A5010379448- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Bone health and treatments
- Menopause: Health Impacts and Treatments
- Hip and Femur Fractures
- Cancer Risks and Factors
- Vitamin D Research Studies
- Phytoestrogen effects and research
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Genetic Associations and Epidemiology
- Global Cancer Incidence and Screening
- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- Hip disorders and treatments
- Nutrition, Genetics, and Disease
- Sex and Gender in Healthcare
- Bone fractures and treatments
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal and reproductive studies
- Nutritional Studies and Diet
- MXene and MAX Phase Materials
- Parathyroid Disorders and Treatments
University of California, Los Angeles
2016-2025
University of Pittsburgh
2007-2024
University of Massachusetts Boston
2020-2023
American Society for Bone and Mineral Research
2020-2023
Zero to Three
2020-2023
John Wiley & Sons (United States)
2020-2023
Faculty of Media
2019-2022
UCLA Health
2000-2022
Palo Alto Networks (United States)
2022
Columbia University
2007-2022
"The 2022 Hormone Therapy Position Statement of The North American Menopause Society" (NAMS) updates 2017 and identifies future research needs. An Advisory Panel clinicians researchers expert in the field women's health menopause was recruited by NAMS to review Statement, evaluate new literature, assess evidence, reach consensus on recommendations, using level evidence identify strength recommendations quality evidence. Panel's were reviewed approved Board Trustees.Hormone therapy remains...
Early age at the natural final menstrual period (FMP) or menopause has been associated with numerous health outcomes and might be a marker of future ill health. However, potentially modifiable factors affecting have not examined longitudinally in large, diverse populations. The Study Women's Health Across Nation (SWAN) followed 3,302 initially premenopausal early perimenopausal women from 7 US sites 5 racial/ethnic groups, using annual data (1996–2007) Cox proportional hazards models to...
Background and Objective: To determine whether patterns of change in serum estradiol (E2) FSH across the menopausal transition were associated with age at final menstrual period (FMP). Design Setting: The Study Women's Health Across Nation (SWAN) is a seven-site, multiethnic, longitudinal study being conducted 3302 menstruating women who aged 42–52 yr 1996 baseline. Measurements: Annually collected was assayed for E2 levels. Patterns hormone evaluated 1215 documented natural FMP by follow-up...
Abstract The objective of this study was to describe the time onset and offset bone mineral density (BMD) loss relative date final menstrual period (FMP); rate amount BMD decline during 5 years before after FMP; independent associations between age at FMP, body mass index (BMI), race/ethnicity with rates interval. sample included 242 African American, 384 white, 117 Chinese, 119 Japanese women, pre- or early perimenopausal baseline, who had experienced their FMP for whom an could be...
To determine the association between use of vaginal estrogen and risk a global index event (GIE), defined as time to first occurrence coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal endometrial or death from any cause.
ABSTRACT Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches patient care and discrepancies among treatment guidelines. To help bridge this gap improve outcomes, the American Society for Bone Mineral Research assembled a multistakeholder coalition develop clinical recommendations optimal prevention of secondary fracture people aged 65 years older with hip or vertebral fracture. The developed 13 (7 primary 6 secondary) strongly supported...
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X analyze genotypes with quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density triglycerides. Common variant association yields known loci except few variants previously poorly imputed. Rare coding Mendelian dyslipidemia genes but rare...
Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. Evidence-based screening strategies improve identification of patients who are most likely to benefit from drug treatment prevent fracture. In addition, careful consideration when pharmacotherapy should be started, choice medication, duration maximizes the benefits prevention while minimizing potential harms long-term exposure.
Importance Approximately 55 million people in the US and approximately 1.1 billion worldwide are postmenopausal women. To inform clinical practice about health effects of menopausal hormone therapy, calcium plus vitamin D supplementation, a low-fat dietary pattern, Women’s Health Initiative (WHI) enrolled 161 808 women (N = 68 132 trials) aged 50 to 79 years at baseline from 1993 1998, followed them up for 20 years. Observations The WHI trial results do not support therapy with oral...
The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments type 2 diabetes. This is based the best available evidence for effectiveness, comparative benefits and harms, consideration patients' values preferences, costs.
Most menopausal women report vasomotor symptoms (hot flashes, night sweats). However, not all with symptoms, including frequent are bothered by them. The primary aim was to identify correlates of symptom bother beyond frequency.The Study Women's Health Across the Nation participants reporting at annual visit 7 comprised sample (N = 1,042). Assessments included hot flash and sweats frequency (number per week) (1, all- 4, very much). Negative affect (index depressive anxiety, perceived stress,...
Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with cross-sectionally, but the longitudinal relation between changes in body uncharacterized. The study aim was to examine whether gains were related symptom reporting over time. Measures of bioelectrical impedance for fat, reproductive hormones, reported assessed annually 4 years from 2002 2006 among 1,659...
Emerging research suggests links between menopausal hot flashes and cardiovascular disease risk. The mechanisms underlying these associations are unclear, due to the incomplete understanding of physiology flashes. OBJECTIVE AND MAIN OUTCOME MEASURES: We examined flashes/night sweats glucose insulin resistance over 8 yr, controlling for risk factors reproductive hormones.Participants in Study Women's Health Across Nation (SWAN) (n=3075), a longitudinal cohort study, were ages 42-52 yr at...
Considerable efforts have been undertaken to relate single nutrients bone health. To this point, results are inconsistent. Suboptimal nutrient intake does not occur in isolation but rather reflects a poor diet quality.
ABSTRACT Although several studies have noted increased fracture risk in individuals with type 2 diabetes mellitus (T2DM), the pathophysiologic mechanisms underlying this association are not known. We hypothesize that insulin resistance (the key pathology T2DM) negatively influences bone remodeling and leads to reduced strength. Data for study came from 717 participants Biomarker Project of Midlife United States Study (MIDUS II). The homeostasis model assessment (HOMA-IR) was calculated...
To better understand how to educate patients and providers about study findings relevant treatment guidelines, we assessed pre- versus post-Women's Health Initiative (WHI) differences in menopausal hormone therapy (MHT) initiation continuation their correlates, women's reasons for discontinuation.We analyzed survey data from up 14 approximately annual visits over 17 years (1996-2013) 3,018 participants the Study of Women's Across Nation, a prospective cohort study. We used logistic...