A5072844970- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Amoebic Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Cancer Mechanisms and Therapy
- HIV/AIDS drug development and treatment
- Endoplasmic Reticulum Stress and Disease
- Urinary Tract Infections Management
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Gastroesophageal reflux and treatments
Soonchunhyang University
2016-2025
Bucheon University
2017-2025
Soonchunhyang University Hospital
2017-2024
National Evidenc- based healthcare Collaborating Agency
2024
Inje University Busan Paik Hospital
2023
Hospital Universitario Fundación Jiménez Díaz
2022
Seoul National University
2013-2019
Eulji University
2019
Seoul Metropolitan Government
2017
Boramae Medical Center
2017
Evidence collectionThe committee systematically collected and reviewed the international domestic literature published in PubMed, MEDLINE, KoreaMed, other databases.The was limited to research papers English Korean languages.The keywords used were 'nonalcoholic fatty liver disease,' liver,' steatohepatitis,' 'fatty 'hepatic steatosis,' 'steatohepatitis.'In addition, related specific clinical questions included. Levels of evidence grades recommendationsThe gathered for data collection...
ABSTRACT While entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effectively manage chronic hepatitis B, their long‐term effects on lipid metabolism cardiovascular outcomes remain unclear. This study compares the impact of ETV, TDF, treatment‐naïve (control group) hyperlipidemia major adverse cardiac events (MACE) in people living with B (PLWHB). We used claim data from South Korean National Health Insurance Service. Propensity score matching was to account for confounding factors. The...
Antiplatelet therapy has shown protective effects against hepatocellular carcinoma (HCC) in preclinical studies. However, it is unclear whether antiplatelet lowers the risk of HCC patients with chronic hepatitis B. A retrospective analysis was conducted data from 1,674 B patients, enrolled between January 2002 and May 2015, whose serum virus DNA levels were suppressed by antivirals to <2,000 IU/mL. The primary secondary outcomes development bleeding events, respectively. Risk compared...
Rifaximin might decrease the risk of portal hypertension-related complications by controlling small intestinal bacterial overgrowth.To evaluate whether rifaximin was associated with death and cirrhotic complications.We conducted a retrospective study that included 1042 patients experiencing hepatic encephalopathy (HE): 421 without hepatocellular carcinoma (HCC; non-HCC cohort) 621 HCC (the cohort). The primary endpoint overall survival secondary endpoints were recurrence HE development...
Background/Aims: Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV).This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic (CHC).Methods: This multicenter, retrospective included 8,819 diagnosed CHC who were treated DAAs and achieved a sustained virological response (SVR) between January 2014 December 2022.Fibrosis was defined as 20% reduction noninvasive surrogates for...
Abstract Population-based data regarding the prognostic implication of gamma-glutamyl transferase (GGT) have been inconsistent. We examined association GGT with all-cause and disease-specific mortality. Using Korean nationwide database, we included 9,687,066 subjects without viral hepatitis or cirrhosis who underwent a health examination in 2009. Subjects were classified into three groups by sex-specific tertile serum levels. The underlying causes death 10th Revision International...
The histologic status of the immune-tolerant (IT) phase chronic hepatitis B relative to long-term outcomes is unclear. This study aimed discover how serological criteria currently in use correspond determining IT and indication for liver biopsy. Patients determined by positive e antigen, virus (HBV) DNA ≥106 IU/mL, normal or minimally elevated alanine aminotransferase (ALT) ≤60 IU/L, who underwent biopsy at three different hospitals were included. distribution phase, defined as fibrosis...
Abstract Background Metabolic-associated fatty liver disease (MAFLD) encompasses diverse groups with potentially heterogeneous clinical outcomes. We investigated the risk of all-cause and disease-specific mortality in MAFLD subgroups. Methods Using Korean National Health Insurance Service database, participants were divided into four subgroups: no MAFLD, MAFLD-diabetes, MAFLD-overweight/obese, MAFLD-lean. Hazard ratios (HRs) 95% confidence interval (CI) values for according to subgroups...
The association of smoking with hepatocellular carcinoma (HCC) or cardiovascular disease (CVD) has been reported, but the study its relationship metabolic-associated fatty liver (MAFLD) is limited. We aimed to investigate effect on incidence HCC CVD in MAFLD patients. Using Korean nationwide health screening database, we analyzed subjects between 2001 and 2015. A total 283,088 including 110,863 patients 172,225 controls were analyzed. Smoking status was divided by non-smoker, ex-smoker,...
Abstract Background & Aims Accurate prognostication of acute‐on‐chronic liver failure ( ACLF ) is essential for therapeutic decisions. Our aim was to validate a novel scoring system predicting mortality, the chronic failure‐sequential organ assessment CLIF ‐ SOFA ), in population Asian patients with . Methods A total 345 acutely decompensated alcoholic cirrhosis were selected study, comparing areas under receiver operating characteristic AUROC curves and five existing systems end‐stage...
The utility of fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET/CT) in initial staging hepatocellular carcinoma (HCC) has yet to be fully explored. We assessed the usefulness (18)F-FDG PET/CT HCC.A total 457 consecutive patients initially diagnosed with HCC at Seoul National University Hospital between 2006 and 2012 were evaluated retrospectively assess impact on compliancy Milan criteria, relative dynamic CT liver chest x-ray.Seven among...
Traditionally, the diagnostic mainstay of recurrent urinary tract infection has been culture. However, causative uropathogen cystitis not well established. Urine DNA next-generation sequencing (NGS) can provide additional information on these infections. Herein, we compared urine NGS results and cultures in patients with acute uncomplicated (AUC) (RC), evaluated difference microbiome patterns results. Patients who underwent culture due to AUC or RC were retrospectively reviewed. All samples...
Although the epidemiology of pyogenic liver abscess (PLA) continues to change, only a few population-based studies have been conducted in Korea. This study investigated and clinical outcomes PLA patients during period 10 years.We analysed Health Insurance Review Assessment Service data between 2007 2017. The included annual incidence rates, demographic data, underlying diseases, complications mortality patients.The for all age groups was 10.9 per 100 000 population. gradually increased from...
Background and Aims: Altered lipid metabolism has been implicated in the development of hepatocellular carcinoma (HCC). This study investigated relationships between profiles HCC development. Methods: Data were obtained from Korean National Health Insurance Service 2009 to 2017. Cox regression analysis was used examine hazard ratios 8,528,790 individuals who had undergone health check-ups 2009. Results: During a median 7.3 years follow-up, 26,891 incidents HCCs identified. The incidence (per...
Background/Aims Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect progression chronic disease (CLD) or cirrhosis (LC). Variations exist in patient demographics prognostic outcomes AD based on aetiology CLD, encompassing LC. However, limited research has been conducted analyse these discrepancies across aetiologies.