A5025085047- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Immune Response and Inflammation
- Mechanisms of cancer metastasis
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Digestive system and related health
- Molecular Biology Techniques and Applications
- Autoimmune and Inflammatory Disorders Research
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
Rudjer Boskovic Institute
2015-2025
Croatian Institute of Transfusion Medicine
2022
Croatian Academy of Sciences and Arts
2004
University of Zagreb
1997
University of Cincinnati
1994
To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with pyknon motif), and to characterise potential as biomarker therapeutic target.FLANC expression was analysed in 349 tumours from four cohorts correlated clinical data. In series multiple vitro vivo models molecular analyses, we characterised fundamental biological roles this lncRNA. We further explored targeting FLANC mouse model colorectal cancer...
Cytokines produced in the tumour microenvironment have an important role cancer pathogenesis. Altered cytokine expression may result increased susceptibility to and/or poor prognosis certain cancers. Therefore, aim of this study was investigate influence interleukin (IL)-8 and IL-10 on sporadic colon development progression. In our study, a statistically significant increase IL-8 messenger RNA (mRNA) decrease mRNA tissue compared with normal mucous observed ( P = 0.003; 1.3 × 10 −9 ). No...
Abstract Insulin‐like growth factor 2 (IGF 2) appears to be involved in the progression of many tumours. It binds at least two different types receptor: IGF type 1 1R) and mannose 6‐phosphate/IGF (M6‐P/IGF 2R). Ligand binding 1R provokes mitogenic anti‐apoptotic effects. M6‐P/IGF 2R has a tumour suppressor function—it mediates degradation. Mutation causes both diminished suppression augmented stimulation. The aim this study was investigate role its receptors 2R) human gastric cancer....
Background: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, analyze FHIT gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) radicular (RC). Methods: methods used were immunohistochemistry molecular genetic including loss heterozygosity (LOH) sequencing. Results: expression different among groups. Aberrant the highest KOT, then RC DC. LOH paraffin‐embedded specimens detected 22.6% 12.9% for respectively. Mutation...
Altered folate levels may play an important role in colon carcinogenesis. The aim of this study was to investigate the association polymorphisms key folate-metabolizing genes with susceptibility sporadic cancer. Six common (two MTHFR and one each MTR, MTRR, RFC1, DHFR genes) were genotyped 300 healthy subjects cancer patients from Croatia. Obtained results indicate possible protective MTRR 66 AA (OR=0.655; 95% CI=0.441-0.973; p=0.04). Maximum-likelihood analysis haplotypes revealed a linkage...
Pathophysiological processes associated with disturbances in cell and tissue oxidative homeostasis, are self-catalyzed process of lipid peroxidation. The end products peroxidation reactive aldehydes such as 4-hydroxy-2-nonenal (HNE), acting "second messengers free radicals." Although were first recognized only cytotoxic, new evidence has come to light, related their growth regulatory functions achieved through signaling. variable appearance HNE several organs indicates that its mode action...
Vascular endothelial growth factor (VEGF) is important mediator of angiogenesis, and its expression in colorectal tumors related to tumor progression. VEGF has been detected normal mucosa, primary colon cancers, metastatic tumors, patients with low have a better survival rate. In addition, anti-VEGF monoclonal antibody improves overall when used combination existing cancer therapy. Therefore, prediction production based on individual genetic background might be for predicting the course...
Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells their signal molecules can influence all progression, as well therapeutic intervention. cytokines known triggers growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we explored the immunohistochemical expression necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), IL-2, IL-6 tissues from 43 GEP-NEN patients with...
Background: The discovery that genetic alterations in oncogenes and tumour suppressor genes accompany formation many human tumours has encouraged the search for promote or suppress spread metastasis; nm23 is a promising candidate metastasis suppressing gene. Aims: To evaluate whether expression of nm23-H1 protein loss heterozygosity (LOH) gene associated with colon cancer progression. Materials/Methods: Paraffin wax embedded tissue sections were analysed immunohistochemically. DNA isolated...
Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms with not fully understood etiology. Interleukin 1β (IL1β) plays an important role in pancreatic pathology, especially carcinogenesis, but its pNET development remains unknown. The aim of this study was to analyze the association between IL1β polymorphisms and susceptibility pNETs. -511 C/T +3954 single-nucleotide (SNPs) were analyzed by real-time polymerase chain reaction-SNP analysis. serum values patients also determined....