A5037443946- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Liver physiology and pathology
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
- Veterinary medicine and infectious diseases
- Esophageal and GI Pathology
- HIV/AIDS drug development and treatment
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Pancreatitis Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Liver Diseases and Immunity
- Medical Imaging and Pathology Studies
Kangdong Sacred Heart Hospital
2012-2023
Hallym University Medical Center
2006-2023
Hallym University
2012-2021
Hallym University Kangnam Sacred Heart Hospital
2018
Hallym Polytechnic University
2016
Columbia University
2013
Inserm
2009
Assistance Publique – Hôpitaux de Paris
2009
Institute for Transfusion Medicine
2009
Hôpital Beaujon
2009
Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, underlying mechanisms remain largely elusive. Moreover, not known whether other mononuclear phagocytes such as dendritic cells (DCs) contribute to stellate cell (HSC) activation and fibrosis. We show for first time enhance myofibroblast survival nuclear factor kappa B (NF-κB)-dependent manner thereby promote Microarray pathway analysis revealed no induction HSC pathways by but...
To address a growing concern about drug-induced liver injury (DILI), nationwide study was performed to investigate the significance of DILI in Korea.From May 2005 2007, cases (alanine transferase > 3 × upper normal limit or total bilirubin 2 limit) from 17 referral university hospitals were prospectively enrolled. Adjudication by seven review boards considered for confirmation causality and Roussel Uclaf Causality Assessment Method (RUCAM) scale used.A 371 diagnosed with DILI. The...
Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs have been implicated in the development fibrosis cancer, thus constituting potential therapeutic targets. Here, we investigated role microRNA‐21 (miR‐21), a microRNA that has multiple organs also suggested to act as an “oncomir.” Accordingly, miR‐21 was showed strongest up‐regulation activated hepatic stellate cells (HSCs) models fibrogenesis, with 8‐fold 24‐fold induction compared quiescent HSCs....
Metastatic tumor antigen 1 (MTA1) is known to play a role in angiogenic processes as stabilizer of hypoxia-inducible factor 1-alpha (HIF1-alpha). In this study, we examined whether overexpression MTA1 affects the recurrence hepatocellular carcinoma (HCC) after surgical resection and survival patients. A total 506 HCC patients who underwent hepatic were included study. They followed up for median 43 months (range, 1-96 months) hepatectomy. expression levels determined by proportion...
This study was aimed to find clinical predictors for developing delirium tremens (DT) in alcohol dependence.This cohort retrospectively carried out among patients who were diagnosed as having dependence between January 2001 and July 2004. Fifteen parameters compared developed DT ones did not. We identified by using multivariate analysis.A total of one hundred seventy-eight consecutive admission cases from 147 analyzed. The mean age 47.8 years, 95.5% male. Delirium 59 (33%) during...
Background/Aim Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are most widely used tumor markers in detecting hepatocellular carcinoma (HCC). Recently, there have been some studies about them as prognostic hepatitis C virus-associated HCC. However, values of AFP PIVKA-II remain clarified B virus (HBV)-associated This study was aimed to evaluate the HBV-associated Methods Patients (n=126) were divided into 4 groups according median levels (L;...
There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare them in treatment-naïve chronic hepatitis B (CHB). Out of 345 CHB patients who received first line therapy with ETV (n = 200) or TDF 145) a cohort, 210 were analyzed using propensity score matching, at ratio 1:1. Two groups showed no difference baseline characteristics. During follow-up 12 months, HBV DNA levels similarly...
<i>Objectives:</i> The study was aimed to investigate the relationship between plasma transforming growth factor beta 1 (TGF-β<sub>1</sub>) expression and characteristics of hepatocellular carcinoma (HCC). <i>Methods:</i> Five hundred seventy-one patients with HCC were subjected. Plasma TGF-β<sub>1</sub> levels measured by enzyme-linked immunosorbent assay at diagnosis compared in accordance clinical radiological characteristics....
The simultaneous detection of hepatitis B surface antigen (HBsAg) and antibody to (anti-HBs) is unusual in chronic virus (HBV) infection, but may be related with more advanced liver diseases. This retrospective long-term cohort study was aimed investigate whether coexistence HBsAg anti-HBs increase the risk hepatocellular carcinoma (HCC) HBV infection. A total 1,042 non-HCC patients were recruited followed up for a median 4.3 years (range 1.0-22 years). Univariate multivariate analyses...
Summary. Cytotoxic T lymphocytes are essential components of immune responses during chronic hepatitis B (CHB). It has been known that Fas ligand (FasL) and perforin/granzyme B‐based mechanisms account for all cell‐mediated cytotoxicity. In the present work, we examined correlation between injury hepatocytes mRNA expression FasL in liver tissue to investigate roles both pathways CHB. Reverse transcription‐polymerase chain reaction was used identify intrahepatic biopsy specimens from 24...
Background/Aims We investigated the prevalence and relationship of peptic ulcer disease Helicobacter pylori infection to liver cirrhosis. Methods examined 288 patients with cirrhosis, 322 non-ulcer dyspepsia, 339 disease. Rapid urease test Wright-Giemsa staining were used for diagnosis H. infection. Results The in cirrhosis was 24.3%. divided into Child-Pugh classes A, B, C 22.3%, 21.0%, 31.3%, respectively (p>0.05). without chronic 35.1%, 62.4%, 73.7%, (p<0.001). did not differ depending on...
Interleukin (IL)-1 gene polymorphism has been reported to be associated with the increment of gastric cancer (GC) and decrement duodenal ulcers (DU). In addition, IL-2 is known induce Helicobacter pylori (H. pylori)-associated atrophy, but it not whether increases risk GC or peptic ulcer diseases. Therefore, we compared genotypes IL-1B, IL-1RN, polymorphisms (GU), GC, DU in Korean patients.In total, 116 GU, 122 104 patients were included consecutively 100 healthy controls. Polymorphisms...
Abstract Antibody to hepatitis B surface antigen (HBsAg) (anti‐HBs) can exist in patients with chronic virus (HBV) infection. To date, little is known about the association of concurrent HBsAg and anti‐HBs (concurrent HBsAg/ anti‐HBs) hepatocellular carcinoma (HCC). The aim this study was investigate clinical relevance HBsAg/anti‐HBs preS deletion mutations HCC HBV A total 755 infection were included consecutively at a tertiary center. Logistic regression analysis used identify risk factors...
Clarithromycin resistance in Helicobacter pylori is associated with point mutations the 23S ribosomal RNA (rRNA) gene. We investigated rRNA genes of patients clarithromycin-resistant H. and compared eradication rates based on mutations.A total 431 adult infection were recruited Kangdong Sacred Heart Hospital 2017 2018. Patients who did not have related to clarithromycin and/or had clinically insignificant treated PAC (proton pump inhibitor, amoxicillin, clarithromycin) for seven days, while...
This study was performed to find clinical risk factors for developing ischemic colitis in patients experiencing lower abdominal discomfort with or without bloody diarrhea.A total of 467 who underwent sigmoidoscopy colonoscopy because discomforts blood stool were consecutively enrolled; 147 diagnosed endoscopically and histologically as having colitis. The control group composed the remaining 320 nonspecific endoscopic/histologic findings. Clinical variables compared between group.After...
Portal hypertensive gastropathy (PHG) is a frequently overlooked complication of liver cirrhosis (LC). The clinical implications PHG as prognostic factor LC or predictive for the development hepatocellular carcinoma (HCC) have not been established. aim this study was to assess significance in patients with LC. Patients were prospectively enrolled and followed single tertiary hospital Republic Korea. Baseline hepatic vein pressure gradient (HVPG) measured, esophagogastroduodenoscopy (EGD)...
Budd-Chiari syndrome (BCS) is a known risk factor for hepatocellular carcinoma (HCC). Considering the pathophysiological mechanism of BCS, BCS-associated HCC may have different carcinogenic process to hepatitis B virus (HBV)-associated HCC, resulting in characteristic clinical features.The clinical, radiological and histopathological characteristics 15 HCCs associated with BCS were analysed compared 211 HBV-associated HCCs.HCC showed female predominance contrast male HBV infection. Child...
We analyzed serologic data that were obtained from the Korea Association of Health 1995 to 1999 estimate reliable prevalence HBV in South Korea.603,375, 639,465, 621,476, 612,705 and 650,398 serum samples annually tested for HBsAg. Of HBsAg positive persons whose available, HBeAg positivity was checked.HBsAg positivities among subjects between 6 19 years old 8.2%, 3.9%, 2.1%, 2.6% 1.3%. above 20 8.9%, 6.4%, 5.9%, 5.4% 5.4%. The rates 39.8 62.9% old, 18.3 37.9% each year. In both subgroups,...
Summary Background Asthma can frequently be induced or exacerbated by respiratory viral infections. Oxidative stress might also play an essential role in the pathogenesis of allergic airway diseases, indicating that antioxidant therapy may have a potential effect controlling diseases. Recent studies showed 5‐aminoimidazole‐4‐carboxamide‐1‐β‐4‐ribofuranoside (AICAR) has ability to modulate NADPH oxidase activity, activity AICAR. This study investigated inhibitory effects AICAR as...