A5025426780- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Vitamin C and Antioxidants Research
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Free Radicals and Antioxidants
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tryptophan and brain disorders
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Hemoglobin structure and function
- Cardiovascular and exercise physiology
- Natural Compound Pharmacology Studies
- Bipolar Disorder and Treatment
- Child Nutrition and Water Access
- Nutrition, Genetics, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and biosynthesis
The Ohio State University
2014-2024
Zero to Three
2013
Expression Therapeutics (United States)
2010
Brigham and Women's Hospital
1999-2008
Harvard University
1999-2008
Harvard University Press
2007
University of Southern California
1998-2006
University of Pennsylvania
2003-2006
Cardiovascular Research Center
2004
University of Graz
1995-2003
Increased levels of triglyceride-rich lipoproteins provoke lipid accumulation in the artery wall, triggering early inflammatory responses central to atherosclerosis like endothelial adhesion molecule expression. The endogenous mechanisms limiting such reactions remain poorly defined. Lipoprotein lipase (LPL) plays a role metabolism by hydrolyzing triglyceride rich and releasing fatty acids. We found that LPL treatment reversed tumor necrosis factor alpha very low-density lipoprotein...
Millet varieties were analyzed for nutritional, antinutritional, mineral and phenolic profiles. Inhibition potential of acids enzyme inhibition activity was estimated, alongside starch digestibility millet grains evaluated. Finger found to have high contents Ca, Fe, Zn, Mn Cu minerals. Proso pearl had protein content, whereas kodo foxtail contained more dietary fiber. Phytic acid comparatively higher in millet, oxalic total tannin content abundant finger millet. Total flavonoid bound...
beta-Carotene and its metabolites exert a broad range of effects, in part by regulating transcriptional responses through specific nuclear receptor activation. Symmetric cleavage beta-carotene can yield 9-cis retinoic acid (9-cisRA), the natural ligand for RXR, obligate heterodimeric partner numerous family members. A significant portion also undergo asymmetric to apocarotenals, series poorly understood naturally occurring molecules whose biologic role, including their remains essentially...
Vitamin A metabolite retinoic acid (RA) regulates life-sustaining differentiation processes and metabolic homeostasis. The aldehyde dehydrogenase-1 (Aldh1) family of enzymes (Aldh1a1, a2, a3) catalyzes RA production from retinaldehyde thereby controls concentrations this transcriptionally active metabolite. hierarchy Aldh1 functions in adipose tissue has not been elucidated. We hypothesized that produce endogenous regulate adipogenesis fat formation a depot-specific manner. demonstrate vitro...
Functional assessments of cardiovascular fitness (CVF) are needed to establish animal models dysfunction, test the effects novel therapeutics, and cardio-metabolic phenotype mice. In humans, graded maximal exercise (GXT) is a standardized diagnostic for assessing CVF mortality risk. These tests, which consist concurrent staged increases in running speed inclination, provide parameters, such as, VO2max, anaerobic threshold, metabolic crossover. Unlike human-GXT, published mouse treadmill...
Human blood contains a form of minimally modified low density lipoprotein (LDL), termed LDL−, whose origin remains unknown. Exploring the mechanism formation, we found that LDL− can be produced in plasma absence oxygen following LDL incubation with oxidized hemoglobin species. A high degree apolipoprotein B100 modification results from covalent association involving dityrosine formation but not due to malonaldehyde epitope formation. This was evidenced by cross-reactivity antibodies against...
Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, -a3), major RA-producing enzymes, on sex-specific depot formation. Female Aldh1a1(-/-) mice, but not males, were resistant to high-fat (HF) diet-induced visceral adipose formation, whereas subcutaneous was reduced similarly in both groups. Sexual dimorphism (VF) attributable elevated triglyceride lipase (Atgl) protein...
Although high-density lipoprotein (HDL) is known to inhibit endothelial adhesion molecule expression, the mechanism for this anti-inflammatory effect remains obscure. Surprisingly, we observed that HDL no longer decreased of U937 monocytoid cells tumor necrosis factor (TNF)alpha-stimulated human (EC) in presence general lipase inhibitor tetrahydrolipstatin. In considering mechanisms responsible effect, found (EL) overexpression both EC and non-EL-expressing NIH/3T3 mouse embryonic...
In 59 healthy human subjects (37 male and 22 female) the concentrations of lipid-soluble antioxidants alpha- gamma-tocopherol, beta-carotene, lycopene, cryptoxanthin, canthaxanthin, lutein + zeaxanthin were determined in plasma (mumol/L) isolated low density lipoproteins (LDL) (mumol/mmol cholesterol). Plasma alpha-tocopherol significantly correlated with total cholesterol (r2 = 0.51, P < 0.0001) yet not LDL content 0.05, ns). gamma-tocopherol weakly 0.12, 0.003) both absolute standardized...
Abstract Genetic, dietary, and inflammatory factors contribute to the etiology of major mood disorders (MMD), thus impeding identification specific biomarkers assist in diagnosis treatment. We tested association vitamin D markers 36 adolescents with bipolar disorder (BD) depressive (MDD) forms MMD without (non-mood control). also assessed overall level inflammation using a cell-based reporter assay for nuclear factor kappa-B (NFκB) activation measuring antibodies oxidized LDL. found that...
Abstract Oxidation resistance (OR) of low density lipoproteins (LDL) is frequently determined by the conjugated diene (CD) assay, in which isolated LDL exposed to Cu 2+ as prooxidant range 1–10 μM. A brief review on major findings obtained with this assay will be given. consistent observation that vitamin E supplements or oleic acid‐rich diets increase OR. indices measured CD and effects antioxidants very significantly depend concentration used for oxidation. For medium high concentrations,...