A5068180808- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Dental materials and restorations
- dental development and anomalies
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Salivary Gland Disorders and Functions
- Dental Trauma and Treatments
- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- Magnolia and Illicium research
- Oral and gingival health research
- Tissue Engineering and Regenerative Medicine
- Bone and Dental Protein Studies
- Protease and Inhibitor Mechanisms
- Silk-based biomaterials and applications
- Proteoglycans and glycosaminoglycans research
- 3D Printing in Biomedical Research
- Laser Applications in Dentistry and Medicine
- Rheumatoid Arthritis Research and Therapies
- Orthodontics and Dentofacial Orthopedics
Seoul National University
2016-2025
Seoul National University Dental Hospital
2006-2023
Pusan National University
2016
University of California, Los Angeles
2001
Background: The present study was undertaken to evaluate the potential of periodontal ligament stem cells (PDLSCs) and bone marrow SCs (BMSCs) on alveolar regeneration in a canine peri‐implant defect model. Methods: Four adult, male beagle dogs were used this study. Autologous BMSCs from iliac crests PDLSCs extracted teeth cultured. Three months after extraction, BMSC‐ PDLSC‐loaded hydroxyapatite/β‐tricalcium phosphate (HA/TCP) (test groups) cell‐free HA/TCP (control group) implanted three...
Purpose: Implant stability at the time of surgery is crucial for long-term success dental implants.Primary considered paramount importance to achieve osseointegration.The purpose present study was investigate correlation between insertion torque and primary implants using artificial bone blocks with different densities compositions mimic circumstances that are encountered in routine daily clinical settings.Methods: In order validate objectives, various sized holes were made (#10, #20, #30,...
In this study we investigated not only osteoblastic cell proliferation and differentiation on the surface of calcium metaphosphate (CMP) matrices in vitro but also bone formation by ectopic implantation these cell–matrix constructs athymic mice vivo. Interconnected porous CMP with pores 200 μm size were prepared to use as scaffolds for rat-marrow stromal-cell attachment. Cell–matrix cultured vitro, ALPase activities monitored 56 days. addition their being implanted into subcutaneous sites...
Background: To the best of our knowledge, influence external versus internal implant–abutment connections on crestal bone remodeling has not been reported. The aim present study is to investigate abutment connection peri‐implant levels (CBLs) using radiographic recordings. Methods: Radiographic recordings from 40 single‐tooth implants (20 and 20 octagonal connections; one implant/patient) in patients (15 males 25 females; mean age: 54.3 years) were selected for analyses. evaluation included...
Peri-implantitis is a chronic inflammatory process with advanced bone loss and impaired healing potential. For peri-implantitis treatment, tissue engineering can be applied to enhance regeneration of peri-implant defects. This study aimed evaluate ex vivo morphogenetic protein 2 (BMP2) gene delivery using canine periodontal ligament stem cells (PDLSCs) for Canine PDLSCs were transduced adenoviral vectors containing BMP2 (BMP2/PDLSCs). After was induced by ligature placement in six beagle...
A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation rheumatoid arthritis (RA).Two hundred sixty-four RA patients 88 age- sex-matched controls underwent dental exam. Additionally, manifestations including disease activity anti-citrullinated protein antibodies were evaluated in patients.The prevalence moderate or severe higher compared (63.6% vs 34.1%, p < 0.001). In markers periodontal inflammation, bleeding on...
Specific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which the key interplay to support mineralized tissues. Although 2D platforms or 3D printing systems can guide cellular activities aligned organizations, it remains a challenge develop ligament-guided, architectures with angular controllability parallel, oblique perpendicular cells organs. Here, we show use scaffold design by additive manufacturing...
ABSTRACT Aims Periodontal diseases pose significant challenges to oral health, making the regeneration of periodontal tissues a critical therapeutic goal. The goal is restore dental function by repairing damaged tissue and reconstructing healthy connective structure between teeth alveolar bone. This study aimed investigate effects selcopintide (SCPT) on differentiation ligament cells (PDLCs), cementoblasts, osteoblasts in vitro, as well using defect model dogs vivo. Methods expression marker...
To analyze the outcomes of a single- and double-layered collagen membrane on efficacy onlay block grafts in terms bone resorption augmentation.A total 36 New Zealand white rabbits were used this study. Calvarial blocks obtained from one side parietal fixed contaralateral side. The covered with either no (C group), (M1 or two (M2 group) layers non-cross-linked (BioGide((R))). After 2, 4, 6 months healing, sacrificed explanted specimens prepared for histologic histomorphometric analysis. At...
Purpose: It has been reported that low-level semiconductor diode lasers could enhance the wound healing process.The periodontal ligament is crucial for maintaining tooth and surrounding tissues in healing.While have used laser therapy, there few reports on their effects fibroblasts (PDLFs).We performed this study to investigate biological of human PDLFs.Methods: Human PDLFs were cultured irradiated with a gallium-aluminum-arsenate (GaAlAs) which wavelength was 810 nm.The power output fixed...
Bone tissue healing is a dynamic, orchestrated process that relies on multiple growth factors and cell types. Platelet-derived factor-BB (PDGF-BB) released from platelets at wound sites induces cellular migration proliferation necessary for bone regeneration in the early process. morphogenetic protein-2 (BMP-2), most potent osteogenic differentiation inducer, directs new formation of defects. This study evaluated combinatorial treatment protocol PDGF-BB BMP-2 critical-sized defect model. To...
The aim of this study is to compare the gene expression profile in mesenchymal stem cells derived from dental tissues and bone marrow for characterization cells. We employed GeneChip analysis levels approximately 32,321 kinds transcripts 5 samples bone-marrow-derived (BMSCs) (n=1), periodontal ligament (PDLSCs) (n=2), pulp (DPSCs) (n=2). Each cell was sorted by a FACS Vantage Sorter using immunocytochemical staining early surface marker STRO-1 before microarray analysis. identified 379...
Periodontitis (PD) has been reported to be associated with rheumatoid arthritis (RA). Porphyromonas gingivalis (P. gingivalis) is a gram-negative anaerobic bacterium that recognized as one of the major pathogenic organisms in PD and only known express peptidylarginine deiminase (PAD). Antibody against human α-enolase (ENO1) autoantibodies RA. ENO1 highly conserved protein, could candidate molecule for molecular mimicry between bacterial proteins. In present study, we measured serum antibody...
Purpose:The aim of this study was to determine the relationship between buccal bone thickness and gingival by means a noninvasive relatively accurate digital registration method.Methods: In 20 periodontally healthy subjects, cone-beam computed tomographic images intraoral scanned files were obtained.Measurements at central incisors, lateral canines performed points 0-5 mm from alveolar crest on superimposed images.The Friedman test used compare for each depth 3 tooth types.Spearman's...
Ultraviolet (UV) photofunctionalization has been suggested as an effective method to enhance the osseointegration of titanium surface. In this study, machined surface treated with UV light (M + UV) was compared sandblasted, large-grit, acid-etched (SLA) through in vitro and vivo studies. Groups specimens were defined (M), SLA, M for disc type, SLA implant. The discs implants assessed using scanning electron microscopy, confocal laser spectroscopy chemical analysis, contact angle....