A5091185634- Magnetic properties of thin films
- Graphene research and applications
- Advanced Chemical Physics Studies
- Surface and Thin Film Phenomena
- Physics of Superconductivity and Magnetism
- Theoretical and Computational Physics
- Characterization and Applications of Magnetic Nanoparticles
- 2D Materials and Applications
- Genomics, phytochemicals, and oxidative stress
- Magnetic Properties and Applications
- Molecular Junctions and Nanostructures
- Advanced Memory and Neural Computing
- Adipose Tissue and Metabolism
- Quantum and electron transport phenomena
- Electron and X-Ray Spectroscopy Techniques
- Mycobacterium research and diagnosis
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Chemical and Physical Properties of Materials
- Advanced Thermoelectric Materials and Devices
- Boron and Carbon Nanomaterials Research
- Magnetic Properties of Alloys
- ZnO doping and properties
- Tuberculosis Research and Epidemiology
- Semiconductor materials and interfaces
Hanyang University
2021-2025
Anyang University
2025
Korea Research Institute of Standards and Science
2013-2023
Massachusetts General Hospital
2016-2021
Asan Medical Center
1990-2020
Pediatric Nephrology of Alabama
2020
Gachon University
2017-2020
Korea University of Science and Technology
2018
Seoul National University
1999-2016
Harvard University
2016
Nrf2 (nuclear factor erythroid 2-related 2) is an antioxidant transcription factor. AMP-activated protein kinase (AMPK) functions as a central regulator of cell survival in response to stressful stimuli. should be coordinated with the pathway controlled by AMPK, but so far mechanistic connections remain undefined. This study investigated role AMPK trafficking and its activity regulation. A subnetwork integrating neighbor molecules suggested direct interaction between Nrf2. In cells,...
Abstract System x c − contributes to glutathione (GSH) synthesis and protects cells against ferroptosis by importing cystine exchanging it with glutamate. Transforming growth factor β1 (TGF-β1) induces redox imbalance; however, its role in system regulation remains poorly understood. The present study was the first show that TGF-β1 repressed protein mRNA levels of xCT, a catalytic subunit , PLC/PRF/5, Huh7, Huh6, HepG2 an early gene signature but not SNU387, SNU449, SNU475, SK-Hep1 late...
Strong charge-spin coupling is found in a layered transition-metal trichalcogenide ${\mathrm{NiPS}}_{3}$, van der Waals antiferromagnet, from studies of the electronic structure using several experimental and theoretical tools: spectroscopic ellipsometry, x-ray absorption, photoemission spectroscopy, density functional calculations. ${\mathrm{NiPS}}_{3}$ displays an anomalous shift optical spectral weight at magnetic ordering temperature, reflecting strong between structures. X-ray...
Identifying material parameters affecting properties of ferromagnets is key to optimized materials that are better suited for spintronics. Magnetic anisotropy particular importance in van der Waals magnets, since it not only influences magnetic and spin transport properties, but also essential stabilizing order the two-dimensional limit. Here, we report hole doping effectively modulates a ferromagnet explore physical origin this effect. Fe3-xGeTe2 nanoflakes show significant suppression with...
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal excretion and reducing 1,25-dihydroxyvitamin D3 [1,25(OH)2D] production. Disorders of FGF23 homeostasis are associated with significant morbidity mortality, but fundamental understanding what regulates production lacking. Because the kidney major end organ action, we hypothesized it releases synthesis. Using aptamer-based proteomics liquid chromatography-mass...
The nuclear receptor liver X receptor-α (LXRα) stimulates lipogenesis, leading to steatosis. Nuclear factor erythroid-2-related factor-2 (Nrf2) contributes cellular defense mechanism by upregulating antioxidant genes, and may protect the from injury inflicted fat accumulation. However, whether Nrf2 affects LXRα activity is unknown. This study investigated inhibitory role of in hepatic molecular basis.A deficiency enhanced ability agonist promote steatosis, as mediated lipogenic gene...
Abstract Unidirectional motion of magnetic domain walls is the key concept underlying next-generation domain-wall-mediated memory and logic devices. Such has been achieved either by injecting large electric currents into nanowires or employing domain-wall tension induced sophisticated structural modulation. Herein, we demonstrate a new scheme without any current injection This utilizes recently discovered chiral walls, which exhibit asymmetry in their speed with respect to fields. Because...
Abstract Identification of precise prognostic marker and effective therapeutic target is pivotal in the treatment gastric cancer. In present study, we determined level RUNX3 expression cancer cells specimens impact its alteration on biology clinical outcome. There was a loss or substantial decrease protein 86 cases tumors as compared with that normal mucosa (P < 0.0001), which significantly associated inferior survival duration = 0.0005). Cox proportional hazards model, independently...
Nrf2 has an anti-carcinogenic effect. However, increase in activity is also implicated cancer chemoresistance. A switch from E-cadherin to N-cadherin affects the transdifferentiation and metastasis of cells. In view key role this malignancy, we investigated regulatory effect on Nrf2. HEK293 cells, overexpression inhibited nuclear accumulation Nrf2, prevented Nrf2-dependent gene induction. GST pull-down immunocytochemical assays verified interaction between Nrf2: bound C-terminus but not its...
Abstract The one-dimensional magnetic skyrmion motion induced by an electric current has attracted much interest because of its application potential in next-generation memory devices. Recently, the unidirectional large (20 μm diameter) bubbles with two-dimensional topology, driven oscillating field, also been demonstrated. For high-density devices, it is preferable to reduce size skyrmion. Here we show numerical simulation that a few tens nanometres can be high-frequency field oscillations,...
Abstract Van der Waals (vdW) magnets are an ideal platform for tailoring 2D magnetism with immense potential spintronics applications and intensively investigated. However, little is known about the microscopic origin of magnetic order in these antiferromagnetic systems. X‐ray photoemission electron microscopy used to address electronic properties vdW antiferromagnet FePS 3 down monolayer. The experiments reveal a giant out‐of‐plane anisotropy 22 meV per Fe ion, accompanied by unquenched...
We demonstrate that the controlled distribution of nanoparticles can be achieved by employing spin-coating method. The Co and Ag were uniformly distributed on Si SiO2 substrates with this particle density was controllable varying concentration colloids. spatial within patterned area also shown to uniform small boundary effect, which is favorable for current microelectronics technology. propose method utilized in developing mass production processes future nanodevices.
The skyrmion magnetic bubble in a ferromagnetic disk exhibits hypocycloidal gyrations contrary to the vortex gyration, showing simple circular trajectory. To describe mass term is needed Thiele's equation. In this study, we analytically derived both and spring constant term, which are crucial parameters for describing gyration. Values obtained by these analytic expressions were consistent with those simulations. We could find dependences of two terms on several external parameters, including...
We investigated the subdomain structures of single-layer graphene oxide (GO) by characterizing local friction and conductance using conductive atomic force microscopy. Friction mapping showed that a GO flake has subdomains several tens to few hundreds nanometers in lateral size. The exhibited low (high conductance) sp2-rich phase high (low sp3-rich phase. Current–voltage spectroscopy revealed current flow depends on quantity hydroxyl carboxyl groups, epoxy bridges within 2-dimensional carbon...
Abstract Background Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and mass control. Perturbation of the skeletal metabolism elevates risk variety diseases including disorders. However, regulatory pathways molecules are not completely understood. The discovery relevant responsible associated network could be an attractive strategy to overcome with problems. Methods An initial screening using quantitative trait locus...
The pathogenesis of psoriasis, an immune-mediated chronic skin barrier disease, is not fully understood yet. Here, we identified lysophosphatidic acid (LPA) receptor 5 (LPA5)-mediated signaling as a novel pathogenic factor in psoriasis using imiquimod-induced mouse model. Amounts most LPA species were markedly elevated injured mice, along with LPA5 upregulation skin. Suppressing the activity TCLPA5, selective antagonist, improved symptoms, including ear thickening, erythema, and scaling...
Initial adsorption configurations of acetylene molecules on the Si(001) surface are investigated by scanning tunneling microscopy (STM) and ab initio pseudopotential calculations. Three distinctive features observed in STM images at low coverage. The comparison atomic resolution with simulation reveals that there basically two kinds di-$\ensuremath{\sigma}$ bonding configurations: (i) on-top over a single dimer (ii) end-bridge between successive dimers same row. third feature is identified...
Galpha12 and Galpha13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response oxidative stress. This study investigated the regulation of Nrf2 by Galpha13. A deficiency Galpha12, but not Galpha13, enhanced activity target gene transactivation embryo fibroblasts. In mice, knockout activated thereby facilitated heme catabolism bilirubin its glucuronosyl conjugations. An oligonucleotide microarray...