A5034957862- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Tracheal and airway disorders
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Meningioma and schwannoma management
- Olfactory and Sensory Function Studies
- Pituitary Gland Disorders and Treatments
- Ear and Head Tumors
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Respiratory and Cough-Related Research
- Salivary Gland Tumors Diagnosis and Treatment
- Surgical Simulation and Training
- Asthma and respiratory diseases
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- Esophageal and GI Pathology
- Bone Tumor Diagnosis and Treatments
- Facial Nerve Paralysis Treatment and Research
University of North Carolina at Chapel Hill
2016-2024
Piedmont Atlanta Hospital
2024
Temple University
2024
Harvard University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Thomas Jefferson University Hospital
2023-2024
Thomas Jefferson University
2024
University of North Carolina Health Care
2020
University of North Carolina Hospitals
2018-2019
Sir Ganga Ram Hospital
2018
Background Over 550,000 sinus surgeries are performed annually in the United States on patients with chronic rhinosinusitis (CRS). Although results of surgery vary widely, no known genetic factor has been identified to predict surgical outcomes. The bitter taste receptor T2R38 recently demonstrated regulate upper airway innate defense and may affect patient responses therapy. Our goal was determine whether TAS2R38 genetics predicts outcomes CRS following surgery. Methods A prospective study...
Abstract Background Poor oral health has been identified as a prognostic factor potentially affecting the survival of patients with head and neck squamous cell carcinoma. However, evidence to date supporting this association emanated from studies based on single cohorts small-to-modest sample sizes. Methods Pooled analysis 2449 carcinoma participants 4 International Head Neck Cancer Epidemiology Consortium included data periodontal disease, tooth brushing frequency, mouthwash use, numbers...
The aetiology and outcomes for patients with acquired subglottic stenosis are highly variable. This study aimed to identify risk factors patient characteristics that predict long-term clinical outcomes.A retrospective review was performed on 63 age-matched controls. Patient demographics were compared. Subglottic further grouped according tracheostomy status (i.e. never required, initially required but eventually decannulated, tracheostomy-dependent). from these three groups then compared...
Malignant sinonasal and skull base tumors are now being resected using an endoscopic technique, but there has been controversy regarding the oncologic safety of this approach. Various studies have compared outcomes from surgery to those open techniques; however, all limited by substantial differences in patient populations receiving each In study we compare techniques use propensity score matching control for these populations.Retrospective cohort including patients > 18 years old primary...
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is often treated endoscopic sinus surgery (ESS); however, patients may require revision due to recurrence. To date, no studies have compared outcomes for combined and biologic therapy CRSwNP alone.
Endoscopic endonasal repair of cerebrospinal fluid (CSF) rhinorrhea secondary to idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri or benign hypertension, has varying success rates, from 25-87%, with minimal morbidity. However, often these series have a relatively short-term follow-up. Given the pathophysiology IIH, long-term follow-up is necessary identify true CSF leak recurrence rates. Our investigation aimed evaluate outcomes in endoscopically repaired leaks.A...
To assess the effect that implementation of a multimodal analgesic plan has on opioid requirements and pain control in head neck (H&N) surgery patients.Prospective cohort.Tertiary academic hospital.An institutional review board (IRB)-approved quality improvement initiative was undertaken to implement protocol for all admitted H&N patients starting November 2017. Postprotocol data from January May 2018 were compared preprotocol October Data obtained electronic health records as well through...
Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor, displaying aggressive behavior with frequent recurrence and metastasis. Little information exists regarding the impact of clinicopathological parameters adjuvant radiotherapy (aRT) on ACC disease specific (DSS) overall survival (OS). We extracted demographic, treatment, 1439 patients major or minor intraoral from Surveillance, Epidemiology, End Results (SEER) database. The associations between tumor characteristics aRT OS DSS...
Abstract Background Post‐COVID parosmia may be due to dysautonomia and sympathetic hyperresponsiveness, which can attenuated by stellate ganglion block (SGB). This study evaluates SGB as a treatment for post‐COVID olfactory dysfunction (OD). Methods Retrospective case series with prospective data of patients OD undergoing unilateral (UL) or bilateral (BL) SGB. Patients completed Brief Smell Identification Tests (BSIT) (12 points maximum) post‐procedure surveys including severity scores on...
Abstract Objective While most patients with COVID‐19‐induced olfactory dysfunction (OD) recover spontaneously, those persistent OD face significant physical and psychological sequelae. ChatGPT, an artificial intelligence chatbot, has grown as a tool for patient education. This study seeks to evaluate the quality of ChatGPT‐generated responses COVID‐19 OD. Study Design Quantitative observational study. Setting Publicly available online website. Methods ChatGPT (GPT‐4) was queried 4 times 30...
The purpose of this study was to assess the utility imaging and endoscopy in posttreatment surveillance sinonasal malignancies.We conducted a retrospective analysis primary malignancies diagnosed between 2000 2014. Posttreatment included nasal (MRI, CT, positron emission tomography [PET]/CT). Positive predictive value (PPV), negative (NPV), specificity, sensitivity were calculated for each modality compared.One hundred nine identified with 30 recurrences. Endoscopy showed specificity 24%...
Clinical trials that deintensify treatment for patients with suspected human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) use p16 expression to identify HPV-mediated tumors and guide treatment. While staining has a strong correlation good outcomes, approximately 12% of p16-positive have recurrent disease. Biomarkers reveal tumor-specific characteristics, such as nodal involvement, may change therapy decisions.To assess whether if genetic signature exists...
To determine drivers of the racial disparity in stage at diagnosis and overall survival (OS) between black white patients with HPV-negative head neck squamous cell carcinoma (HNSCC).
Background Enhanced Recovery After Surgery (ERAS) protocols have been developed and successfully implemented for many surgical specialties, demonstrating reductions in length of stay, post‐operative complications, resource utilization. Currently, there are few documented applications ERAS head neck surgery. Additional description surgery protocol design, implementation, outcomes will help advance postoperative care. Methods An was designed patients undergoing glossectomy primary or salvage...
The bitter taste receptor T2R38, expressed in the tongue and nasal epithelium, has been shown to trigger sinonasal innate immunity contributing prevention of gram-negative upper airway bacterial infections. Common polymorphisms T2R38 gene, correlating with sensitivity phenylthiocarbamide (PTC), have linked differences immune response, specific genotypes significantly more common medically recalcitrant chronic rhinosinusitis patients. purpose this study was examine association between...
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose this study was to present our single-institution case series neck leiomyosarcoma review cases in National Cancer Data Base (NCDB).Patients with at University Pennsylvania NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, outcomes evaluated for prognostic significance.Nine patients from institution identified; majority had high-grade disease cutaneous leiomyosarcoma, 5-year survival rate...
Understanding the independent predictors of poor outcomes in free flap surgery is essential for patient selection. We aim to determine major complications, survival, and extended hospital stays.Retrospective cohort study.Tertiary medical center.We reviewed records from all vascularized tissue transfers head neck between 2007 2014 at our institution. recorded demographics, comorbidities, disease characteristics, intraoperative events. defined as complications 30-day postoperative period,...