A5068487914- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatitis Viruses Studies and Epidemiology
- Gallbladder and Bile Duct Disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- Biliary and Gastrointestinal Fistulas
Kyungpook National University Hospital
2015-2024
Kyungpook National University
2015-2024
GlaxoSmithKline (India)
2024
University of Maryland, Baltimore
2022
Bio-Medical Science (South Korea)
2015
Yonsei University
2015
University of North Carolina at Chapel Hill
2001-2003
To address a growing concern about drug-induced liver injury (DILI), nationwide study was performed to investigate the significance of DILI in Korea.From May 2005 2007, cases (alanine transferase > 3 × upper normal limit or total bilirubin 2 limit) from 17 referral university hospitals were prospectively enrolled. Adjudication by seven review boards considered for confirmation causality and Roussel Uclaf Causality Assessment Method (RUCAM) scale used.A 371 diagnosed with DILI. The...
Exosomal noncoding RNAs (ncRNAs) have unique expression profiles reflecting the characteristics of a tumor, and their role in tumor progression metastasis is emerging. However, significance circulating exosomal ncRNAs prognosis hepatocellular carcinoma (HCC) remains to be elucidated. We therefore determined prognostic (miRNA-21 lncRNA-ATB) for human HCC. This prospective study enrolled 79 HCC patients between October 2014 September 2015. Exosomes were extracted from serum samples using...
Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from cirrhosis and hepatocellular carcinoma. Functional cure rates are low current treatment options (nucleos(t)ide analogs (NAs) pegylated interferons). Bepirovirsen is antisense oligonucleotide targeting all HBV messenger RNAs; in cell culture animal models, bepirovirsen reductions HBV-derived RNAs, DNA viral proteins. This phase 2 double-blinded, randomized, placebo-controlled trial the first evaluation...
Transforming growth factor β (TGF–β) is the most potent profibrogenic mediator in liver fibrosis. Although Smad proteins have been identified as intracellular mediators TGF–β signaling pathway, function of individual remains poorly understood. The aim this study was to explore contribution Smad3 mediating responses a model acute injury vivo and culture–activated hepatic stellate cells (HSCs). Wild–type, heterozygous or homozygous knockout mice were treated with single intragastric...
Background/Aims: Treating hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains controversial. We compared the outcomes of hepatic resection (HR), transarterial chemoembolization (TACE), and sorafenib therapy as treatments for HCC PVTT. Methods: Patients diagnosed PVTT between January 2000 December 2011 who received treatment sorafenib, HR, or TACE were included. main PVTT, superior mesenteric thrombosis, Child-Turcotte-Pugh (CTP) class C excluded. The records 172...
Abstract Activated hepatic stellate cells (HSCs) are the main producers of extracellular matrix in fibrotic liver and contribute to inflammation through secretion chemokines recruitment leukocytes. This study assesses function CD40 on human HSCs. HSCs express culture liver, as determined by flow cytometry, RT-PCR, immunohistochemistry. expression is strongly enhanced IFN-γ. Stimulation with ligand (CD40L)-transfected baby hamster kidney induces NF-κB, demonstrated activation I-κB kinase...
Clevudine is a pyrimidine analogue with potent and sustained antiviral activity against HBV. The present study evaluated the safety efficacy of 30 mg clevudine once daily for 24 weeks assessed durable response after cessation dosing. A total 243 hepatitis B e antigen (HBeAg)-positive chronic patients were randomized (3:1) to receive (n = 182) or placebo 61) weeks. Patients followed further off therapy. Median serum HBV DNA reductions from baseline at week 5.10 0.27 log10 copies/mL in groups,...
See also: Commentaire de travail D. S. Lee et al., pp. 647Endoscopy 2010; 42(08): 994-994DOI: 10.1055/s-0032-1306703
Clevudine is a pyrimidine analog with potent and sustained antiviral activity against HBV. In the present study, we evaluated safety efficacy of clevudine 30 mg daily for 24 weeks assessed durability response after cessation dosing in hepatitis B e antigen (HBeAg)-negative chronic (e-CHB). We randomized total 86 patients (3:1) to receive (n = 63) or placebo 23) weeks. followed an additional withdrawal treatment. The median changes HBV DNA from baseline were -4.25 -0.48 log(10) copies/mL at...
See also: Commentaire de travail D. Park et al., pp. 7Endoscopy 2008; 40(01): 88-89DOI: 10.1055/s-0032-1306799
<h3>Background</h3> Besifovir (LB80380) is an acyclic nucleotide phosphonate effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic (CHB) patients preliminary studies. <h3>Design</h3> We aimed to compare the safety antiviral activity of two doses besifovir (90 mg 150 daily) with entecavir 0.5 daily CHB patients. 114 were randomised receive 90 (n=36), (n=39) or (n=39). HBV liver biochemistry, including serum L-carnitine levels,...
Summary Background Anti‐viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune‐tolerant phase. Aims To investigate cumulative incidence of phase change and hepatocellular carcinoma (HCC) independent predictors CHB Methods In total, 946 phase, defined as e antigen positivity, HBV‐DNA >20 000 IU/mL alanine aminotransferase (ALT) ≤40 IU/L, between 1989 2017 were enrolled from eight institutes. Results The mean age study population (429 men 517 women) was...
Obesity tends to be associated with increased mortality and morbidity in acute pancreatitis. However, Asian populations, higher have been reported patients low body mass indexes (BMIs). This study was undertaken evaluate the relation between obesity outcome, investigate occurrence of complications by overweightedness pancreatitis.The medical records 403 pancreatitis were reviewed retrospectively, Ranson's scores, modified Glasgow Acute Physiology Chronic Health Evaluation (APACHE) II scores...
Evidence of the potential benefits long-term oral branched-chain amino acid (BCAA) supplementation in reducing severity liver disease is limited.Patients who were diagnosed with cirrhosis a Child-Pugh (CP) score 8-10 included. The BCAA group consumed BCAAs daily for at least 6 months, and control diet without BCAA. We analyzed improvements based on model end-stage (MELD) score, CP incidence cirrhosis-related complications, event-free survival over 2 years. Among 867 recruited patients, 307...
Clinical evidence for the benefits of branched-chain amino acids (BCAAs) is lacking in advanced liver disease. We evaluated potential long-term oral BCAA supplementation patients with disease.Liver cirrhosis Child-Pugh (CP) scores from 8 to 10 were prospectively recruited 13 medical centers. Patients supplemented 12.45 g daily granules over 6 months, and consuming a regular diet assigned control groups, respectively. The effects using model end-stage disease (MELD) score, CP serum albumin,...
The role of body composition parameters in sorafenib-treated hepatocellular carcinoma (HCC) patients is still not fully elucidated. Here, we aimed to evaluate the impact computed tomography (CT)-based on survival such patients. In this multicenter study, analyzed data 245 HCC from January 2008 December 2019. Sarcopenia, visceral obesity, and myosteatosis were defined by using cross-sectional CT images at third lumbar vertebra level. effects these overall (OS) progression-free (PFS)...