A5101473617- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Advanced NMR Techniques and Applications
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Climate change impacts on agriculture
- RNA modifications and cancer
- Cancer Research and Treatments
- ATP Synthase and ATPases Research
- Neurobiology and Insect Physiology Research
- Biochemical and Molecular Research
- Electron Spin Resonance Studies
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- Agricultural risk and resilience
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Connective Tissue Growth Factor Research
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Supercapacitor Materials and Fabrication
Advanced Institute of Convergence Technology
2022-2025
Kyung Hee University
2025
Chonnam National University Hwasun Hospital
2011-2025
Korea Basic Science Institute
2023-2024
Dankook University
2024
Seoul National University of Science and Technology
2021
The University of Texas MD Anderson Cancer Center
2014-2021
Chonnam National University Hospital
2007-2021
Gwangju Institute of Science and Technology
2009-2020
Sookmyung Women's University
2020
Tangent flow-driven ultrafiltration (TF-UF) is an efficient isolation process of milk exosomes without morphological deformation. However, the TF-UF approach with micro-ultrafiltration SiNx membrane filters suffers from clogging and fouling filter pores large bioparticles. Thus, it limited in long term, continuous quantities exosomes. In this work, we introduced electrophoretic oscillation (EPO) to remove pore by As a result, combined EPO-assisted TF (EPOTF) filtration can isolate bovine...
Extensive reprogramming of cellular energy metabolism is a hallmark cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer and protects cells from tumorigenic transformation. opposes tumour-promoting programmes by enhancing c-Myc poly-ubiquitination subsequent degradation. demonstrates suppressive impact on glycolysis, glutaminolysis, mitochondrial biogenesis other major...
To characterize the prevalence of hypoxia in leukemic bone marrow, its association with metabolic and transcriptional changes blasts utility hypoxia-activated prodrug TH-302 leukemia models.Hyperpolarized magnetic resonance spectroscopy was utilized to interrogate pyruvate metabolism marrow murine acute myeloid (AML) model. Nanostring technology used evaluate a gene set defining signature normal donors. The efficacy examined vitro vivo models.Metabolic imaging has demonstrated increased...
The new oncologic paradigm of precision medicine is focused on identifying metabolic, proteomic, transcriptomic and genomic variabilities in tumors that can be exploited to tailor treatments improve patient outcomes. Metabolic changes are a hallmark cancer, inhibition metabolic pathways now major strategy medicinal chemistry for targeting cancers. However, non-invasive biomarkers categorize subtypes short supply. purpose this study was characterize the intracellular extracellular profiles...
To identify ligands for orphan GPCRs, we searched novel neuropeptide genes in the Drosophila melanogaster genome. Here, describe CNMa, a cyclic that is highly potent and selective agonist GPCR, CG33696 (CNMaR). Phylogenetic analysis revealed arthropod species have two paralogous CNMaRs, but many taxa retain only one. CNMa potently activates CNMaR‐2 from Apis mellifera , suggesting both receptors are functional. Although conserved most arthropods, Lepidoptera lack gene. However, they CNMaR...
We present a joint experimental and computational study of the hexacyanoferrate aqueous complexes at equilibrium in 250 meV to 7.15 keV regime. The experiments computations include vibrational spectroscopy cyanide ligands, valence electronic absorption spectra, Fe 1s core hole spectra using element-specific-resonant X-ray emission techniques. Density functional theory-based quantum mechanics/molecular mechanics molecular dynamics simulations are performed generate explicit solute-solvent...
This study introduces a comprehensive approach to enhancing SiNx nanofilters for exosome isolation from bovine milk using the electrophoretic oscillation-assisted tangent-flow ultrafiltration (EPOTF) process. Reinforcing nanofilter with electro-spun poly(vinylidene fluoride) (PVDF) fibers significantly improved durability under high-pressure conditions, withstanding nearly 2.8 times greater pressures than nonreinforced nanofilters. The PVDF-fiber-coated achieved flow rate of over 70 mL...
Claudin 18.2 (CLDN18.2), a tight junction protein predominantly expressed in the normal gastric epithelium, has recently emerged as potential therapeutic target various solid tumors. Despite growing interest, comprehensive data on CLDN18.2 expression across primary tumors from different organs and their corresponding metastatic lesions remain limited. This study analyzed 102 patients with adenocarcinomas ovarian carcinomas 81 cases of mucinous using immunohistochemistry. We evaluated...
We report a combined chemoimmunotherapy vehicle consisting of plasmid loaded with doxorubicin and evaluate its efficacy in two different tumor models. A stable complex was formed 1300:1 ratio bound to native via intercalation. Pharmacokinetics the showed much slower clearance from plasma up 3 h compared 10 min for free doxorubicin. In mice bearing NCI-H358 xenografts, lower doses (doxorubicin 0.5 mg/kg, 4 mg/kg) effectively reduced growth high (5 (68% versus 77%). Similar results were...
Ionizing radiation (IR) cytotoxicity is primarily mediated through reactive oxygen species (ROS). Since tumor cells neutralize ROS by utilizing reducing equivalents, we hypothesized that measurements of potential using real-time hyperpolarized (HP) magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) can serve as a surrogate marker IR induced ROS. This hypothesis was tested in pre-clinical model anaplastic thyroid carcinoma (ATC), an aggressive head neck malignancy. Human...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that progresses without any symptom, and oftentimes, it detected at an advanced stage. The lack of prior symptoms effective treatments have created knowledge gap in the management this lethal disease. This issue can be addressed by developing novel noninvasive imaging-based biomarkers PDAC. We explored vivo hyperpolarized (HP) 13C MRS pyruvate to lactate conversion ex 1H NMR spectroscopy panel well-annotated patient-derived PDAC...
Survivin, a member of inhibitors apoptosis, has been found in various human cancers. Its expression is associated with tumor progression and adverse outcome. Angiogenesis an essential process for the primary to grow invade adjacent normal structures. Angiogenic factors such as vascular endothelial growth factor induce survivin cells. The current study was designed investigate possible role status angiogenesis gastric cancer.In this study, we conducted immunohistochemical investigation 106...
BackgroundsExpression of Livin, a member the inhibitors apoptosis protein family, is associated with tumor development and progression. The aims this study were to evaluate whether Livin affects oncogenic biological behavior colorectal cancer cells, document relationship between its expression various clinicopathological parameters in cancer. MethodsWe investigated impact on cell by using small interfering RNA pcDNA3.1 vector SW480 DKO1 lines. was RT-PCR immunohistochemistry coloretcal...
The cell-surface glycoprotein CD44 is closely associated with cell proliferation, tumor invasion, and metastasis. Previous studies have reported that knockdown of short hairpin RNA (shRNA) reduced proliferation migration, induced apoptosis. However, more efficient means delivering small interference are still necessary. We developed an in vitro model CD44-shRNA recombinant adenovirus (Ad-CD44-shRNA) evaluated its ability to alter apoptosis human colon cancer cells. An shRNA against was used...
Type II diabetes mellitus (DM2) is a significant risk factor for cancers, including breast cancer. However, proper diabetic cancer mouse model not well-established treatment strategy design. Additionally, the precise signaling pathways that regulate growth remain unresolved. In present study, we established suitable and demonstrated pathogenic role of on progression.We successfully generated transgenic human epidermal receptor 2 positive (Her2+ or ERBB2) with DM2 by crossing leptin mutant...
Abstract Global warming has been an issue lately in many aspects because it increasing trend since 1980s. Climate change might be a major concern to humanity affects economic sectors as well different of human life. Negative impacts climate on agricultural sector will especially dangerous agriculture is directly related food security and This paper analyzes the impact production 13 Asian countries from 1998 2007. study estimates country-level fixed effect (FE) panel model for using seasonal...
Purpose To assess in a mouse model whether early or late components of glucose metabolism, exemplified by fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and hyperpolarized carbon 13 (13C)-pyruvate magnetic resonance (MR) spectroscopy, can serve as indicators response ovarian cancer to multityrosine kinase inhibitor pazopanib. Materials Methods In this Animal Care Use Committee approved study, 17 days after the injection 2 × 106 human SKOV3 tumors cells into 14...
New low band gap copolymers <bold>P1–P4</bold>, based on thienylenevinylene (TV) and pyrrolo[3,2-<italic>d</italic>:4,5-<italic>d</italic>′]bisthiazole (PBTz).