A5101915658- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Long-Term Effects of COVID-19
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Organ Transplantation Techniques and Outcomes
- Neuroblastoma Research and Treatments
- Gallbladder and Bile Duct Disorders
- Endoplasmic Reticulum Stress and Disease
- Mycobacterium research and diagnosis
- Cardiovascular Function and Risk Factors
- Acupuncture Treatment Research Studies
- Amoebic Infections and Treatments
- COVID-19 and healthcare impacts
- IgG4-Related and Inflammatory Diseases
- Cancer Mechanisms and Therapy
- COVID-19 diagnosis using AI
Catholic University of Daegu
2014-2024
Daegu Catholic University Medical Center
2015-2023
Yonsei University
2016-2017
Severance Hospital
2017
Creative Research Enterprises (United States)
2016
Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare and difficult to distinguish from other liver tumors, such as hepatocellular carcinoma (HCC) cholangiocarcinoma, based on medical imaging findings. A 70-year-old man was referred for evaluation of mass incidentally discovered abdominal computed tomography. The characteristic finding dynamic magnetic resonance led a diagnosis HCC. patient underwent right hepatectomy. Histopathological immunohistochemical examination revealed...
The role of body composition parameters in sorafenib-treated hepatocellular carcinoma (HCC) patients is still not fully elucidated. Here, we aimed to evaluate the impact computed tomography (CT)-based on survival such patients. In this multicenter study, analyzed data 245 HCC from January 2008 December 2019. Sarcopenia, visceral obesity, and myosteatosis were defined by using cross-sectional CT images at third lumbar vertebra level. effects these overall (OS) progression-free (PFS)...
The reliable risk factors for mortality of COVID-19 has not evaluated in well-characterised cohort. This study aimed to identify in-hospital within 56 days patients with severe infection COVID-19.Retrospective multicentre cohort study.Five tertiary hospitals Daegu, South Korea.1005 participants over 19 years old confirmed using real-time PCR from nasopharyngeal and oropharyngeal swabs.The clinical laboratory features receiving respiratory support were analysed ascertain the Cox proportional...
Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver on outcome COVID-19 remains unresolved.<br/>.A total 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed included this study. Clinical outcomes coexisting as well predictors severity and mortality assessed.<br/>.Of 47 (4.7%) had liver-related comorbidities, 14 (1.4%) cirrhosis. Liver cirrhosis was more common severe pneumonia than...
Cholestatic liver diseases can progress to end-stage disease and reduce patients’ quality of life. Although their underlying mechanisms are still incompletely elucidated, oxidative stress is considered be a key contributor these diseases. Heme oxygenase-1 (HO-1) cytoprotective enzyme that displays antioxidant action. It has been found this plays protective role against various inflammatory However, the HO-1 in cholestatic not yet investigated. Here, we examined whether pharmacological...
Objective It remains controversial whether certain treatments should apply to HCC patients with ascites due concerns about worsening liver function. The objective of the present study is compare prognostic performance 4 function models currently in use for ascites. Methods A total 437 treatment-naïve, newly diagnosed were analyzed. predictive Child-Pugh, MELD, MELD-Na, and ALBI scores examined using ROC curve analysis.Results MELD-Na score showed good predicting 1-, 2-, 3-year mortality,...
Background/Aims The optimal management of patients exhibiting a partial virologic response (PVR) to entecavir (ETV) has not been determined. aim this study was determine the long-term efficacy prolonged ETV monotherapy in treatment-naïve chronic hepatitis B (CHB) PVR therapy. Methods This included 364 CHB treated with for â¥48 weeks and who received continuous â¥96 weeks. defined as decrease serum virus (HBV) DNA more than 2 log10 IU/mL from baseline but detectable HBV by real-time PCR...
Chronic hepatitis B is the most common cause of liver cirrhosis in South Korea. However, alcoholic disease has shown an increasing trend. Although clinical implications surrounding have been changing over years, few studies recently examined epidemiology. Therefore, we aimed to investigate changes etiology and severity Korea.We retrospectively reviewed 16,888 records cirrhotic patients from six tertiary hospitals Korea 2008 2017. Continuous non-continuous variables were processed via linear...
Non-alcoholic steatohepatitis (NASH) is becoming an increasingly serious global health threat, distinguished by hepatic lipid accumulation, inflammation, and fibrosis. There a lack of approved pharmaceutical interventions for this disease, highlighting the urgent need effective treatment. This study explores hepatoprotective potential 6-shogaol, natural compound derived from ginger, in methionine- choline-deficient (MCD) dietary mouse model NASH. Male C57BL/6J mice were subjected to MCD diet...
It is unclear whether chronic hepatitis B (CHB) patients with antiviral resistance, who achieve a complete virologic response (CVR) tenofovir disoproxil fumarate (TDF) and nucleoside analogue (NUC) combination therapy, maintain CVR if switched to TDF monotherapy. We investigated the persistence of after cessation NUC in virologically suppressed resistant CHB using TDF+NUC therapy. This study recruited 76 antiviral‐resistant showing on TDF+entecavir (ETV) ( n = 52), TDF+lamivudine (LAM; 14),...
See the article "A Prospective Blinded Study of Endoscopic Ultrasound Elastography in Liver Disease: Towards a Virtual Biopsy" Volume 51 on page 181.
Acute gastroesophageal variceal hemorrhage is a dreaded complication in patients with liver cirrhosis. Endoscopic therapy and radiologic intervention for bleeding have rapidly developed the recent decades. treatment initially performed to stop hemorrhage. For of esophageal bleeding, endoscopic ligation (EVL) considered choice. In cases gastric hemorrhage, type varices (GVs) important deciding strategy treatment. obturation (EVO) recommended fundal bleeding. management varix 1 both EVO EVL...
To select appropriate empirical antibiotics, updates on the changes in pathogens are essential. We aimed to investigate and their antibiotic susceptibility acute cholangitis (AC) with bacteremia over a period of 15 years. Furthermore, efficacy therapies risk factors predicting antibiotic-resistant (ARPs) were analyzed.A total 568 patients AC who admitted Daegu Catholic University Medical Center from January 2006 December 2020 included. Their medical records retrospectively reviewed. In...
The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed evaluate the long-term efficacy prolonged TDF therapy in treatment-naïve CHB PVR real practice.We retrospectively investigated TDF. was defined as a decrease serum virus (HBV) DNA over 2 log10 IU/mL from baseline, detectable HBV by real-time polymerase chain reaction at week 48.We included 232 who underwent for 48 weeks. Forty-two...
Previous studies have reported a high rate of sustained virologic response (SVR) and low serious adverse events with the use daclatasvir (DCV) asunaprevir (ASV) combination therapy. We evaluated efficacy safety DCV ASV therapy for patients chronic hepatitis C virus (HCV) genotype 1b infection in real world.We enrolled 278 (184 treatment-naïve patients) from five hospitals Daegu Gyeongsangbuk-do. rates rapid (RVR), end-of-treatment (ETR), SVR at 12 weeks after completion treatment (SVR12)....
Objective The liver stiffness-based risk prediction models predict hepatocellular carcinoma (HCC) development. We investigated the influence of antiviral therapy (AVT) on model in patients with chronic hepatitis B (CHB). Methods Patients CHB who initiated AVT were retrospectively recruited from 13 referral Korean institutes. modified estimation for (mREACH-B) was selected analysis. Results Between 2007 and 2015, 1034 recruited. mean age study population (639 men 395 women) 46.8 years. During...
Recent data indicate the presence of liver enzyme abnormalities in patients with coronavirus disease 2019 (COVID-19). We aimed to evaluate clinical features and treatment outcomes COVID-19 abnormal enzymes.We performed a retrospective, multicenter study 874 admitted five tertiary hospitals from February 20 April 14, 2020. Data on features, laboratory parameters, medications, were collected until 30, 2020, compared between normal aminotransferases.Abnormal aminotransferase levels observed 362...
Chronic hepatitis B is an important public health concern. Introduction of oral nucleos(t)ide analogs (NAs), inhibitors virus (HBV) polymerase, was a milestone that lowered the high viral loads associated with increased risk liver-related complications.Although currently available NAs are effective in suppressing replication, anti-HBV treatment principle requires lifelong drug administration, and some patients have limitations such as incidence liver cancer likelihood toxicities following...
<title>Abstract</title> <bold>Background: </bold>Bacterial infections are an important prognostic factor in patients with severe alcoholic hepatitis (SAH). However, it is difficult to detect the presence of infection immediately. Procalcitonin (PCT) a well-known inflammatory marker that can bacterial various diseases early. Therefore, we aimed evaluate diagnostic accuracy PCT for SAH. <bold>Methods:</bold> We prospectively enrolled SAH from 10 medical centers. Upon admission, performed...