A5100747079- Cancer-related gene regulation
- Pancreatic function and diabetes
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- Plant tissue culture and regeneration
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Osteoarthritis Treatment and Mechanisms
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Chronic Kidney Disease and Diabetes
- Food Quality and Safety Studies
- Phytochemistry and Biological Activities
- Tissue Engineering and Regenerative Medicine
- Endoplasmic Reticulum Stress and Disease
Gyeongnam Provincial Namhae College
2024-2025
Chonnam National University
2014-2024
Salk Institute for Biological Studies
2020-2024
Gyeongsang National University
2024
Incheon National University
2022
Green Cross (South Korea)
2014-2022
University of Michigan–Ann Arbor
2015-2020
Konyang University
2015-2017
Washtenaw Community College
2017
Daegu Gyeongbuk Institute of Science and Technology
2013-2016
Little research has been done to examine whether gamma-glutamyltransferase (GGT) is prospectively associated with the development of chronic kidney disease (CKD). We performed a prospective study association between GGT and risk for CKD.The cohort included total 10 337 healthy males normal baseline functions no proteinuria. Participants were workers in semiconductor manufacturing company its 13 affiliates. CKD was defined as either presence proteinuria or glomerular filtration rate (GFR) <...
Significance Opioid-induced respiratory depression (OIRD) is the direct cause of death from opioid overdose, which accounts for current global crisis. Here, we report that neurons expressing μ-opioid receptors in lateral parabrachial nucleus pontine group are necessary and sufficient pathogenesis OIRD. Activating these through endogenous or artificial G protein–coupled receptor signaling pathways rescues OIRD intact mice, suggesting its therapeutic utility patients.
Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, immediate avoidance. Yet little known about whether how multi-sensory cues are integrated conveyed each modality amygdala, a critical area perception learning. Here, we report neurons expressing calcitonin gene-related peptide (CGRP) in parvocellular...
Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. However, role of ChREBP diabetic nephropathy has not been elucidated. Thus, we investigated mesangial cells nephropathy. Treatment with 25 mM glucose (high glucose; HG) increased cellular O-GlcNAc and O-GlcNAcylated compared normal 5.5 glucose. O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate (PUGNAc), drug that increases O-GlcNAc,...
Citrus fruits are high in naringin, which has a beneficial effect on cardiovascular diseases. However, the matrix metalloproteinase-9 (MMP-9) regulation involved cell migration and invasion remains to be identified. Naringin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of MMP-9, under 10-25 microM concentration conditions vascular smooth muscle cells (VSMC). The TNF-alpha-induced VSMC were by naringin. Furthermore, naringin suppressed TNF-alpha-mediated release...
Several recent prospective studies have reported that obesity is associated with an increased risk for chronic kidney disease (CKD), but it unknown whether weight gain increases the CKD if one remains within "normal" category of body mass index (BMI). We prospectively followed a cohort 8792 healthy men who had no known factors and participated in comprehensive health evaluation program at large worksite. During 35,927 person-years follow-up, 427 new incident cases (estimated GFR <64 ml/min...
<i>Background/Aims:</i> Many patients with end-stage renal disease have additional comorbidities that are important to clinical study and impact the patient’s outcome. The Charlson Comorbidity Index (CCI) is a popular tool strong predictor of outcome in patients. We obtained comorbidity data from hospital discharge database using International Classification Disease, 10th revision (ICD-10) analyzed mortality rate incident undergoing maintenance hemodialysis (HD)....
Melatonin, a pineal gland hormone, has been suggested to treat postmenopausal osteoporosis due its inhibitory effect on osteoclast differentiation. We previously reported that protein arginine methyltransferase 1 (PRMT1) was an important mediator of receptor activator nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. However, the relationship between melatonin and PRMT1 in differentiation estrogen deficiency-induced is unclear. In this study, we investigated mechanisms vitro vivo...
We investigated the independent and combined effects of alcohol consumption, cigarette smoking metabolic syndrome on abnormal liver function, i.e., elevation serum enzyme levels. Participants a Korean population-based prospective cohort aged ≥30 years without disease, diabetes, or cardiovascular diseases were included. Information status, syndrome, defined as per criteria Adult Treatment Panel III, applied to evaluate their impact levels aspartate aminotransferase (AST), alanine (ALT),...
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is involved in the progression of diabetic retinopathy. Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has emerged as an important histone modification diverse diseases. Sirtuin (SIRT1) a deacetylase implicated onset metabolic Therefore, we examined roles type I PRMTs and their relationship with SIRT1 human RPE cells under H 2 O -induced oxidative stress. treatment increased PRMT1 PRMT4...
Carbamoyl phosphate synthetase-1 (CPS1) is the major mitochondrial urea cycle enzyme in hepatocytes. It released into mouse and human blood during acute liver injury, where has a short half-life. The function of CPS1 reason for its half-life serum are unknown. We show that normally bile, pathologically injury. Other cytoplasmic enzymes also found normal bile. Serum, purified manifest sedimentation properties overlap with extracellular vesicles, due to propensity aggregate despite being...
Significance Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol 3,4-bisphosphate [PI(3,4)P 2 ] 3,4,5-trisphosphate [PI(3,4,5)P 3 3-phosphatase that plays important roles in cell polarization, division, development as well tumor suppression. Voltage-sensing phosphatases (VSPs) are PTEN family members but have catalytic activity response to membrane depolarization with wider range of substrates: They cleave the 5-phosphate PI(3,4,5)P 4,5-bisphosphate 3-phosphate PI(3,4)P perhaps ....