Tonya Orchard

ORCID: 0000-0002-7265-7314
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About
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Research Areas
  • Cancer-related cognitive impairment studies
  • Nutritional Studies and Diet
  • Fatty Acid Research and Health
  • Cancer, Stress, Anesthesia, and Immune Response
  • Diet and metabolism studies
  • Bone health and osteoporosis research
  • Nutrition and Health in Aging
  • Cancer, Lipids, and Metabolism
  • Cancer survivorship and care
  • Adipokines, Inflammation, and Metabolic Diseases
  • Tryptophan and brain disorders
  • Air Quality and Health Impacts
  • Cancer Risks and Factors
  • Inflammatory mediators and NSAID effects
  • Estrogen and related hormone effects
  • Diet, Metabolism, and Disease
  • Adipose Tissue and Metabolism
  • Climate Change and Health Impacts
  • Metabolism, Diabetes, and Cancer
  • Cancer Treatment and Pharmacology
  • Neurogenesis and neuroplasticity mechanisms
  • Frailty in Older Adults
  • Parathyroid Disorders and Treatments
  • Family Support in Illness
  • Therapeutic Uses of Natural Elements

The Ohio State University
2016-2025

Wake Forest University
2020

University of North Carolina at Chapel Hill
2020

University of Washington
2020

Columbia University
2020

Indiana University Bloomington
2020

University of Southern California
2020

University of South Dakota
2020

May Institute
2019

Women's Health Initiative
2015

Considerable efforts have been undertaken to relate single nutrients bone health. To this point, results are inconsistent. Suboptimal nutrient intake does not occur in isolation but rather reflects a poor diet quality.

10.1001/jamainternmed.2016.0482 article EN JAMA Internal Medicine 2016-03-28

Obesity is a strong risk factor for nephrolithiasis, but the role of physical activity and caloric intake remains poorly understood. We evaluated this relationship in 84,225 women with no history stones as part Women’s Health Initiative Observational Study, longitudinal, prospective cohort postmenopausal enrolled from 1993 to 1998 8 years’ median follow-up. The independent association (metabolic equivalents [METs]/wk), calibrated dietary energy intake, body mass index (BMI) incident kidney...

10.1681/asn.2013050548 article EN Journal of the American Society of Nephrology 2013-12-13

ABSTRACT Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association dietary index (DII), a measure potential diet, hip, lower-arm, total using longitudinal data from Women's Health Initiative Observational Study Clinical Trials. Secondarily, we evaluated changes in mineral density (BMD) DII scores. scores were calculated baseline food frequency...

10.1002/jbmr.3070 article EN Journal of Bone and Mineral Research 2016-12-26

Abstract Background In the Women’s Health Initiative (WHI) randomized trial, dietary intervention significantly reduced breast cancer mortality, especially in women with more metabolic syndrome (MetS) components. Therefore, this study investigated associations of MetS and obesity postmenopausal after long‐term follow‐up WHI clinical trials. Methods A total 68,132 women, without prior normal mammogram, were entered into trials; 63,330 an entry score comprised population. At entry, body mass...

10.1002/cncr.35318 article EN Cancer 2024-05-13

Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) in red blood cells (RBCs) are an objective indicator of PUFA status may be related to hip fracture risk. The primary this study was examine RBC PUFAs as predictors risk postmenopausal women. A nested case-control (n = 400 pairs) completed within the Women's Health Initiative (WHI) using 201 incident cases from Bone Mineral Density (BMD) cohort, along with 199 additional randomly selected WHI Observational Study....

10.1002/jbmr.1772 article EN Journal of Bone and Mineral Research 2012-09-27

Background: Previous studies suggest that certain dietary patterns and constituents may be beneficial to brain health. Airborne exposures fine particulate matter [particulate with aerodynamic diameter ≤2.5μm (PM2.5)] are neurotoxic, but the combined effects of PM2.5 have not been investigated. Objectives: We examined whether previously reported association between exposure lower white volume (WMV) differed women whose usual diet during last 3 months before baseline was more or less...

10.1289/ehp8036 article EN public-domain Environmental Health Perspectives 2021-12-01

One in two individuals with spinal cord injury (SCI) experiences postprandial hypotension (PPH), a decline (>20 mm Hg) systolic blood pressure (SBP) within 2 hours after eating. Consuming meals low glycemic index (GI) could prevent or lessen PPH. To determine the effect of low-GI diet on PPH and glucose insulin chronic SCI (>1 year postinjury). Eleven participants (6 males, 5 females; age 43 ± 11 years) (C4-C7, 7; T4-T12, 4) took part randomized crossover study (low GI vs. high GI). On each...

10.46292/sci24-00044 article EN Topics in Spinal Cord Injury Rehabilitation 2025-02-01

The Mediterranean diet has been linked to preserving physical function, but studies on its impact function decline in older adults have shown mixed results. This longitudinal study used a large sample of community-dwelling women from the Women's Health Initiative Long Life Study examine this relationship. We assessed 4516 (mean age at baseline = 78.97), including subsample 849 who reported currently having diabetes. Data measured by SF-36 Physical Function subscale, were collected annually...

10.1080/21551197.2025.2484528 article EN Journal of Nutrition in Gerontology and Geriatrics 2025-04-03

To examine whether long-chain omega-3 polyunsaturated fatty acid (LCn3PUFA) levels modify the potential neurotoxic effects of particle matter with diameters <2.5 µm (PM2.5) exposure on normal-appearing brain volumes among dementia-free elderly women.A total 1,315 women (age 65-80 years) free dementia were enrolled in an observational study between 1996 and 1999 underwent structural MRI 2005 to 2006. According prospectively collected geocoded participant addresses, we used a spatiotemporal...

10.1212/wnl.0000000000010074 article EN Neurology 2020-07-16

Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with U.S. pediatric prevalence of 8–10%. It presents inattention and hyperactivity/impulsivity; frequently associated emotional dysregulation (ED) symptoms common in Oppositional Defiant Disruptive Mood Dysregulation Disorder. The etiology ADHD multi-factorial; symptom severity diet. This study examines the association diet quality ED within research cohort.Methods: Baseline data were analyzed for...

10.1080/1028415x.2022.2071805 article EN cc-by-nc-nd Nutritional Neuroscience 2022-05-10

Chronic inflammation may increase the risk of fracture, and omega-3 polyunsaturated fatty acids (PUFAs) reduce fracture via down-regulation inflammatory cytokine gene expression other mechanisms.We investigated associations between baseline samples markers, TNFα soluble receptors 1 2 (TNFα-sR1 -sR2), incident hip fracture. These were then tested for effect modification by dietary PUFA intake estimated a food frequency questionnaire.A nested case-control study was conducted among participants...

10.1210/jc.2015-1662 article EN The Journal of Clinical Endocrinology & Metabolism 2015-07-10

Cancer-related cognitive impairment (CRCI) is one of the most prevalent symptoms that breast cancer survivors experience. While treatments are established contributors to CRCI, inter-individual differences in CRCI not well understood. Individual sensitivity uncertainty potential CRCI; however, no prior studies have attempted examine this link context cancer. To address gap, we used preliminary findings from an ongoing cross-sectional study. A total 38 women with stage I-III (1-4 years...

10.3390/cancers15123105 article EN Cancers 2023-06-08
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