A5077443022- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Antibiotic Resistance in Bacteria
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Osteoarthritis Treatment and Mechanisms
- Oral microbiology and periodontitis research
- Salmonella and Campylobacter epidemiology
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Planarian Biology and Electrostimulation
- Thyroid Disorders and Treatments
- Dental Implant Techniques and Outcomes
- Trauma and Emergency Care Studies
- Bone and Dental Protein Studies
- Antibiotics Pharmacokinetics and Efficacy
Khyber Girls Medical College
2024-2025
Khyber Medical College
2024-2025
Hayatabad Medical Complex
2024-2025
Khyber Medical University
2021-2025
Qurtuba University of Science and Information Technology
2024
University at Buffalo, State University of New York
2016-2023
COMSATS University Islamabad
2018-2023
National Guard Health Affairs
2018-2023
Institut de Virologie
2021
PSG INSTITUTE OF TECHNOLOGY AND APPLIED RESEARCH
2021
The severity of tissue injury in burn wounds from associated inflammatory and immune sequelae presents a significant clinical management challenge. Among various biophysical wound approaches, low dose biophotonics treatments, termed Photobiomodulation (PBM) therapy, has gained recent attention. One the PBM molecular mechanisms treatments involves photoactivation latent TGF-β1 that is capable promoting healing regeneration. This work examined efficacy full-thickness C57BL/6 mice. We first...
Background and objectives: Subclinical hypothyroidism is an asymptomatic condition with normal thyroxin raised thyroid stimulating hormone (TSH) level. The objective of the study was to determine prevalence subclinical in primary health care (PHC) settings Riyadh explore relationship TSH level age, gender, family history, body mass index, co-morbid conditions.Subjects methods: A cross-sectional adult visitors nine satellites PHC clinics military housing carried out. concentration free T4...
Nanofibrous engineered matrices have significant potential in cellular differentiation and tissue regeneration. Stem cells require specific extracellular signals that lead to the induction of different lineages. However, mechanisms by which nanofibrous matrix promotes mesenchymal stem cell (MSC) are largely unknown. Here, we investigated underlie matrix-induced odontoblastic human dental pulp MSCs (DP-MSCs). An electrospun polystyrene (PSF) was prepared, responses PSF were assessed...
Mucormycosis is a serious fungal infection associated with uncontrolled diabetes and immunocompromised patients. This angioinvasive emerged as post-covid complication worldwide especially in developing countries. Due to the common socio-demographic status of South Asian countries, we expected surge mucormycosis cases Pakistan. study aims observe frequency survival Covid patients at tertiary care hospitals Pakistan during third wave Covid-19 2021.
The major difference between tissue healing and regeneration is the extent of instructional cues available to precisely direct biological response. A classic example reparative or osteodentin that seen in response physicochemical injury pulp-dentin complex. Dentin can differentiation dental stem cells using concerted actions both soluble (biomolecules, agonists, antagonists) insoluble (matrix topology) cues. purpose this study was examine synergistic combination two discrete biomaterial...
Recent studies have identified the regulatory mechanism of collagen in bone ossification and resorption. Due to its excellent bio-mimicry property, is used for treatment several joint disease such as arthritis, osteoporosis, osteopenia. In bone, biological action highly influenced by interactions other materials glycosaminoglycan minerals. view above perceptions, was crosslinked with chitosan, hydroxyapatite (H), chondroitin sulfate (Cs), produce a natural bone-like 3D structure evaluate...
Joint defects associated with a variety of etiologies often extend deep into the subchondral bone leading to functional impairment and joint immobility, it is very challenging task regenerate bone-cartilage interface offering significant opportunities for biomaterial-based interventions improve quality life patients. Herein drug-/bioactive-loaded porous tissue scaffolds incorporating nano-hydroxyapatite (nHAp), chitosan (CS) either hydroxypropyl methylcellulose (HPMC) or Bombyx mori silk...
Hydrogels can provide instant relief to pain and facilitate the fast recovery of wounds. Currently, incorporation medicinal herbs/plants in polymer matrix is being investigated due their anti-bacterial wound healing properties. Herein, we novel combination chitosan (CS) chondroitin sulfate (CHI) synthesize hydrogels through freeze gelation process enriched it with garlic (Gar) by soaking juice for faster resistance microbial growth at surface. The synthesized were characterized via...
Pulp-Dentin regeneration is a key aspect of maintain tooth vitality and enabling good oral-systemic health. This study aimed to investigate nanofibrous scaffold loaded with small molecule i.e. Tideglusib promote odontogenic differentiation. (GSK-3β inhibitor) interaction GSK-3β was determined using molecular docking stabilization β-catenin examined by confocal microscopy. 3D scaffolds were fabricated through electrospinning their physicochemical characterizations performed. Scaffolds seeded...
Abstract Collagen is widely used for dental therapy in several ways such as films, 3D matrix, and composites, besides traditional Chinese medicine (TCM), has been tissue regeneration wound healing application centuries. Hence, the present study was targeted first time to fabricate collagen film with TCM resveratrol celastrol order investigate human periodontal ligament fibroblasts (HPLF) growth bone marrow macrophages (BMM) derived osteoclastogenesis. Further, physicochemical, mechanical...
Prolyl hydroxylase (PHD) inhibitors are suggested as therapeutic agents for tissue regeneration based on their ability to induce pro-angiogenic responses. In this study, we examined the effect of PHD inhibitor dimethyloxalylglycine (DMOG) odontoblast maturation and sought determine underlying mechanism using MDPC-23 odontoblast-like cells. DMOG significantly enhanced matrix mineralization, confirmed by alizarin red staining measurement calcium content. dose-dependently increased alkaline...
Cementum is a mineralized layer on the tooth’s root surface and facilitates biomechanical anchoring of fibrous connective tissues as part tooth-supportive complexes. Previously, we observed that OCCM30 cementoblasts cultured fibrin matrices underwent apoptosis due to degradation through expression proteases. Here, demonstrated (OCCM30-fibrin) enhanced canonical Wnt signaling, which directed plasminogen expression. The OCCM30-fibrin showed higher levels Wnt3a expression, nuclear translocation...
A recent study reported the expression of receptor activator nuclear factor-κB (RANK) in mesenchymal stem cells (MSCs) surface that negatively regulates osteogenesis MSCs. Empirical evidence from previous confirmed role parathyroid hormone-related protein (PTHrP) osteoblastogenesis. However, it is necessary to understand paracrine PTHrP and RANKL for order explore hidden secrets bone biology. Considering above concept, cues soluble-receptor ligand (sRANKL) osteogenic differentiation MSCs...