A5066830349- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Sinusitis and nasal conditions
- Cerebrospinal fluid and hydrocephalus
- Nasal Surgery and Airway Studies
- Obstructive Sleep Apnea Research
- Cleft Lip and Palate Research
- Oral and Maxillofacial Pathology
- Craniofacial Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Growth Hormone and Insulin-like Growth Factors
- Allergic Rhinitis and Sensitization
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Infectious Diseases and Mycology
- Teratomas and Epidermoid Cysts
- Cerebral Venous Sinus Thrombosis
- Chromatin Remodeling and Cancer
- Ophthalmology and Eye Disorders
- Airway Management and Intubation Techniques
- Ear and Head Tumors
Thomas Jefferson University
2015-2025
Thomas Jefferson University Hospital
2015-2024
Jefferson University Hospitals
2019-2023
Neurological Surgery
2013-2023
University of Washington
2023
Triological Society
2021
Impact
2021
Philadelphia University
1995-2014
Medical Education Institute
2013
Albany Medical Center Hospital
2013
Abstract Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology. 1 Patients afflicted have a higher risk malignancies such as papillary carcinoma. 2 In present study, we investigated frequency carcinoma specific genes in patients diagnosed disease. The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful markers early stages they are highly for malignant cells. Using sensitive reverse transcriptase‐polymerase chain reaction (RT‐PCR) assay,...
Repair of the skull base still begins with a direct repair dural defect. We present new button closure for primary dura high flow defects.Retrospective review.We reviewed our 20 cases grafts and compared results to previous high-flow open-cistern cerebrospinal fluid (CSF) cases. Subjects were excluded if they had no violation arachnoid space or potential low-flow CSF leak. The is constructed so that inlay portion at least 25% larger than defect, onlay just large enough cover two are sutured...
Object Using strict biochemical remission criteria, the authors assessed surgical outcomes after endoscopic transsphenoidal resection of growth hormone (GH)–secreting pituitary adenomas and identified preoperative factors that significantly influence rate remission. Methods A retrospective review a prospectively maintained database was performed. The reviewed cases in which an GH-secreting cohort consisted 26 patients who had been followed for 3–60 months (mean 24.5 months). thresholds...
Abstract Objectives/Hypothesis: To review cases of endoscopic orbital apex and periorbital skull base surgery stratify the pathology lesion location. Variations in surgical technique outcomes are reviewed. We report results all over a 40‐month period. Eighteen with variety pathology, location apex, Study Design: Retrospective chart review. Methods: All period were Lesion location, approach, postoperative complications summarized. The details as well limitations advantages this approach...
To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.Retrospective chart review patients Thomas Jefferson University its affiliated hospitals.The charts 16 identified from databases pathology department were reviewed included in study.Sixteen (9 male 7 female, an average age 49.8 years) identified. The most common site amyloid involvement was larynx. Consequently, commonly presented hoarseness (14...
Elevation of the superficial musculoaponeurotic system (SMAS) with or without fat graft interposition during parotidectomy prevents a concave facial deformity and Frey's syndrome.Retrospective, case-control study.Charts for 248 patients who underwent were reviewed pathologic, radiographic, clinical, operative data. Sixteen SMAS elevation 34 included in two study groups. Nonreconstructed controls randomly selected from pool had unilateral, matched based on pathologic specimen volume. Patients...
OBJECTIVE There is a paucity of literature regarding the learning curve associated with performing endoscopic endonasal cranial base surgery. The purpose this study was to determine what extent might exist for resection in cases craniopharyngiomas. METHODS A retrospective review performed all craniopharyngioma resections at Thomas Jefferson University from 2005 2015. To assess effect, patients were divided into an early cohort (2005–2009, n = 20) and late (2010–2015, 23). Preoperative...
Background: Sinonasal malignancy makes up a small subset of head and neck cancers. Prognosis for this disease can vary depending on the pathology location tumor. The mainstay treatment these malignancies includes surgical resection with adjuvant radiotherapy or chemotherapy if necessary. It is unknown age plays role in increasing risk developing complications following resection. We aim to analyze impact systemic outcomes sinonasal including cranial base utilizing large national database.
Introduction: Postoperative endocrinopathy after surgical resection of craniopharyngioma can be expected given the tumor's proximity to hypothalamus and pituitary gland. While planning for these lesions depends on tumor characteristics, preference gross total (GTR) or subtotal (STR) followed by adjuvant radiotherapy (XRT) remains controversial in consideration recurrence-free survival increased postoperative comorbidities, namely endocrinopathy. Furthermore, incidence following stalk...
Patients with acromegaly present unique challenges to cranial base surgery and anesthesia teams in the perioperative period, especially regard airway management. Abnormal anatomy may result from soft tissue hypertrophy bony alterations. Additional relate management of medical comorbidities. We aim review concerns acromegalic patients for skull surgeon order reduce preventable complications.Case series chart review.Tertiary care academic institution.Thirty-two undergoing endoscopic...
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is often treated endoscopic sinus surgery (ESS); however, patients may require revision due to recurrence. To date, no studies have compared outcomes for combined and biologic therapy CRSwNP alone.
Microinjections of botulinum toxin have recently been shown to be effective in the treatment strabismus, and it has also suggested that microinjections this myoneural blocking agent might value spastic dysphonia. The success such a microinjection technique would rely on precise knowledge distribution junctions thyroarytenoid muscle. In view potential application as well need for information reinnervation procedures, we used computer graphics reconstruct three-dimensional motor end-plates...
Background Endoscopic transsphenoidal surgery (ETS) for the resection of pituitary adenoma has become more common throughout past decade. Although most patients have a short postoperative hospitalization, others require prolonged stay. We aimed to identify predictors hospitalization in setting ETS adenomas. Methods A retrospective chart review as performed on 658 undergoing at single tertiary care academic center from 2005 2019. Length stay (LoS) was defined date discharge. Patients with LoS...
The endoscopic endonasal approach to management of orbital pathology has expanded. Due the rarity these conditions, most reports in literature consist small case reports. We report a series from single institution with focus on outcomes.A retrospective chart review was carried out between 2010 and 2018.Twenty-four patients were identified (average age 58 years, 15 males, 9 females). Average follow-up 14.9 months. Most common etiologies included cavernous hemangioma (7), metastases (6),...
Abstract Background Post‐COVID parosmia may be due to dysautonomia and sympathetic hyperresponsiveness, which can attenuated by stellate ganglion block (SGB). This study evaluates SGB as a treatment for post‐COVID olfactory dysfunction (OD). Methods Retrospective case series with prospective data of patients OD undergoing unilateral (UL) or bilateral (BL) SGB. Patients completed Brief Smell Identification Tests (BSIT) (12 points maximum) post‐procedure surveys including severity scores on...
To evaluate the outcomes of endoscopic dacryocystorhinostomy (eDCR) with and without use ultrasonic bone aspirator (UBA; Sonopet).A retrospective, institutional review board approved chart all eDCRs over 49 months. Data included demographics, indication/etiologic factors nasolacrimal duct obstruction, comorbidities, intraoperative findings, epiphora symptoms pre- postoperatively, complications. Patients were grouped in eDCR or UBA.One hundred twenty-three primary 99 patients included, 59 UBA...
Abstract BACKGROUND In select cases, the endoscopic endonasal approach (EEA) has distinct advantages for resection of tuberculum sella meningiomas (TSM). OBJECTIVE To report extent (EOR), complication rates, and outcomes in a large series TSM treated by EEA. METHODS Twenty-five consecutive cases EEA from 2008 to 2016 were retrospectively reviewed. Patient history, imaging, volumetric EOR, complications, are presented. RESULTS Mean patient age was 53.9 yr, with female predominance (84%)....
Background Due to the diverse histopathologic features and variable survival rates seen in sinonasal undifferentiated carcinoma (SNUC), it is likely that this diagnostic entity comprised of a heterogonous group morphologically tumors. As advancements molecular testing have led better understanding tumor biology, has become increasingly evident SNUC may actually encompass several subtypes with different clinical behavior. result, also all patients cannot be treated same fashion. Recent...
Twenty‐nine patients were admitted to Pennsylvania Hospital between March 1984 and July 1990 with a diagnosis of epistaxis hereditary hemorrhagic telangiectasia. Data obtained through retrospective review the charts these patients. Patients treated for CO 2 laser, neodymium:aluminum garnet laser wavelength 1064 nm (Nd‐Yag), Nd‐Yag 532 (KTP), septodermoplasty, or any combination procedures. under‐went an average 2.5 procedures each. Overall, 25 29 reported their symptoms had greatly improved...