A5001240715- Polyomavirus and related diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Full-Duplex Wireless Communications
- Ear and Head Tumors
- Antenna Design and Analysis
- Reconstructive Surgery and Microvascular Techniques
- Oral and Maxillofacial Pathology
- Inflammatory mediators and NSAID effects
- Tracheal and airway disorders
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Tumors and Oncological Cases
- Cleft Lip and Palate Research
- Estrogen and related hormone effects
- Medical Practices and Rehabilitation
- Plant Virus Research Studies
- Lymphatic System and Diseases
- Reconstructive Facial Surgery Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Sinusitis and nasal conditions
- Cancer and Skin Lesions
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
Medical University of Vienna
2011-2021
Evangelisches Krankenhaus Alsterdorf
2020
University Health Network
2012-2015
Princess Margaret Cancer Centre
2012-2015
Ontario Institute for Cancer Research
2013
Cancer Institute (WIA)
2013
Health Sciences Centre
2012
Sunnybrook Health Science Centre
2011-2012
University of Toronto
2011-2012
Pediatric Oncology Group
2012
The purpose of this study was to evaluate the clinical outcome in patients with benign parotid gland tumors after extracapsular dissection or superficial parotidectomy (SP).Eight hundred ninety-four primary pleomorphic adenoma Warthin's tumor were included from study. Type and length surgery, size, resection margins, complication rates assessed.Three ninety-five (44.2%) dissections 499 SPs (55.8%) performed. rate positive margins significantly higher compared SP group (29.4% vs 10.2%; p <...
VEGF proteins and their receptors are involved in tumor vessel neoformation. The third receptor, VEGFR3 (flt-4) is important during both blood development lymphatic formation. Because HNSCC preferentially metastasizes to regional lymph nodes, we investigated the expression of its ligand VEGF-C head neck squamous cell carcinomas by semiquantitative RT-PCR (4 cells lines 6 specimens) immunohistochemistry (18 specimens). protein was confirmed Western blotting four six specimens.Semiquantitative...
The microvascular anastomosis remains a technically sensitive and critical determinant of success in free tissue transfer. anastomotic coupling device is an elegant, friction-fit ring pin that becoming more widely used.To systematically review the literature to examine utility coupler transfer.A comprehensive database search was performed identify eligible publications. Inclusion criteria were utilization free-tissue Recorded information from studies included patient age, follow-up,...
To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital.Clinical outcome of two hundred fifteen malignancies was evaluated over a 16-year period.Two-hundred-fifteen adenoid cystic carcinoma (n = 20), adenocarcinoma 19), acinic cell 62), basal 7), carcinoma-ex-pleomorphic adenoma 18), mucoepidermoid 70) and salivary duct 19) have been included. The 5- 10-year overall disease-free survivals 80.62%/69.48% 74.37%/62.42%,...
ABSTRACT Fosfomycin is a broad-spectrum antibiotic which established as therapy for uncomplicated lower urinary tract infections. In addition, preliminary data indicate that fosfomycin has potential role in the treatment of soft tissue However, use not been this condition, and it unclear whether level penetration into human tissues high enough to eradicate relevant pathogens. To better characterize fosfomycin, we applied combined vivo pharmacokinetic-in vitro pharmacodynamic model...
Activation of the hedgehog pathway may contribute to carcinogenesis. This study characterizes expression pattern in squamous cell carcinoma skin and head neck.Tissue microarrays were constructed with samples neck. All tissue immunohistochemically stained for 7 Hedgehog molecules.Significant (p < .0001) overexpression all evaluated molecules could be observed tumor compared healthy control tissues. Expression Gli-2 showed significant upregulation that Smoothened Patched downregulation neck...
Abstract Background The purpose of this study was to discuss the appropriate management options for parathyroid carcinomas, which is still a subject controversy. Methods A retrospective chart review 16 patients with carcinoma undertaken determine clinical outcome. Results All were initially treated surgery, and 11 received adjuvant radiotherapy. 5‐ 10‐year disease‐specific survival rates 100% 80%, respectively; disease‐free 69% 43%, respectively. locoregional control 52%, distant 89% 74%, In...
The aim of this study was to prospectively evaluate volume change in anterolateral thigh free flaps pre- and postradiotherapy compare computed tomography (CT) volumetric analysis with intraoperative water displacement calculation.Matched pair cohort study.Thirteen patients advanced carcinoma the parotid gland underwent flap reconstruction following total parotidectomy resections neck dissection. Before initiation external beam radiation, routine CT planning scans were done on all patients. A...
Since the first description of Merkel cell carcinoma by Cyril Toker in 1972, number studies has significantly increased over last 4 decades. In this review, we will illustrate historical background beginning with 19th century, to finding CK20 as a highly specific diagnostic marker and finally recently detected polyomavirus (MCPyV). Moreover, highlight adjuvant therapeutic regimens radiotherapy chemotherapy discuss work-up including imaging histology patients carcinoma. Another very rapidly...
To characterize the potential of ciprofloxacin penetration into human soft tissues following intravenous (i.v.) and oral (p.o.) administration, we measured free concentrations in interstitial space fluid skeletal muscle subcutaneous adipose tissue by microdialysis. In addition, were cantharis-induced skin blisters, saliva, capillary plasma compared to total venous plasma. Furthermore, a pharmacodynamic vitro model was used simulate vivo pharmacokinetics bacterial culture. Eight healthy...
Vascular endothelial growth factor receptor 2 (VEGFR2; Flk-1 [fetal liver kinase]/KDR [kinase insert domain containing receptor]) has been identified as a high affinity for vascular (VEGF) on endothelium. Head and neck squamous cell carcinomas (HNSCC) have already shown to produce substantial amounts of VEGF. VEGFR2 is supposed play major role in tumor-neoangiogenesis.We investigated 24 tumor specimens 4 HNSCC cultured lines the incidence distribution by immunohistochemistry using monoclonal...
BMI-1 is involved in the maintenance of stem cells and functions as an oncogene both lymphomas solid carcinomas, acting by downregulation p16ink4a. We have investigated expression profile normal inflamed skin well basal cell carcinomas (BCCs) squamous (SCCs).BMI-1 was determined immunohistochemistry immunofluorescence, evaluated semiquantitatively.BMI-1 weakly expressed nuclei sometimes suprabasal keratinocytes, sebaceous glands, to moderately bulge area external root sheath hair follicles,...
The Hedgehog signaling pathway is important for human development and carcinogenesis in various malignancies.One tissue microarray with triplets of 28 samples from 25 patients Merkel cell carcinoma (MCC) was constructed. Six normal skin 5 oral mucosa served as controls. All were analyzed immunohistochemically antibodies directed against Sonic hedgehog, Indian Patched, Smoothened, Gli-1, Gli-2, Gli-3.All investigated proteins frequently intensely overexpressed MCCs (Sonic 93%; 84%; 86%; 79%;...
Abstract Objectives/Hypothesis: The aim of this study was to assess whether the use temporoparietal fascia as a free flap for pharyngeal closure reinforcement reduced incidence pharyngocutaneous fistula (PCF) in salvage setting. Study Design: Consecutive case series. Methods: After research ethics board approval, 12 patients who required laryngectomy, including covera g e primarily closed defect with tissue transfer, were analyzed. Results: One (8%) out experienced that responded...
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumor of the skin with mortality rate approximately 25% (Peloschek et al., 2010). Accurate assessment nodal involvement in patients MCC predicts significantly overall outcome (Smith 2012 and Ortin-Perez 2007). Due to rarity this highly disease, only few imaging reports on were published, subsequently still date no accepted algorithm for available. For primary staging MCC, general recommendations have included ultrasonography,...
Abstract Background The purpose of this study was to determine the expression pattern Merkel cell polyomavirus (MCPyV) large T‐protein antigen in patients with carcinoma. Methods A tissue microarray (TMA) containing 30 specimens constructed and stained for MCPyV T protein. Immunohistochemical determined semiquantitively compared patients' outcome. Results Nuclear protein detected 29 (97%). In particular, 60% 100%, 30% 60%, 10% tumor cells were positive 27 (90%), 1 (3%), respectively. There...