A5011061985- Genomic variations and chromosomal abnormalities
- Sinusitis and nasal conditions
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Nasal Surgery and Airway Studies
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Salivary Gland Tumors Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Chronic Lymphocytic Leukemia Research
- Tumors and Oncological Cases
- Ear and Head Tumors
- Innovations in Medical Education
- Streptococcal Infections and Treatments
- Asthma and respiratory diseases
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Otolaryngology and Infectious Diseases
- Obstructive Sleep Apnea Research
- Cystic Fibrosis Research Advances
- Autism Spectrum Disorder Research
- Clinical Reasoning and Diagnostic Skills
- Medical Malpractice and Liability Issues
- Head and Neck Surgical Oncology
Thomas Jefferson University Hospital
2023-2024
Harvard University
2022-2024
Temple University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Boston University
2023-2024
Boston Children's Hospital
2020-2022
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is often treated endoscopic sinus surgery (ESS); however, patients may require revision due to recurrence. To date, no studies have compared outcomes for combined and biologic therapy CRSwNP alone.
Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more influenced by genetic factors than adult-onset However, the prevalence effect CNVs in EOP unclear.The authors documented recurrent functional impact deletions duplications genome-wide 137 children adolescents compared 5,540 individuals autism spectrum disorder (ASD) 16,504 population control...
This study examines the impact of dupilumab on medication use for chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma patients. Patients had a reduction in oral/inhaled/topical steroids, antibiotics, leukotriene receptor antagonists (LTRAs). The no total polyp or SNOT-22 scores.
Abstract Background Olfactory dysfunction (OD) affects many survivors of COVID‐19. Prior studies have investigated the use platelet‐rich plasma (PRP) injections for OD. We describe first randomized controlled trial investigating topical PRP OD treatment and contribute to existing literature illustrating as an emerging therapeutic. Methods This is a single‐blinded, conducted from July 2022 December 2023. Adult patients with ≥6 months secondary COVID‐19 Brief Smell Identification Test (BSIT)...
Importance Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence. Objective To evaluate the oncologic outcomes and with positive margins. Design, Setting, Participants The American Head Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 2019 at 41 centers. Margins were classified as R0 (negative), R1 (microscopically positive), or R2 (macroscopically...
Abstract Mendelian and early-onset severe psychiatric phenotypes often involve genetic variants having a large effect, offering opportunities for discoveries early therapeutic interventions. Here, the index case is an 18-year-old boy, who at 14 years of age had decline in cognitive functioning over course year subsequently presented with catatonia, auditory visual hallucinations, paranoia, aggression, mood dysregulation, disorganized thoughts. Exome sequencing revealed stop-gain mutation...
This is the largest study in North America investigating olfactory outcomes after pituitary surgery to date.
Background 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use patient “self-phenotyping” survey collect data directly patients further characterize the syndrome. Objective This aimed (1) discover self-identified in underrepresented...
Objective: Physicians experience scary cases in the course of usual medical practice. Cases near misses, legal and ethical dilemmas, or unique clinical challenges are great sources education. However, there is no format for presentation dissemination that do not meet criteria morbidity mortality (M&M) conferences. The Scary Conference an innovative educational forum scrutiny analysis these challenging cases. differs from traditional Morbidity Mortality conferences as it explores outcomes...
Abstract Objective Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity. Study Design Retrospective database review. Setting TriNetX US database. Methods Collaborative Network was queried for cohorts patients with OSA, CRS, and CRS comorbid OSA (CRS‐OSA). Data included demographics, severity assessed via rates endoscopic sinus surgery (ESS), antibiotic, oral steroid use. Propensity score matching performed to account differences in demographics...
Abstract This is the first study to examine chronic rhinosinusitis (CRS) outcomes after starting immunoglobulin (Ig) replacement therapy for patients with primary (PID) and secondary immunodeficiency (SID). a retrospective review of diagnosed CRS from 2018 2022 prior initiating Ig treatment PID or SID. Outcomes included medication use Sinonasal Outcome Test (SNOT‐22) scores. Ten met inclusion criteria. SID had decrease in antibiotics (PID: 9.40 3.20, P = .05, SID: 8.20 2.00, .04) steroids...
<sec> <title>BACKGROUND</title> 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use patient “self-phenotyping” survey collect data directly patients further characterize the syndrome. </sec> <title>OBJECTIVE</title> This aimed (1) discover...