A5101520145- Cancer-related molecular mechanisms research
- Solid State Laser Technologies
- Photorefractive and Nonlinear Optics
- Advanced Fiber Laser Technologies
- RNA modifications and cancer
- RNA Research and Splicing
- Photonic and Optical Devices
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Effects of Environmental Stressors on Livestock
- Cancer, Stress, Anesthesia, and Immune Response
- PI3K/AKT/mTOR signaling in cancer
- Semiconductor Quantum Structures and Devices
- Cancer Mechanisms and Therapy
- Traditional Chinese Medicine Analysis
- Laser Design and Applications
- Photosynthetic Processes and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Medicinal Plant Pharmacodynamics Research
- Silicon Nanostructures and Photoluminescence
- Advanced Breast Cancer Therapies
Peking University Shenzhen Hospital
2025
The University of Texas MD Anderson Cancer Center
2014-2024
Renji Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
First Affiliated Hospital of GuangXi Medical University
2020-2024
Guangxi Medical University
2020-2024
Regend Therapeutics (China)
2023
Jilin Agricultural University
2021
Mudanjiang Medical University
2010-2018
Chaozhou Central Hospital
2013-2017
lncRNAs are known to regulate a number of different developmental and tumorigenic processes. Here, we report role for lncRNA BCAR4 in breast cancer metastasis that is mediated by chemokine-induced binding two transcription factors with extended regulatory consequences. SNIP1 PNUTS response CCL21 releases the SNIP1's inhibition p300-dependent histone acetylation, which turn enables BCAR4-recruited bind H3K18ac relieve RNA Pol II via activation PP1 phosphatase. This mechanism activates...
Abstract Nitric oxide (NO) is a key redox-active, small molecule involved in various aspects of plant growth and development. Here, we report the identification an NO accumulation mutant, nitric excess1 (noe1), rice (Oryza sativa), isolation corresponding gene, analysis its role NO-mediated leaf cell death. Map-based cloning revealed that NOE1 encoded catalase, OsCATC. Furthermore, noe1 resulted increase hydrogen peroxide (H2O2) leaves, which consequently promoted production via activation...
Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important roles in tumorigenesis. We systematically investigated the expression landscape and clinical relevance of snoRNAs >10,000 samples across 31 cancer types from The Cancer Genome Atlas. observed overall elevated their ribonucleoproteins multiple types. showed complex regulation snoRNA by host genes, copy number variation, DNA methylation. Unsupervised clustering revealed subtype is highly concordant with...
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability the blood-brain barrier. A comprehensive understanding underlying mechanism that allows cells to infiltrate is necessary circumvent treatment resistance BCBMs. Here, we determined expression a long noncoding RNA (lncRNA) named lncRNA associated with BCBM (Lnc-BM) prognostic progression metastasis in patients. In preclinical murine models, elevated...
Pre-harvest sprouting (PHS) or vivipary in cereals is an important agronomic trait that results significant economic loss. A considerable number of mutations cause PHS have been identified several species. However, relatively few viviparous mutants rice (Oryza sativa L.) reported. To explore the mechanism rice, we carried out extensive genetic screening and 12 (phs). Based on their phenotypes, these phs were classified into three groups. Here characterize detail one groups, which contains...
Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective (CTGF), interleukin 6 (IL-6), hyperglycemia-induced when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination...
RNA solution for a genetic problem Phenylketonuria provides classic case of the benefit newborn metabolic screening: It is single-gene disease that can be detected at birth, and its neurological effects prevented by dietary therapy. Unfortunately, this not always straightforward because disease-causing mutations in phenylalanine hydroxylase vary between patients affect severity phenotype, such some patients’ symptoms do fully respond to available interventions. Li et al . identified two long...
Photosynthesis is the final determinator for crop yield. To gain insight into genes controlling photosynthetic capacity, we selected from our large T-DNA mutant population a rice stunted growth with decreased carbon assimilate and yield production named photoassimilate defective1 (phd1). Molecular biochemical analyses revealed that PHD1 encodes novel chloroplast-localized UDP-glucose epimerase (UGE), which conserved in plant kingdom. The chloroplast localization of was confirmed by...
Abstract Long noncoding RNA (lncRNA) is yet to be linked cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA associated with cytosolic cyclin-dependent kinase CDK6 regulated CDK6-dependent phosphorylation fructose bisphosphatase PFK2 (PFKFB3) a cell-cycle–independent manner. In cells, these events promoted catalysis glucose 6-phosphate...
Selective CDK2 inhibitors have the potential to provide effective therapeutics for CDK2-dependent cancers and combating drug resistance due high cyclin E1 (CCNE1) expression intrinsically or CCNE1 amplification induced by treatment of CDK4/6 inhibitors. Generative models that take advantage deep learning are being increasingly integrated into early discovery hit identification lead optimization. Here we report a highly potent selective macrocyclic inhibitor QR-6401 (23) accelerated...
This study explores the mechanisms responsible for bandwidth reduction observed in Ge-on-Si photodetectors under high incident light power. We investigate impact of carrier-screening effect on through simulations, and we mitigate this by increasing applied bias voltage. The increase concentration photogenerated carriers leads to a carrier saturation drift velocity, which reduces photodetector; phenomenon is studied first time. determined primarily velocity when power below 2.5 mW, decrease...
This study explores the mechanisms responsible for bandwidth reduction observed in germanium photodetectors under high signal light power. We investigate impact of carrier-shielding effect on through simulations, and we mitigate this by increasing applied bias voltage. The increase concentration photogenerated carriers leads to a carrier saturation drift velocity, which reduces photodetector; phenomenon is studied first time. determined primarily velocity when incident power below 2.5 mW....
On May 15, 2021, China’s first Mars exploration mission, Tianwen-1 (TW-1), successfully landed its Zhurong rover in the southern Utopia Planitia on Mars. Pitted cones, a characteristic feature of both and landing area, play pivotal role understanding local geological processes. We conducted detailed investigation into spatial distribution, morphological characteristics, morphometric parameters these cones to uncover their origins. Using High-Resolution Imaging Camera images...
We report a laser architecture to obtain continuous-wave blue radiation at 488 nm. A 808 nm diodepumped the Nd:YVO4 crystal emitting 914 part of pump power was then absorbed by crystal. The remaining used Nd:YLF 1047 Intracavity sum-frequency mixing and realized in LBO reach radiation. obtained output 514 mW with diode 19.6 W
Abstract Background In highly intensive dairy farms, cows often suffer from metabolic disorders that cause severe oxidative stress. Objectives This study aimed to observe correlations and associations of stress‐related indicators with milk compositions metabolites. Methods Twenty‐two multiparous Holstein in early lactation were randomly selected a commercial farm. The morning was collected for composition metabolites analysis. Blood sampled via the tail vein analyze (reactive oxygen species,...
Abstract A precise forecast of the need for blood transfusions (BT) in patients undergoing total hip arthroplasty (THA) is a crucial step toward implementation precision medicine. To achieve this goal, we utilized supervised machine learning (SML) techniques to establish predictive model BT requirements THA patients. Additionally, employed unsupervised (UML) approaches identify clinical heterogeneity among these In study, recruited 224 THA. factors during perioperative period THA, LASSO...
Background Protectin D1 (PD1), derived from docosahexaenoic acid, has been shown to control and resolve inflammation in some experimental models of inflammatory disorders. We investigated the protective roles protectin pulmonary lung injury induced by lipopolysaccharide (LPS). Methods Mice were randomly assigned six groups ( n =6 per group): sham-vehicle group, sham-PD1 sham-zVAD-fmk LPS-vehicle LPS-PD1 LPS-PD1-zVAD-fmk group. injected intratracheally with 3 mg/kg LPS or saline, followed 24...
Fentanyl is a drug commonly used for perioperative and postoperative analgesia. Previous studies have confirmed that fentanyl can affect the progression of gastric cancer; however, this effect has not yet been elucidated. The purpose our study was thus to investigate role in cancer clarify its potential mechanisms.