A5004378997- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Brain Metastases and Treatment
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Genetic Syndromes and Imprinting
- Melanoma and MAPK Pathways
- Caveolin-1 and cellular processes
- Lung Cancer Treatments and Mutations
- Metabolism, Diabetes, and Cancer
- Angiogenesis and VEGF in Cancer
- Natural product bioactivities and synthesis
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
Virginia Commonwealth University
2020-2023
The University of Texas MD Anderson Cancer Center
2011-2021
Tongji University
2011-2018
The University of Texas Health Science Center at Houston
2017
The First Affiliated Hospital, Sun Yat-sen University
2012-2016
Sun Yat-sen University
2012-2016
Ruijin Hospital
2014
Shanghai East Hospital
2014
Shanghai First People's Hospital
2011-2014
National Cancer Institute
2010-2013
Circular RNAs (circRNAs) are RNA transcripts that widespread in the eukaryotic genome. Recent evidence indicates circRNAs play important roles tissue development, gene regulation, and carcinogenesis. However, whether encode functional proteins remains elusive, although translation of several was recently reported. CircRNA deep sequencing performed by using 10 pathologically diagnosed glioblastoma samples their paired adjacent normal brain tissues. Northern blotting, Sanger sequencing,...
Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten compromise gains made systemic chemotherapy. The blood-tumor barrier (BTB) is compromised many brain metastases; however, the extent which this influences chemotherapeutic delivery efficacy unknown. Herein, we answer question by measuring BTB passive integrity, drug uptake, anticancer vivo two models that metastasize preferentially brain.Experimental metastasis uptake...
Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although translation circRNAs was reported, additional coding and functions their translated products remain elusive. Here, we demonstrate that an endogenous circRNA generated from long noncoding RNA encodes regulatory peptides. Through ribosome nascent-chain complex-bound sequencing (RNC-seq), discover several peptides potentially encoded by circRNAs. We identify 87-amino-acid peptide circular form intergenic...
Abstract Brain metastasis is a major cause of morbidity and mortality in patients with melanoma. The molecular changes that lead to brain remain poorly understood. In this study, we developed model study human melanoma found Stat3 activity was increased metastatic cells when compared cutaneous cells. expression activated also specimens the primary specimens. Increased activation by transfection constitutively enhanced metastasis, whereas blockade dominant-negative suppressed animal models....
Abstract Glioblastoma (GBM) is the most common type of adult malignant brain tumor, but its molecular mechanisms are not well understood. In addition, knowledge disease-associated expression and function YTHDF2 remains very limited. Here, we show that overexpression clinically correlates with poor glioma patient prognosis. EGFR constitutively activated in majority GBM causes through EGFR/SRC/ERK pathway. signaling phosphorylates serine39 threonine381, thereby stabilizes protein. required for...
The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role underlying mechanisms of FOXM1 metabolism are unknown. In this study, we characterized regulation aerobic glycolysis by its impact on pancreatic metabolism.The effect altered expression glycolytic enzymes tumor progression was examined using animal models cancer. Also, were analyzed vitro molecular biology. clinical relevance aberrant caused...
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability the blood-brain barrier. A comprehensive understanding underlying mechanism that allows cells to infiltrate is necessary circumvent treatment resistance BCBMs. Here, we determined expression a long noncoding RNA (lncRNA) named lncRNA associated with BCBM (Lnc-BM) prognostic progression metastasis in patients. In preclinical murine models, elevated...
Background: The expression level of several matrix metalloproteinases (MMPs), including MMP-2 and MMP-9, in ovarian cancer cells is directly associated with their invasive metastatic potentials. MMP-9 also expressed stromal adjacent to the tumor. To investigate contribution tumor growth, we examined angiogenesis progressive growth human implanted into mice without gene. Methods: Human SKOV3.ip1 HEY-A8 were peritoneal cavities nude that lacked gene for (MMP-9−/−) or wild type (MMP-9+/+) (10...
Abstract The transcription factor Forkhead box M1 (FoxM1) is overexpressed in malignant glioma. However, the functional importance of this human glioma not known. In present study, we found that FoxM1B was predominant FoxM1 isoform expressed but normal brain tissue. level protein expression tissues directly correlated with grade. glioblastoma inversely patient survival. Enforced caused SW1783 and Hs683 cells, which do form tumor xenografts, to regain tumorigenicity nude mouse model systems....
Abstract Krüppel-like factor 4 (KLF4) is highly expressed in epithelial tissues such as the gut and skin. However, role of KLF4 human gastric cancer development progression unknown. Here we show that protein expression was decreased or lost primary tumors and, particular, lymph node metastases when compared with normal mucosa. Moreover, loss significantly associated poor survival, also an independent prognostic marker a multivariate analysis. Consistently, most cell lines exhibited...
Abstract The mammalian forkhead box (Fox) transcription factor FoxM1b is implicated in tumorigenesis. However, the presence of expression and role gastric cancer remain unknown. Therefore, we investigated 86 cases primary 57 normal tissue specimens. We further underlying mechanisms altered effect this on growth metastasis using vitro animal models cancer. found weak protein mucous neck region mucosa, whereas observed strong staining for tumor cell nuclei various tumors lymph node metastases....