A5054372269- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Digital Radiography and Breast Imaging
- Menopause: Health Impacts and Treatments
- Cardiac Imaging and Diagnostics
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Metabolism, Diabetes, and Cancer
- Sleep and related disorders
- Gastroesophageal reflux and treatments
- Global Cancer Incidence and Screening
- Thyroid Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Blood Pressure and Hypertension Studies
Kangbuk Samsung Hospital
2016-2025
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2016-2025
Samsung Medical Center
2003-2023
Osaka City General Hospital
2023
Osaka Prefectural Medical Center
2023
University of Oxford
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Background: The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. Objective: To investigate the incident CKD across categories of body mass index in a large cohort men and women. Design: Prospective study. Setting: Kangbuk Samsung Health Study, Hospital, Seoul, South Korea. Participants: 62 249 healthy, young middle-aged women or proteinuria at baseline. Measurements:...
There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated status composition of This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total 758 men were selected divided into three groups: never (n = 288), former 267), current smokers 203). Among groups, there no difference in alpha diversity, however, Jaccard-based beta diversity showed significant (p 0.015). Pairwise permutational...
The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and development NAFLD in large cohort men women.A study was conducted 77,425 women free abnormalities at baseline, who were followed-up annually or biennially for an average 4.5 years. Being defined not having...
Electronic health record (EHR)-based research allows the capture of large amounts data, which is necessary in NAFLD, where risk clinical liver outcomes generally low. The lack consensus on International Classification Diseases (ICD) codes should be used as exposures and limits comparability generalizability results across studies. We aimed to establish among a panel experts ICD that could become reference standard provide guidance around common methodological issues.Researchers with an...
Following the adoption of new nomenclature for steatotic liver disease, we aimed to build consensus on use International Classification Diseases codes and recommendations future research advocacy.
In nonalcoholic fatty liver disease (NAFLD), increased alanine aminotransferase (ALT) concentrations are considered to be a consequence of hepatocyte damage. We performed prospective study examine the association between ALT within its reference interval and risk for subsequent development NAFLD.The cohort comprised 5237 healthy men without diagnosed NAFLD increases either (> or =35 U/L) gamma-glutamyltransferase (GGT; > =40 above intervals. assessed alcohol intake via self-reporting...
Little research has been done to examine whether gamma-glutamyltransferase (GGT) is prospectively associated with the development of chronic kidney disease (CKD). We performed a prospective study association between GGT and risk for CKD.The cohort included total 10 337 healthy males normal baseline functions no proteinuria. Participants were workers in semiconductor manufacturing company its 13 affiliates. CKD was defined as either presence proteinuria or glomerular filtration rate (GFR) <...
Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins cause toxicological renal effects at high levels, but the relevance of low-level environmental exposures in general population is controversial. A total 1,797 adults who participated KNHANES (a cross-sectional nationally representative survey Korea) were examined, 128 them (7.1%) had chronic kidney disease (CKD). Our study assessed association between Pb, Hg, Cd exposure, CKD. Blood Pb levels correlated with CKD...
We hypothesized that nonalcoholic fatty liver disease (NAFLD) is independently associated with cognitive impairment in a representative sample of the general US population regardless presence cardiovascular (CVD) or its risk factors.This was cross-sectional study 4,472 adults aged 20-59 years who participated Third National Health and Nutritional Examination Survey. The participants underwent assessment enzyme activity hepatic steatosis by ultrasound, evaluation using following...
No study has evaluated an association between non-alcoholic fatty liver disease (NAFLD) severity and the incidence of diabetes. We examined whether NAFLD its severity-using fibrosis score (NFS)-predict development diabetes.A cross-sectional was performed in 43,166 apparently healthy Koreans aged 30-59 years, who underwent a health checkup 2005 2006. Of these, 38,291 subjects without diabetes were followed annually or biennially until December 2011 for cohort study. defined as hepatic...
Gut microbiota plays an important role in the harvesting, storage, and expenditure of energy obtained from one's diet. Our cross-sectional study aimed to identify differences gut according body mass index (BMI) a Korean population. 16S rRNA gene sequence data 1463 subjects were categorized by BMI into normal, overweight, obese groups. Fecal microbiotas compared determine diversity functional inference analysis related with BMI. The correlation between genus-level was tested using...
Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but prospective association between NAFLD and progression has not been evaluated. This study conducted to evaluate coronary atherosclerosis.This retrospective cohort included 4731 adult men women no history cardiovascular (CVD), or cancer at baseline who participated repeated regular health screening examination 2004...
Recent evidence suggests that alcoholic fatty liver disease (AFLD) and non-alcoholic (NAFLD) may differentially affect risk of cardiovascular mortality. To investigate whether early due to AFLD or NAFLD have similar dissimilar effects on coronary artery atherosclerosis, we investigated the associations between calcium (CAC).A cross-sectional study was performed in 105 328 Korean adults who attended a health check-up programme. CAC score assessed using CT, daily alcohol intake recorded as...
Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with cross-sectionally, but the longitudinal relation between changes in body uncharacterized. The study aim was to examine whether gains were related symptom reporting over time. Measures of bioelectrical impedance for fat, reproductive hormones, reported assessed annually 4 years from 2002 2006 among 1,659...
The effect of modest alcohol consumption on fibrosis progression in the general population with nonalcoholic fatty liver disease (NAFLD) remains unclear. We examined association nonheavy worsening noninvasive indices a large‐scale, low‐risk NAFLD. A cohort study was performed 58,927 Korean adults NAFLD and low scores who were followed for median 4.9 years. Non‐, light, moderate drinkers defined as 0 g/day, 1‐9.9 10‐29.9 g/day (10‐19.9 women), respectively. Progression from to intermediate or...
Objective In addition to the controversy regarding association of hyperuricemia with cardiovascular disease ( CVD ) mortality, few studies have examined impact a low uric acid level on mortality. We undertook present study evaluate relationship between both and high levels risk all‐cause cause‐specific mortality in large sample Korean adults over full range levels. Methods A cohort was performed 375,163 South men women who underwent health check‐ups from 2002 2012. Vital status cause death...
The presence of an association between chronic hepatitis B virus (HBV) infection and fatty liver is controversial. We examined the HBV development nonalcoholic disease (NAFLD). conducted a cohort study 83,339 participants without NAFLD at baseline who underwent serologic testing for surface antigen (HBsAg) 2002 2006 were followed annually or biennially until December 2014. was defined as ultrasonographic in absence excessive alcohol use other identifiable causes. used parametric Cox model to...
OBJECTIVES: The role of smoking in the development non-alcoholic fatty liver disease (NAFLD) remains controversial. We assessed risk incident NAFLD according to status and urinary cotinine levels. METHODS: performed a cohort study 199,468 Korean adults without at baseline who were followed annually or biennially for median 4.1 years. presence was determined using ultrasound. severity fibrosis score (NFS), non-invasive marker. RESULTS: During 1,070,991 person-years follow-up, 45,409...
Abstract Although obesity is associated with numerous diseases, the risks of disease may depend on metabolic health. Associations between gut microbiota, obesity, and syndrome have been reported, but differences in microbiomes according to health obese population not explored previous studies. Here, we investigated composition microbiota status overweight subjects. A total 747 or adults were categorized by status, their fecal profiled using 16S ribosomal RNA gene sequencing. We classified...