A5073527837- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Head and Neck Cancer Studies
- Urinary Tract Infections Management
- Neonatal and Maternal Infections
- Microbial Natural Products and Biosynthesis
- Ear and Head Tumors
- Dysphagia Assessment and Management
- Allergic Rhinitis and Sensitization
- Neurological Complications and Syndromes
- Tracheal and airway disorders
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Sinusitis and nasal conditions
- Metabolism, Diabetes, and Cancer
- Pituitary Gland Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Endodontics and Root Canal Treatments
- Voice and Speech Disorders
- Cutaneous lymphoproliferative disorders research
Thomas Jefferson University Hospital
2024-2025
Thomas Jefferson University
2024-2025
Loyola University Chicago
2024
Loyola University Medical Center
2024
University of California, San Diego
2020-2022
Arlington Center for Dermatology
2021
La Jolla Alcohol Research
2020
Abstract Objective We aim to explore the differences in complication rates endoscopic versus open transcervical treatment of Zenker diverticulum. Study Design Retrospective Cohort from January 1, 2015 December 31, 2023. Setting Queries TriNetX database's United States Collaborative Network. Methods A retrospective cohort study was conducted using patients ≥18 years old diagnosed with diverticulum selected Patients undergoing and diverticulectomy between 2023 were identified divided into...
Background: Sinonasal malignancy makes up a small subset of head and neck cancers. Prognosis for this disease can vary depending on the pathology location tumor. The mainstay treatment these malignancies includes surgical resection with adjuvant radiotherapy or chemotherapy if necessary. It is unknown age plays role in increasing risk developing complications following resection. We aim to analyze impact systemic outcomes sinonasal including cranial base utilizing large national database.
Introduction: Postoperative endocrinopathy after surgical resection of craniopharyngioma can be expected given the tumor's proximity to hypothalamus and pituitary gland. While planning for these lesions depends on tumor characteristics, preference gross total (GTR) or subtotal (STR) followed by adjuvant radiotherapy (XRT) remains controversial in consideration recurrence-free survival increased postoperative comorbidities, namely endocrinopathy. Furthermore, incidence following stalk...
Certain populations such as diabetic individuals are at increased risk for developing urinary tract infections (UTI), although the underlying reasons this susceptibility not fully known. Additionally, diabetics more likely to become infected with certain types of bacteria, group B Streptococcus (GBS). In study, we find that an antimicrobial peptide called cathelicidin, which is thought protect bladder from infection, ineffective in controlling GBS and alters type immune cells migrate during...
Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly; however, factors that govern GBS persistence disease severity this niche are not fully understood. Here, we report presence fungus Candida albicans, urogenital colonizer, can promote UTI. Co-inoculation with C. albicans increased adherence to bladder epithelium promoted colonization vivo adhesin-dependent manner. This study...
The threat to public health posed by drug-resistant bacteria is rapidly increasing, as some of healthcare’s most potent antibiotics are becoming obsolete. Approximately two-thirds the world’s derived from natural products produced Streptomyces encoded biosynthetic gene clusters. Thus, identify novel clusters, we sequenced genomes four bioactive strains isolated soil in San Diego County and used Bacterial Cytological Profiling adapted for agar plate culturing order examine mechanisms...
Antibiotic-laden calcium sulfate beads are gaining popularity in the treatment of orthopaedic infections such as fracture-related infection and osteomyelitis. Calcium have several advantages over polymethylmethacrylate (PMMA) they bioabsorbable, demonstrated improved elution characteristics, lower peak polymerization temperatures than seen PMMA. The ability to make store antibiotic for later use has potential standardize dosing decrease operating room times healthcare costs. This study aims...
Anticoagulants (AC) are associated with epistaxis in atrial fibrillation (AF) patients. Left appendage occlusion (LAAO) is a treatment that allows AF patients to stop AC. The aim of this study evaluate the risk developing following LAAO versus direct oral anticoagulants (DOAC) and warfarin.
Antibiotics are a mainstay of modern medicine, but as they kill their target pathogen(s), often affect the commensal microbiota. Antibiotic-induced microbiome dysbiosis is growing research focus and health concern, assessed via analysis fecal samples. However, such does not inform how antibiotics influence across whole host or changes subsequently alter chemistry. In this study, we investigated acute (1 day postadministration) delayed (6 days effects single parenteral dose two common...
Background: Spontaneous cerebrospinal fluid leaks (sCSF leak) represent a distinct cohort of patients with idiopathic intracranial hypertension (IIH). Previous observational studies have demonstrated that individuals sCSF tend to be older and possess higher body mass index (BMI), as well exhibit dyslipidemia. Patients may not demonstrate classic symptoms associated IIH due natural pressure release from the leak. Existing literature is primarily observational, limited by small sample sizes,...
Background: Chronically elevated intracranial pressure (ICP) can lead to the development of skull base defects and spontaneous cerebrospinal fluid leaks (sCSF). Venous sinus stenting (VSS) has emerged as a promising treatment option for patients with sCSF leak in setting IIH. There is lack literature discussing impact on symptomatology quality life after VSS IIH CSF leak. This first study explore effects venous symptoms
Background: Spontaneous cerebrospinal fluid (CSF) leaks may occur in a subset of patients with idiopathic intracranial hypertension (IIH). Current literature highlights that some not display the typical IIH characteristics, including papilledema or significantly elevated opening pressures lumbar puncture, due to natural pressure release from leak. There is lack consensus on neuroimaging findings and spontaneous CSF leak (IIHwL) without (IIHwoL). This study seeks better characterize...
Background: Poor surgical ergonomic practices can result in musculoskeletal strain and chronic injury. Previous studies have demonstrated that wearable devices like the "Upright Go" (UG) improve posture with real-time feedback among otolaryngologists. Prior not assessed long-term impact of these on complaints after biofeedback is removed, nor any correlated improvements changes pain. This first study to utilize UG evaluate ergonomics pain rhinologic surgery.
Background: Given the rarity and heterogeneity of sinonasal malignancies (SNM), specifics SNM treatment vary across institutions providers. The timing neck dissection in patients who have has not been previously studied. Challenges performing a on same day include increased length surgery time coordination multiple surgical teams. However, delayed may lead to radiation require recoveries from surgery. This is first study examine its impact patient outcomes requiring anterior cranial base...
Background: It has long been recognized that the host immune system plays a role in progression and survival of patients with melanoma. Regression is an immunological phenomenon described cutaneous melanoma whereby tumor replaced tumor-infiltrating lymphocytes (early regression), immature fibroblasts granulation tissue (intermediate mature (late regression) often accompanied by pigment incontinence (accumulation melanin upper dermis) pigment-laden macrophages. Melanin deposited macrophages...
Abstract Introduction Social disparities is known to have a significant impact on health outcomes including those related obstructive sleep apnea (OSA). More recently metric as area deprivation index (ADI) which combines 17 social determinants of has been used better quantify this impact. We aim examine the relationship between socioeconomic and CPAP adherence among adults with OSA using ADI. Methods Retrospective chart review patients diagnosis prescribed from Oct-Dec 2022. Patients were...
<h3>Background</h3> Several recent window-of-opportunity trials (WOT) have demonstrated the feasibility of immune checkpoint inhibitors (ICIs) in a neoadjuvant setting for early-stage resectable head and neck squamous cell carcinoma (HNSCC). Previous research suggests age may influence efficacy ICI, reporting comparable or improved responses to ICIs older patients treated recurrent/metastatic HNSCC.<sup>1 2</sup> We investigate age-related differences response ICI therapy HPV+ HNSCC...
<h3>Background</h3> Previous studies have shown metformin modulates the tumor microenvironment (TME) by increasing inflammatory response through upregulation of CD8+ tumor-infiltrating lymphocytes and restoration MHC I expression. This suggests a potential benefit in treating various cancers cytotoxic activity. However, there is scarce literature regarding as neoadjuvant therapy head neck squamous cell carcinoma (HNSCC). To investigate metformin's anti-tumor activity HNSCC TME, we performed...
<h3>Background</h3> Head and Neck Cancer (HNC) is the sixth most common malignant tumor worldwide, with incidence rates continuing to rise.<sup>1</sup> The search for novel biomarkers combination therapies ongoing, alongside efforts elucidate pathways affected by these treatments. Neutrophil-to-Lymphocyte Ratio (NLR) a biomarker associated poorer overall survival in HNC patients has been used characterize inflammatory response cancer.<sup>2 3</sup> This study investigates immune modulated...
BACKGROUND: Elevated intracranial pressure can cause skull base defects and a spontaneous cerebrospinal fluid leak (CSF). Venous sinus stenting (VSS) has emerged as promising treatment option for patients with CSF in the setting of idiopathic hypertension (IIH). There is lack literature on symptomatology quality life (QOL) after VSS IIH leak. This study explores effects symptoms QOL METHODS: retrospective who have complicated by underwent VSS. A questionnaire was developed from migraine...
Background Regression is an immunological phenomenon described in cutaneous melanoma whereby tumor replaced with tumor‐infiltrating lymphocytes, granulation tissue, and mature fibroblasts often accompanied by pigment incontinence (accumulation of melanin the upper dermis). Pigment results grossly pigmented lesions that may be mistaken for viable has not been sinonasal mucosal (SNMM). This study investigates presence regression patients SNMM. Methods A retrospective chart review was conducted...
Tumors involving the vagus nerve are often clinically silent. We offer a case series with different clinical presentations and distinctive post-surgical sequelae that highlight some of challenges associated managing cervical vagal tumors.