A5059460857- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Cardiovascular Disease and Adiposity
- Cancer Mechanisms and Therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Genetic and Kidney Cyst Diseases
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
GTx (United States)
2021
Samsung (South Korea)
2018
Columbia University
2009-2016
Johns Hopkins University
2016
Creative Commons
2016
October 6 University
2016
Inje University
2013
Inje University Sanggye Paik Hospital
2009-2013
Increased translocation of intestinal bacteria is a hallmark chronic liver disease and contributes to hepatic inflammation fibrosis. Here we tested the hypothesis that microbiota Toll-like receptors (TLRs) promote hepatocellular carcinoma (HCC), long-term consequence injury, inflammation, Hepatocarcinogenesis in chronically injured livers depended on TLR4 activation non-bone-marrow-derived resident cells. were not required for HCC initiation but promotion, mediating increased proliferation,...
The current recommendation of ribavirin dose for the treatment chronic hepatitis C is based on study results Western patients, and might not be optimal Korean patients because different body frames.A total 163 treatment-naive genotype 1 who received combination therapy with pegylated interferon a-2a were reviewed.Under dosing, only 49% started 13-15mg/kg (targeted dose), while 45% 6% =16mg/kg <13mg/kg, respectively. Patients higher experienced more modification during (55%, 31% 11% =16mg/kg,...
Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, underlying mechanisms remain largely elusive. Moreover, not known whether other mononuclear phagocytes such as dendritic cells (DCs) contribute to stellate cell (HSC) activation and fibrosis. We show for first time enhance myofibroblast survival nuclear factor kappa B (NF-κB)-dependent manner thereby promote Microarray pathway analysis revealed no induction HSC pathways by but...
No adjuvant therapy has been shown to extend the survival of patients with hepatocellular carcinoma (HCC) receiving curative treatment. We investigated whether injections activated cytokine-induced killer (CIK) cells (CD3+/CD56+ and CD3+/CD56- T CD3-/CD56+ natural cells) prolongs recurrence-free after for HCC.We performed a multicenter, randomized, open-label, phase 3 trial efficacy safety immunotherapy CIK (created by incubation patients' peripheral blood mononuclear interleukin 2 an...
Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs in proinflammatory environment. However, the role of inflammatory mediators fibrogenic responses is only poorly understood. We therefore investigated CC chemokines their receptors hepatic fibrogenesis. The MIP-1alpha, MIP-1beta, RANTES CCR1 CCR5 were strongly upregulated 2 experimental mouse models Neutralization by broad-spectrum chemokine inhibitor 35k efficiently reduced fibrosis, CCR1-...
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of following cell death, but the relative contribution specific DAMPs, including high-mobility group box 1 (HMGB1), is ill defined. Due postnatal lethality Hmgb1-knockout mice, role HMGB1 in and disease processes vivo remains controversial. Here, using conditional ablation strategies, we have...
The long‐term clinical impact of low‐level viremia (LLV; <2,000 IU/mL) is not well understood. As a result, it unclear whether the development LLV during entecavir monotherapy requires change in therapy. A retrospective cohort 875 treatment‐naive chronic hepatitis B virus (HBV) monoinfected patients (mean age 47.7 years, male = 564 [65.5%], cirrhosis 443 [50.6%]) who received were analyzed for hepatocellular carcinoma (HCC). HCC risk was compared between maintained virological response...
Abstract Background A limited number of studies have characterized genomic properties hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods Herein, we performed comprehensive molecular characterization immediate (D-42 D-1) pre-treatment tumor biopsy specimens from 60 with sorafenib-failed HCC a single-arm prospective phase II trial pembrolizumab. Objective rate was the primary efficacy endpoint. We used whole-exome sequencing, RNA and correlative analysis....
<h3>Background</h3> It is generally stated that oral antiviral therapy in patients with chronic hepatitis B (CHB) decreases the risk of developing hepatocellular carcinoma (HCC). Although nucleos(t)ide analogues (NUCs) may induce a state similar to inactive stage CHB, long-term for HCC treated NUCs compared CHB unclear. <h3>Methods</h3> A total 1378 who were treatment naïve and started NUC 1014 HBeAg-negative continuously had DNA <2000 IU/mL during follow-up enrolled. The group was...
Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but prospective association between NAFLD and progression has not been evaluated. This study conducted to evaluate coronary atherosclerosis.This retrospective cohort included 4731 adult men women no history cardiovascular (CVD), or cancer at baseline who participated repeated regular health screening examination 2004...
To evaluate the frequency, risk factors, and clinical significance of aggressive intrasegmental recurrence (AIR) found after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC).Institutional review board approval was obtained this retrospective study. Between March 2005 December 2010, 539 patients (414 men, 125 women; mean age, 57.91 years; age range, 30-82 years) underwent ultrasonography-guided percutaneous RF as a first-line treatment single HCC classified Barcelona Clinic...
Controversy exists about whether antiviral therapy (AVT) should be recommended for compensated cirrhosis patients with chronic hepatitis B virus (HBV) infection and detectable, but low, serum HBV‐DNA levels. A retrospective cohort of 385 treatment‐naïve, HBV‐related (mean age: 51.1 ± 9.7 years; 66% male) low levels (<2,000 IU/mL) was assessed the development hepatocellular carcinoma (HCC). During a median 5.6 years follow‐up, HCC had developed in 37 (9.6%) patients. The 5‐year cumulative...
OBJECTIVES: We assessed the association among ultrasonographically detected non-alcoholic fatty liver disease (US-NAFLD), metabolic syndrome (MetS), and insulin resistance (IR) in non-obese, non-diabetic middle-aged adults, to find out whether US-NAFLD is independently associated with IR this population. METHODS: A total of 5,878 non-obese (body mass index, ≥18.5 <25), individuals were analyzed. was estimated homeostasis model assessment index (HOMA2–IR) defined when HOMA2–IR ≥1.5. MetS by...
<h3>Objective</h3> Hepatic stellate cells (HSCs) contain a number of bioactive metabolites or their precursors including retinoids in characteristic lipid droplets. The loss droplets and is hallmark HSC activation, but it remains unclear whether this promotes liver fibrogenesis carcinogenesis. <h3>Design</h3> Spontaneous experimental as well diethylnitrosamine-induced hepatocarcinogenesis were investigated lecithin-retinol acyltransferase (LRAT)-deficient mice which lack retinoid-containing...
Summary Background The risk of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor (PPI) use has been raised in cirrhotic patients ascites. However, this is based on case–control studies, often a small series. Aim To determine whether PPI increases the SBP using large cohort. Methods This retrospective cohort study included 1965 ascites diagnosed between January 2005 and December 2009. incidence rate was compared non‐PPI groups before after propensity score matching...
Non-alcoholic fatty liver disease (NAFLD) is a multisystem associated with an increased risk of cardiovascular (CVD), diabetes, and chronic kidney disease. Indeed, CVD the most common cause death in NAFLD patients. This study aimed to evaluate association between incident myocardial infarction.This retrospective cohort involving 111 492 adults over 40 years old without history CVD, disease, or cancer at baseline who participated regular health screening exam 2003 2013. Fatty was diagnosed by...
Abstract This study aimed to investigate the association of nonalcoholic fatty liver disease (NAFLD) and its severity with decline in kidney function patients chronic (CKD). We conducted a cohort 1,525 CKD who underwent repeated health check-up examinations from January 2003 through December 2013. NAFLD was diagnosed by ultrasonography assessed fibrosis score. At baseline, prevalence 40.9%, mean estimated glomerular filtration rate (eGFR) 59.1 ml/min/1.73 m 2 . The average follow-up 6.5...