A5106763006- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Ginseng Biological Effects and Applications
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Medicinal Plants and Bioactive Compounds
- Traditional Chinese Medicine Analysis
- Plant-derived Lignans Synthesis and Bioactivity
- Healthcare and Venom Research
- Hormonal Regulation and Hypertension
- Ginger and Zingiberaceae research
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Studies
- Histone Deacetylase Inhibitors Research
- Liver physiology and pathology
- Glutathione Transferases and Polymorphisms
- Phytochemistry and Biological Activities
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Diet, Metabolism, and Disease
- Cell death mechanisms and regulation
Dongguk University
2013-2025
Uijeongbu St. Mary's Hospital
2021-2025
Kyungpook National University
2003-2024
National Institute of Environmental Research
2021
Catholic University of Korea
2021
Daegu Haany University
2011-2020
Pusan National University
1997-2017
Seoul National University
2006-2017
Sungkyunkwan University
2012-2014
Yonsei University
2014
The Korea-United States Air Quality (KORUS-AQ) field study was conducted during May-June 2016. effort jointly sponsored by the National Institute of Environmental Research South Korea and Aeronautics Space Administration United States. KORUS-AQ offered an unprecedented, multi-perspective view air quality conditions in employing observations from three aircraft, extensive ground-based network, ships along with array forecast models. Information gathered is contributing to improved...
Recently, we demonstrated that myricetin exhibits cytoprotective effects against H2O2-induced cell damage via its antioxidant properties. In the present study, was found to inhibit apoptosis in Chinese hamster lung fibroblast (V79-4) cells, as shown by decreased apoptotic bodies, nuclear fragmentation, sub-G1 population, and disruption of mitochondrial membrane potential (Dym), which are increased H2O2-treated cells. Western blot data showed level Bcl-2, is an anti-apoptotic factor, levels...
Network pharmacology has emerged as a powerful tool to understand the therapeutic effects and mechanisms of natural products. However, there is lack comprehensive evaluations network-based approaches for products on identifying key mechanisms.
Nrf2 has an anti-carcinogenic effect. However, increase in activity is also implicated cancer chemoresistance. A switch from E-cadherin to N-cadherin affects the transdifferentiation and metastasis of cells. In view key role this malignancy, we investigated regulatory effect on Nrf2. HEK293 cells, overexpression inhibited nuclear accumulation Nrf2, prevented Nrf2-dependent gene induction. GST pull-down immunocytochemical assays verified interaction between Nrf2: bound C-terminus but not its...
Cadherins mediate cell-cell adhesion and catenin (ctn)-related signaling pathways. Liver fibrosis is accompanied by the loss of E-cadherin (ECAD), which promotes process epithelial-mesenchymal transition. Currently, no information available about inhibitory role ECAD in hepatic stellate cell activation. Because ECAD's potential for inhibiting induction transforming growth factor β1 (TGFβ1), we investigated whether overexpression prevents TGFβ1 gene induction; also examined what molecular...
Korean ginseng (Panax C.A. Meyer) has been used as a botanical medicine throughout the history of Asian traditional Oriental medicine. Formulated red (one form ginseng) shown to have antioxidant and chemopreventive effects.This study investigated cytoprotective effects mechanism action extract (RGE) against severe ROS production mitochondrial impairment in cytotoxic cell model induced by AA + iron.RGE protected HepG2 cells from iron-induced cytotoxicity preventing induction dysfunction...
Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for bioactivities of L. japonica, fucoxanthin (FX) considered potential antioxidant. This study was conducted to examine effects extract (LJE) or FX against oxidative stress on hepatocytes elucidate overall their cellular mechanisms effects. We constructed an vitro model with treatment arachidonic acid (AA) + iron HepG2 cells stimulate...
Context Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective Oxidative stress causative agent of liver inflammation may lead fibrosis hepato-carcinoma. In this study, we investigated the antioxidant effects emodin its mechanism.Materials methods We used hepatocyte stimulated by arachidonic acid (AA) + iron cotreatment C57B/6 mice orally injected with acetaminophen (APAP, 500 mg/kg, 6...
Acute and chronic liver disease are global problems with high morbidity mortality. Bupleuri Radix (BR) is an herbal medicine that has been prescribed empirically in traditional Asian to modulate metabolism. However, its active compounds therapeutic mechanisms remain unclear. Here, we integrated a network-based approach experimental validation elucidate BR's potential treating oxidative injury. Our incorporated data collection network construction utilizing bioinformatics tools, identified...
<title>Abstract</title> This study aimed to evaluate the biomechanical efficacy of rim plating for posterolateral tibia plateau fractures (PLTPFs) compared conventional posterior buttress plating. Sixty synthetic tibial models were divided into three groups: with a 3.5-mm locking compression T-plate, 2.7-mm variable-angle cloverleaf plate and two anteroposterior screws, alone. Static cyclic loading tests conducted assess mechanical stability under simulated physiological conditions. Failure...
Rosa hybrida has been demonstrated to exert biological effects on several cell types. This study investigated the efficacy of edible ethanol extract R. (EERH) against human colorectal carcinoma line (HCT116) cells. HCT116 cells were cultured with different concentrations EERH (0, 400, 600, 800, and 1,000 µg/mL) in Dulbecco's modified Eagle medium. Cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide viable counting assays. cycle pattern observed by...