A5003263192- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Neuroblastoma Research and Treatments
- Digestive system and related health
- Peripheral Artery Disease Management
- Growth Hormone and Insulin-like Growth Factors
- Ferroptosis and cancer prognosis
- Medicine and Dermatology Studies History
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Adrenal Hormones and Disorders
- Autoimmune and Inflammatory Disorders Research
Central European Institute of Technology – Masaryk University
2020-2024
Central European Institute of Technology
2020-2024
École pour l'informatique et les nouvelles technologies
2023
Rudjer Boskovic Institute
2012-2023
Lund University
2017-2023
The University of Texas MD Anderson Cancer Center
2014-2020
Masaryk University
2019
Cancer Genetics (United States)
2014
Texas State University
2014
Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles key cellular processes. N-BLR is a primate-specific long non-coding RNA modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion. We performed multivariate analyses of from two independent cohorts patients show abundance associated with tumor stage, invasion potential, overall patient survival. Through...
To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with pyknon motif), and to characterise potential as biomarker therapeutic target.FLANC expression was analysed in 349 tumours from four cohorts correlated clinical data. In series multiple vitro vivo models molecular analyses, we characterised fundamental biological roles this lncRNA. We further explored targeting FLANC mouse model colorectal cancer...
Altered folate levels may play an important role in colon carcinogenesis. The aim of this study was to investigate the association polymorphisms key folate-metabolizing genes with susceptibility sporadic cancer. Six common (two MTHFR and one each MTR, MTRR, RFC1, DHFR genes) were genotyped 300 healthy subjects cancer patients from Croatia. Obtained results indicate possible protective MTRR 66 AA (OR=0.655; 95% CI=0.441-0.973; p=0.04). Maximum-likelihood analysis haplotypes revealed a linkage...
Prostate cancer is one of the most common cancers in men, yet biology behind lethal disease progression and bone metastasis poorly understood. In this study, we found elevated levels microRNA-96 (miR-96) prostate samples. To determine molecular mechanisms by which miR-96 deregulation contributes to metastatic progression, performed an Argonaute2-immunoprecipitation assay, mRNAs associated with cell-cell interaction were enriched. The expression two cell adhesion molecules, E-Cadherin EpCAM,...
Heterogeneity of colorectal carcinoma (CRC) represents a major hurdle towards personalized medicine. Efforts based on whole tumor profiling demonstrated that the CRC molecular subtypes were associated with specific morphological patterns representing subregions. We hypothesize whole-tumor descriptors depend heterogeneity significant impact current predictors. investigated intra-tumor by morphology-guided transcriptomics to better understand links between gene expression and morphology...
Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms with not fully understood etiology. Interleukin 1β (IL1β) plays an important role in pancreatic pathology, especially carcinogenesis, but its pNET development remains unknown. The aim of this study was to analyze the association between IL1β polymorphisms and susceptibility pNETs. -511 C/T +3954 single-nucleotide (SNPs) were analyzed by real-time polymerase chain reaction-SNP analysis. serum values patients also determined....
Background: Tumor mutational burden (TMB) is an emerging genomic biomarker in cancer that has been associated with improved response to immune checkpoint inhibitors (ICIs) adult cancers. It was described variability TMB assessment introduced by different laboratory techniques and various settings of bioinformatic pipelines. In pediatric oncology, no study published describing this so far. Methods: our study, we performed whole exome sequencing (WES, both germline somatic) calculated 106...
Ultra-conserved genes or elements (UCGs/UCEs) in the human genome are extreme examples of conservation. We characterized natural variations 2884 UCEs and UCGs two distinct populations; Singaporean Chinese (n = 280) Italian 501) by using a pooled sample, targeted capture, sequencing approach. identify, with high confidence, these regions abundance rare SNVs (MAF<0.5%) which 75% is not present dbSNP137. association studies for complex traits can use this information to model expected...
Small extracellular vesicles (EVs) contain various signaling molecules, thus playing a crucial role in cell-to-cell communication and emerging as promising source of biomarkers. However, the lack standardized procedures impedes their translation to clinical practice. Thus, we compared different approaches for high-throughput analysis small EVs transcriptome.
High incidence of colon cancer worldwide indicates the importance studying genetic alterations that lead to its carcinogenesis. Two polymorphisms in H-ras gene, hexanucleotide tandem repeats first intron and SNP 81T>C exon, might be connected with susceptibility have been described. The aim our study was investigate these loci Croatian population determine if any them is population. hundred healthy volunteers 200 patients were genotyped using PCR RFLP methods. We noted statistically...