A5087453924- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Dermatology and Skin Diseases
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Nasal Surgery and Airway Studies
- Pediatric health and respiratory diseases
- Oral and Maxillofacial Pathology
- Olfactory and Sensory Function Studies
- Bone Tumor Diagnosis and Treatments
- Immune Response and Inflammation
- Meningioma and schwannoma management
- Infectious Diseases and Mycology
- interferon and immune responses
- Medical Imaging and Pathology Studies
- Head and Neck Cancer Studies
- Cardiovascular and Diving-Related Complications
- Reconstructive Facial Surgery Techniques
- Air Quality and Health Impacts
- Pituitary Gland Disorders and Treatments
- Urticaria and Related Conditions
Seoul National University Hospital
2015-2024
Seoul National University
2014-2024
Agency for Defense Development
2024
National University College
2017-2022
New Generation University College
2010-2022
Seoul National University Bundang Hospital
2009-2022
University of South Florida
2020
Icahn School of Medicine at Mount Sinai
2019
Kyung Hee University
2019
Kleijnen Systematic Reviews (United Kingdom)
2016-2017
Nasal polyposis implies a refractory clinical course in case of chronic rhinosinusitis (CRS). Although hypoxia is believed to be associated with nasal polyposis, little known about the mechanism underlying polypogenesis.To determine if drives by epithelial-to-mesenchymal transition (EMT).Immunoblotting, immunofluorescence, flow cytometry, and real-time polymerase chain reaction were performed evaluate EMT hypoxic markers human epithelial cells (hNECs) sinonasal tissues from patients CRS or...
Current treatment options for allergic rhinitis (AR) include allergen avoidance and environmental control, pharmacotherapy, nasal surgery immunotherapy. Among these, immunotherapy is the only therapeutic option that modifies fundamental immunologic mechanism by inducing desensitization. Specific has been used 1 century since 1911 subcutaneous (SCIT) demonstrated to be effective in asthma AR. However, SCIT several disadvantages such as inconvenience, invasiveness potentially severe systemic...
OBJECTIVE The endoscopic endonasal approach (EEA) is commonly used for the treatment of craniopharyngioma; therefore, it essential to analyze outcomes in order understand benefits and drawbacks. goal this paper was evaluate clinical features associated with approach. METHODS From July 2010 March 2016, 82 adult craniopharyngioma patients underwent an EEA at authors’ institution. Of these cases, intraoperative records immediate postoperative MR images were available 68 patients. systemized...
Here, we studied the IFN-regulated innate immune response against influenza A virus (IAV) infection in mouse lung and therapeutic effect of IFN-λ2/3 acute IAV infection. For viral infections, (WS/33, H1N1, PR8 H5N1) were inoculated into wild-type mice by intranasal delivery, mRNA level titer measured. To compare antiviral IFNs vivo lung, neutralizing antibodies recombinant used. After inoculation mice, peaked at 7 days postinfection, also reached its peak this time. We found that IFN-β...
Abstract Fungus ball is the most common form of non-invasive fungal sinusitis, and maxillary sinus commonly involved site. Maxillary fungus (MFB) accounts for a considerable proportion unilateral sinusitis. The prevalence MFB has recently increased; however, its contributing factors are unclear. This study analyzed association between dental implants. One hundred one patients who underwent surgery were divided into two groups based on surgical biopsy results: bacterial sinusitis (UBS, n =...
Background/Aims: The role of induction chemotherapy (IC) for eyeball preservation has not been established in head and neck squamous cell carcinoma (HNSCC) the paranasal sinus nasal cavity (PNSNC). Periorbital involvement frequently leads to exenteration with a margin safety. We evaluated treatment outcomes, including survival preservation, patients who received IC HNSCC PNSNC. Methods: reviewed 21 diagnosed PNSNC were treated IC. analyzed response, rate, overall survival. Results: Tumors...
Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease characterized by involvement of diverse types cells. Asian CRS patients frequently show infiltration neutrophils an elevated level interferon (IFN)-γ; contrast, western exhibit eosinophil enhanced levels Th2-related cytokines. Neutrophilia in tissues decreases sensitivity to corticosteroids, but the mechanisms underlying progression neutrophilic are unclear. In this study, we investigated role IFN-γ with...
Abstract Objectives/Hypothesis: Although precise localization of obstruction sites in the upper airway during sleep is essential subjects with obstructive apnea syndrome (OSAS), no gold standard diagnostic method has been established. This study aimed to evaluate dynamic collapse inside by using cine magnetic resonance imaging (MRI), also called MRI. Study Design: Cross‐sectional retrospective data. Methods: The changes transverse and anteroposterior diameters retrolingual were studied a...
children.The application of limited number allergens could be possible for patients since the rate sensitization to some is quite low and differs based on age.This an important concept when epidemiologic study required.Knowledge composition minimally required SPT panel difference dependent age essential factor a reliable survey.A recent Global Allergy Asthma European Network demonstrated patterns different
Although continuous positive airway pressure (CPAP) is the most effective treatment modality, poor adherence still remains a problem for obstructive sleep apnea (OSA) and there little evidence regarding how this might be improved. This study aims to analyze anatomic clinical factors of OSA subjects who failed comply with CPAP therapy.The medical records 47 received therapy as first-line modality were retrospectively reviewed. The reviewed demographic polysomnographic data findings nasal...
Purpose We first analyzed the prognostic power of albumin-to-alkaline phosphatase ratio (AAPR) before radical radiotherapy (RT) in non-metastatic nasopharyngeal carcinoma (NPC) patients. Materials and Methods The records 170 patients with biopsy-proven, NPC treated by RT between 1998 2016 at our institution were retrospectively reviewed. Median follow-up duration was 50.6 months. All received intensity-modulated cisplatin based chemotherapy before, during, or after RT. major treatment on...
The lateral pharyngeal wall is recognized as an important site of upper airway collapse during sleep in patients with obstructive apnea (OSA), and expansion sphincter pharyngoplasty (ESP) may have promising clinical utility OSA collapse.To evaluate the therapeutic outcomes ESP conjunction other surgical procedures to investigate indications for OSA.Cohort study 63 diagnosed under drug-induced endoscopy who underwent combined tonsillectomy, uvuloplasty, or nasal surgery at Seoul National...
Sinonasal inverted papilloma (IP) is a neoplasm in the nasal cavity, characterized by its local aggressiveness and tendency to cause malignancy. Despite frequent recurrence of IP, few studies have reported effects situational parameters including smoking on rate IP. This study was performed evaluate clinical environmental factors that can predict after surgery patients with IP.This conducted retrospectively 132 who were diagnosed IP between November 1985 September 2007. The focused risk...
Background This study was designed to evaluate the necessity of postoperative nasal packing and find factors relevant in determining if required after endoscopic sinus surgery (ESS). Methods From January 2007 through June 2007, 64 consecutive patients who underwent ESS were evaluated. The decision whether or not perform depended on surgeon's judgment bleeding surgery. Demographic characteristics, medical history, disease extent, surgical procedures, subjective objective amount intraoperative...
Sublingual immunotherapy (SLIT) has recently received much attention around the world as a treatment for allergic rhinitis. This study aimed to investigate efficacy and adverse effects of SLIT in Korean patients with rhinitis caused by house dust mites. The compliance patient satisfaction were also assessed.The who sensitized Dermatophagoides pteronyssinus farinae started between November 2007 July 2008 included this study. symptom questionnaires, which items on rhinorrhea, sneezing, nasal...