A5100600177- Electrospun Nanofibers in Biomedical Applications
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Glioma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Pluripotent Stem Cells Research
- Bone and Dental Protein Studies
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
Kangwon National University
2022-2024
Chungnam National University
2015-2024
Ulsan College
2008-2024
Asan Medical Center
2008-2024
University of Ulsan
2008-2024
Soonchunhyang University
2011-2023
Convergence
2023
Nongwoo Bio (South Korea)
2023
Korea Institute of Materials Science
2022
Korea University
1998-2021
Majority of cancer cells upregulate co‐inhibitory molecule B7‐H1 which confers resistance to anti‐tumor immunity, allowing cancers escape from host immune surveillance. We addressed the molecular mechanism underlying regulation cancer‐associated expression in response interferon‐γ (IFN‐γ). Using promoter constructs luciferase assay, region between 202 and 320 bp translational start site is responsible for expression. Electrophoretic mobility shift site‐directed mutagenesis knockdown...
The most widespread dietary problem in the world is mineral deficiency. We used nicotianamine synthase ( NAS ) gene to increase contents rice grains. Nicotianamine (NA) a chelator of metals and key component metal homeostasis. isolated activation-tagged mutant lines which expression gene, OsNAS3 , was increased by introducing 35S enhancer elements. Shoots roots plants OsNAS3-D1 accumulated more Fe Zn. Seeds from our grown on paddy field contained elevated amounts (2.9-fold), Zn (2.2-fold),...
There have been no randomized studies comparing intravascular ultrasound (IVUS)-guided versus conventional angiography-guided chronic total occlusion (CTO) intervention using new-generation drug-eluting stent Therefore, we conducted a prospective, randomized, multicenter trial designed to test the hypothesis that IVUS-guided CTO is superior intervention.After successful guidewire crossing, 402 patients with CTOs were group (n=201) or and secondarily Resolute zotarolimus-eluting stents Nobori...
Abstract System x c − contributes to glutathione (GSH) synthesis and protects cells against ferroptosis by importing cystine exchanging it with glutamate. Transforming growth factor β1 (TGF-β1) induces redox imbalance; however, its role in system regulation remains poorly understood. The present study was the first show that TGF-β1 repressed protein mRNA levels of xCT, a catalytic subunit , PLC/PRF/5, Huh7, Huh6, HepG2 an early gene signature but not SNU387, SNU449, SNU475, SK-Hep1 late...
Abstract The electrospinning of polyglycolide (PGA), poly( L ‐lactide) (PLA), and poly(lactide‐ co ‐glycolide) (PLGA; ‐lactide/glycolide = 50/50) was performed with chloroform or 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) as a spinning solvent to fabricate their nanofiber matrices. morphology the electrospun PGA, PLA, PLGA nanofibers investigated scanning electron microscopy (SEM). nanofibers, nonpolar solvent, had relatively large average diameter (760 nm), it broad distribution in range...
Abstract A PVA nanofibrous matrix was prepared by electrospinning an aqueous 10 wt % solution. The mean diameter of the nanofibers electrospun from solution 240 nm. water resistance as‐spun improved physically crosslinking heat treatment at 150°C for min, which were found to be optimal conditions determined chemical and morphological considerations. In addition, heat‐treated (H‐PVA) coated with a chitosan construct biomimetic wound dressings. chitosan‐coated (C‐PVA) showed less hydrophilic...
Electrospinning of collagen (COL)/silk fibroin (SF) blend solutions in 1,1,1,3,3,3-hexafluoro-2-propanol was investigated for fabrication a biocompatible and biomimetic nanostructured scaffold tissue engineering. The morphology the electrospun COL/SF nanofibers observed by scanning electron microscopy. average diameters fibers ranged from 320 to 360 nm, irrespective SF content blends. Both COL components as-spun matrices were stabilized glutaraldehyde water vapor, respectively, under...
Lee SJ, McCall WD, Jr., Kim YK, Chung SC, JW: Effect of botulinum toxin injection on nocturnal bruxism: A randomized controlled trial. Objective: To evaluate the effect type bruxism. Design: Twelve subjects reporting bruxism were recruited for a double-blind, clinical Six bruxers injected with in both masseters, and six saline. Nocturnal electromyographic activity was recorded subject's natural sleeping environment from masseter temporalis muscles before injection, 4, 8, 12 wks after then...
We screened a chemical library in MCF-7 cells stably expressing green fluorescent protein (GFP)-conjugated microtubule-associated 1 light chain 3 (LC3) (GFP-LC3-MCF-7) using cell-based assay, and identified BIX-01294 (BIX), selective inhibitor of euchromatic histone-lysine N-methyltransferase 2 (EHMT2), as strong autophagy inducer. BIX enhanced formation GFP-LC3 puncta, LC3-II, free GFP, signifying autophagic activation. Inhibition these phenomena with chloroquine increasement punctate...
// Mi Jeong Heo 1 , Young Kim 1,2 Ja Hyun Koo Yoon Mee Yang Jihyun An 3 Sook-Kyung Lee 4 Seung Jin 5 Kang Mo Joong-Won Park and Sang Geon College of Pharmacy Research Institute Pharmaceutical Sciences, Seoul National University, Seoul, Korea; 2 Pharmacy, Hanyang Ansan, Gyeonggido, Department Internal Medicine, Asan Liver Center, Medical University Ulsan Center for Cancer, Cancer Goyang, Gachon Incheon, Korea Correspondence: Kim, email: Keywords : hepatocellular carcinoma; USP4; S1P1;...
Objective. Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) is one of the active components present in root and rhizome Rheum palmatum. It has been shown to contain biological activity (antitumour, antibacterial, diuretic vasorelaxant effects). However, mechanisms underlying anti-arthritic effect emodin have not elucidated. Here we investigated whether treatment would modulate severity disease an experimental arthritis model.
Ferroptosis is caused by the iron-mediated accumulation of lipid peroxidation, which distinct from apoptosis and necroptosis. Necrostatin-1 inhibits receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to initiate necroptosis; it also indoleamine 2,3-dioxygenase (IDO) regulate tumor immunity. However, few studies have examined off-target effect necrostatin-1 on ferroptosis pathway. The present study whether could interrupt induced system xc- inhibitors (sulfasalazine erastin) a...
With an aim to mimic natural extracellular matrix, we fabricated the nano- and microfibrous matrix with chitosan by electrospinning nanofibers onto predefined mesh for effective chondrocytes cultivation. Rolling double-layered nano-/microfibrous membranes produced three-dimensional (3-D) scaffolds that exhibited interconnected open pore structure in their scanning electron microscopy images. In vitro chondrocyte culture experiment showed this 3-D provided a significantly greater...