC. also observed significant glycolytic gene signatures 513 NSCLC from The Cancer Genome Atlas database. secreted TNFα to...
Abstract Personalized dosimetry with high accuracy is crucial owing to the growing interests in personalized medicine. The direct Monte Carlo simulation considered as a state-of-art voxel-based technique; however, it incurs an excessive computational cost and time. To overcome limitations of approach, we propose using deep convolutional neural network (CNN) for voxel dose prediction. PET CT image patches were used inputs CNN given ground truth from Carlo. predicted rate maps compared...
Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding treatment human diseases. However, no single biomedical imaging modality provides complete information, resulting in emergence multimodal approaches. Combining state-of-the-art PET MRI technologies without loss system performance overall image quality can provide opportunities for new scientific clinical innovations. Here, we present a multiparametric PET/MR imager based on small-animal...
We propose a depth-of-interaction (DOI)-encoding method to extract continuous DOI information using single-layer scintillation crystal array with single-ended readout for cost-effective high-resolution positron emission tomography (PET). is estimated by different light dispersions along the x- and y-directions tailored geometric shape of reflectors around crystals. The detector module comprised 22 × unpolished LGSO crystals (2.0 2.0 20 mm3). A multi-anode photomultiplier tube 64 anodes...
Personalized dosimetry with high accuracy is becoming more important because of the growing interest in personalized medicine and targeted radionuclide therapy. Voxel-based using dose point kernel or voxel S-value (VSV) convolution available. However, these approaches do not consider heterogeneity medium. Here, we propose a new method for whole-body voxel-based heterogeneous media nonuniform activity distributions—a refer to as multiple VSV approach. Instead only single VSV, found water,...
Purpose: In this study, the authors present a silicon photomultiplier (SiPM)-based positron emission tomography (PET) insert dedicated to small animal imaging with high system performance and robustness temperature change. Methods: The consists of 64 LYSO-SiPM detector blocks arranged in 4 rings 16 yield ring diameter mm axial field view 55 mm. Each block 9 × array LYSO crystals (1.2 1.2 10 mm3) monolithic SiPM array. each is monitored, proper bias voltage applied according reading real time...
Monitoring environmental radiation around nuclear facilities is critical for safety and regulatory compliance. Traditional methods, such as monitoring using high-pressure ion chambers thermoluminescent dosimeters, have limitations with regard to cost, complexity, response time. To address these issues, we developed a compact Geiger–Müller (GM) counter-based detector network real-time at the Korea Atomic Energy Research Institute (KAERI). The GM module operated battery solar panel ensure...
Abstract Objective: This study aims to enhance positron emission tomography (PET) imaging systems by developing a continuous depth-of-interaction (DOI) measurement technique using single-ended readout. Our primary focus is on reducing the number of readout channels in scintillation detectors while maintaining accurate DOI estimations, high-pass filter-based signal multiplexing combined with artificial neural networks (ANNs).
Approach: Instead reading out all 64 signals from an 8×8...
Abstract DNA structures have gained much attention due to its ease of self‐assembly and precise controllability. Although technology has been successfully applied generate a variety structures, there are only few attempts apply inorganic materials lack controllability interactions between materials. In addition, the synthesis predictable structure hybrid still remains significant challenge. To address challenge, here novel strategy for DNA‐based superstructures using polymerase is reported....
Abstract We have developed a scalable detector readout design for 100 ps coincidence time resolution (CTR) of flight (TOF) positron emission tomography (PET) technology. The basic scintillation detectors studied in this paper are based on 2 × 4 arrays 3 10 mm ‘fast-LGSO:Ce’ crystals side-coupled to 6 silicon photomultipliers (SiPMs). employed novel mixed-signal front-end electronic configuration and low timing jitter Field Programming Gate Array-based digital converter data acquisition....
Positron emission tomography (PET) detectors with the ability to encode depth-of-interaction (DOI) information allow us simultaneously improve spatial resolution and sensitivity of PET scanners. In this study, we propose a DOI detector based on stair-pattern reflector arrangement inserted between pixelated crystals single-ended scintillation light readout. The main advantage proposed method is its simplicity; decoded from flood map data can be simply acquired by using readout system. Another...
The 18 kDa translocator protein (TSPO) has been proposed as a biomarker for the detection of neuroinflammation. Although various PET probes targeting TSPO have developed, highly selective probe detecting is still needed because single nucleotide polymorphisms in human gene greatly affect binding affinity ligands. Here, we describe visualization neuroinflammation with multimodality imaging system using our recently developed TSPO-targeting radionuclide [18F]CB251, which less affected by...
Photon time-of-flight (TOF) capability in positron emission tomography (PET) enables reconstructed image signal-to-noise ratio (SNR) improvement. With the coincidence time resolution (CTR) of 100 picosecond (ps), a five-fold SNR improvement can be achieved with 40 cm diameter imaging subject, relative to system without TOF capability. This ps CTR for clinically relevant detector design (crystal element length ≥20 mm reasonably high crystal packing fraction) using side-readout PET...
We present the first experimental evaluation of a depth-of-interaction (DOI) positron emission tomography (PET) detector using digital silicon photomultiplier (dSiPM). To measure DOI information from mono-layer array scintillation crystals with single-ended readout, our group has previously proposed and developed new method based on light spread triangular reflectors. Since this relies measurement distribution, dSiPM, which fully interface, several merits for measurement. The PET comprised...
Gadolinium aluminum gallium garnet (GAGG) is a promising scintillator crystal for positron emission tomography (PET) detectors owing to its advantages of energy resolution, light yield, and absence intrinsic radiation. However, large portion the incident photons undergoes Compton scattering within GAGG because low stopping power compared that lutetium-based crystals such as Lu2SiO5 (LSO). Inter-detector (IDS) inter-crystal (ICS) result in loss sensitivity image quality PET, respectively. We...
Positron Emission Tomography (PET) reconstructed image signal-to-noise ratio (SNR) can be improved by including the 511 keV photon pair coincidence time-of-flight (TOF) information. The degree of SNR improvement from this TOF capability depends on time resolution (CTR) PET system, which is essentially variation in arrival differences over all coincident pairs detected for a point positron source placed at system center. CTR determined several factors intrinsic properties scintillation...
Purpose Time‐of‐flight ( TOF ) information in positron emission tomography PET scanners enhances the diagnostic power of scans owing to increased signal‐to‐noise ratio reconstructed images. There are numerous additional benefits reconstruction, including simultaneous estimation activity and attenuation distributions from data only. Exploring further gains by using is important because it can broaden applications expand our understanding techniques. Herein, we present a prototype scanner with...
Internal dosimetry is of critical importance to obtain an accurate absorbed dose-response relationship during preclinical molecular imaging and targeted radionuclide therapy (TRT). Conventionally, dose calculations have been performed using organ-level based on the Medical Radiation Dose (MIRD) schema. However, recent research has focused developing more voxel-level calculation methods. Geant4 application for emission tomography (GATE) Monte Carlo (MC) a simulation toolkit gaining attention...
Voxel-based dosimetry is potentially accurate than organ-based because it considers the anatomical variations in each individual and heterogeneous radioactivity distribution organ. Here, voxel-based for 177 Lu-DOTATATE therapy was performed using single multiple voxel S-value (VSV) methods compared with Monte Carlo simulations. To verify these methods, we adopted sequential single-photon emission computed tomography X-ray (SPECT/CT) dataset acquired from Sunway Medical Centre major vendor's...
In this study, we developed a proof-of-concept prototype PET system using pair of depth-of-interaction (DOI) detectors based on the proposed DOI-encoding method and digital silicon photomultiplier (dSiPM). Our novel cost-effective DOI measurement is triangular-shaped reflector that requires only single-layer pixelated crystal single-ended signal readout. The detector consisted an 18 × array unpolished LYSO (1.47 1.47 15 mm3) wrapped with reflectors. information was encoded by depth-dependent...
We have evaluated CTR performance of four different mixed-signal front-end electronic readout configurations with the goal to achieve 100 picoseconds (ps) coincidence time resolution (CTR). The proposed TOF-PET detector elements are based on two 3 × 10 mm3 "fast LGSO" crystal segments, side-coupled linear arrays mm2 silicon photomultipliers (SiPMs), form a total length 20 mm. studied multiple and components for readout: 1) high speed radio frequency (RF) amplifiers; 2) an ASIC-based...