A5048425075- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Cancer Research and Treatments
- Exercise and Physiological Responses
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
The University of Texas MD Anderson Cancer Center
2014-2023
TherapeuticsMD (United States)
2018
Texas A&M Health Science Center
2013
University of Puerto Rico, Medical Sciences Campus
2009
Abstract Obesity is associated with an increased risk of developing breast cancer and also worse clinical prognosis. The mechanistic link between obesity progression remains unclear, there has been no development specific treatments to improve the outcome obese patients. Here we show that obesity-associated NLRC4 inflammasome activation/ interleukin (IL)-1 signalling promotes progression. tumour microenvironment in context induces increase tumour-infiltrating myeloid cells activated turn...
Aurora B is a mitotic checkpoint kinase that plays pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. overexpressed many types of human cancers, which has made it an attractive target for cancer therapies. Tumor suppressor p53 genome guardian important negative regulator cycle. Whether are coordinately regulated during cycle not known. We report directly interacts with at different subcellular localizations phases (for instance,...
Purpose: The oncogenic miR-155 is upregulated in many human cancers, and its expression increased more aggressive therapy-resistant tumors, but the molecular mechanisms underlying miR-155-induced therapy resistance are not fully understood. main objectives of this study were to determine role chemotherapy evaluate anti-miR-155 treatment chemosensitize tumors.Experimental Design: We performed vitro studies on cell lines investigate resistance. To assess effects inhibition chemoresistance, we...
BackgroundObesity increases the risk of cancer death among postmenopausal women with estrogen receptor–positive (ER+) breast cancer, but direct evidence for mechanisms is lacking. The purpose this study to demonstrate mediating epidemiologic phenomenon.
To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with pyknon motif), and to characterise potential as biomarker therapeutic target.FLANC expression was analysed in 349 tumours from four cohorts correlated clinical data. In series multiple vitro vivo models molecular analyses, we characterised fundamental biological roles this lncRNA. We further explored targeting FLANC mouse model colorectal cancer...
Extensive reprogramming of cellular energy metabolism is a hallmark cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer and protects cells from tumorigenic transformation. opposes tumour-promoting programmes by enhancing c-Myc poly-ubiquitination subsequent degradation. demonstrates suppressive impact on glycolysis, glutaminolysis, mitochondrial biogenesis other major...
Previously we have reported that metastatic melanoma cell lines and tumor specimens reduced expression of ADAR1 consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects miRNAs editing on growth metastasis yet be determined. Here report miR-378a-3p is undergoing only the non-metastatic but not cells. function edited form different from its wild-type counterpart. preferentially binds 3'-UTR PARVA oncogene inhibits expression, thus preventing...
Zoledronic acid is being increasingly recognized for its antitumor properties, but the underlying functions are not well understood. In this study, we hypothesized that zoledronic inhibits ovarian cancer angiogenesis preventing Rac1 activation.The biologic effects of were examined using a series in vitro [cell invasion, cytokine production, activation, reverse-phase protein array, and vivo (orthotopic mouse models)] experiments.There was significant inhibition (HeyA8-MDR OVCAR-5) cell...
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to lack insight into deep mechanistic processes. In the past decade, deciphering functions small noncoding miRNAs in sepsis pathogenesis became dynamic research topic. To screen new miRNA targets therapeutics, we used samples array analysis PBMCs from patients with control individuals, blood 2 cohorts sepsis, multiple animal models: mouse cecum ligation...
Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to target this process are currently available. Here, an integrative computational analysis of the Cancer Genome Atlas OC data set and experimental validation identifies zinc finger transcription factor ZNF304 associated with metastasis. High tumoral expression poor overall survival in patients. Through reverse phase protein array analysis, we demonstrate that promotes multiple proto-oncogenic pathways important...
Breast cancer represents one of the most common forms in women worldwide, with an increase number newly diagnosed patients last decade. The role fatty acids, particularly a diet rich ω-3 and ω-6 polyunsaturated acids (PUFAs), breast development is not fully understood remains controversial due to their complex mechanism action. However, large animal models cell culture studies have demonstrated that high levels PUFAs inhibitory progression cancer, compared PUFAs. present review focused on...
Abstract Purpose Preclinical evidence suggests that natural killer cell (NK-cell) function and myokines facilitate the protective effects of exercise for breast cancer prevention. Since higher-intensity acutely promotes greater mobilization larger changes in NK-cell cytotoxicity than lower-intensity, high-intensity interval training (HIIT) might offer increased immune protection compared to moderate-intensity continuous-training (MICT). This study a 12-week HIIT program MICT usual care on...
Hyperglycemia during hyper-CVAD chemotherapy is associated with poor outcomes of acute lymphoblastic leukemia (ALL) (Cancer 2004; 100: 1179-85). The optimal clinical strategy to manage hyperglycemia unclear. To examine whether anti-diabetic pharmacotherapy can influence chemosensitivity ALL cells, we examined the impacts different agents on cell lines and patient samples. Pharmacologically achievable concentrations insulin, aspart glargine significantly increased number did so at lower than...
Abstract Once a patient is in septic shock, survival rates drop by 7.6% for every hour of delay antibiotic therapy. Biomarkers based on the molecular mechanism sepsis are important timely diagnosis and triage. Here, we study potential roles panel cellular viral miRNAs as biomarkers. We performed genome-wide microRNA (miRNA) expression profiling leukocytes from patients nonseptic controls, combined with quantitative RT-PCR plasmas two cohorts patients, surgical healthy volunteers....
The effects of AURKA overexpression associated with poor clinical outcomes have been attributed to increased cell cycle progression and the development genomic instability aneuploidy. We used RNA interference examine in human bladder cancer cells. Knockdown had minimal on proliferation but blocked tumor invasion. Whole genome mRNA expression profiling identified nicotinamide N-methyltransferase (NNMT) as a downstream target that was repressed by AURKA. Chromatin immunoprecipitation NNMT...
Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy. Hepatocyte growth factor (HGF) its receptor cMET augment cancer resistance chemotherapy, but their role in adrenocortical has not been examined. In this study, we investigated the association between HGF/cMET expression hallmarks of carcinoma. Transcriptomic immunohistochemical analyses indicated that increased human samples was positively associated cancer-related biologic processes,...
Abstract The regulation of microRNA (miRNA) biogenesis, function and degradation involves a range mechanisms, including interactions with RNA-binding proteins. potential contribution regulatory miRNAs to the expression these RNA interactor proteins that could control other is still unclear. Here we demonstrate circuit involving oncogenic tumor-suppressor an protein in chemotherapy-resistant ovarian cancer model. We identified characterized miR-15a-5p miR-25-3p as negative regulators hnRNPA1...
Fine particles were collected in three indoor environments and an outdoor reference site. Samples acid aqueous extracted for metal analyses cytokine expression study using a BEAS-2B line. Results revealed that the average PM2.5 concentration indoors was 5.8 μg/m3 while outside, it 9.4 μg/m3. The airborne concentrations air ranged from 0.01 ng/m3 (Cd) to 620 (Al). All metals analyzed higher when compared (I/O ratio) indicating contribution workplace. Some more efficiently (e.g., Ni, V, As)...
The pervasive role of microRNAs (miRNAs) in cancer pathobiology drives the introduction new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, meticulous screening strategies addressing specific tumor targets are needed. Small molecule inhibitors represent an attractive goal for these strategies. this study, we devised a strategy screen small that specifically inhibit, directly or indirectly, miR-10b (SMIRs) which is overexpressed metastatic tumors....