A5101732381- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Dietary Effects on Health
- Lymphoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Cancer, Lipids, and Metabolism
- HIV/AIDS drug development and treatment
- Organ Transplantation Techniques and Outcomes
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Salivary Gland Disorders and Functions
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Salivary Gland Tumors Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Chemotherapy-induced cardiotoxicity and mitigation
- Immunotherapy and Immune Responses
- Spinal Fractures and Fixation Techniques
Chung-Ang University Hospital
2024-2025
Chung-Ang University
2024-2025
Ewha Womans University
2019-2024
Korea University
2016-2023
Ewha Womans University Medical Center
2022-2023
Yonsei University
2023
Graduate School USA
2022
Baewha Women's University
2022
Korea University Medical Center
2020-2022
Inje University Sanggye Paik Hospital
2021-2022
Objective We explored clinical implications of the new definition metabolic dysfunction-associated steatotic liver disease (MASLD) by assessing its prevalence and associated cardiovascular (CVD) risk. Design From nationwide health screening data, we identified 9 775 066 adults aged 20–79 who underwent examination in 2009. Participants were categorised into four mutually exclusive groups: (1) MASLD; (2) MASLD with increased alcohol intake (MetALD); (3) other combined aetiology (the three...
Summary Background Anti‐viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune‐tolerant phase. Aims To investigate cumulative incidence of phase change and hepatocellular carcinoma (HCC) independent predictors CHB Methods In total, 946 phase, defined as e antigen positivity, HBV‐DNA >20 000 IU/mL alanine aminotransferase (ALT) ≤40 IU/L, between 1989 2017 were enrolled from eight institutes. Results The mean age study population (429 men 517 women) was...
The histologic status of the immune-tolerant (IT) phase chronic hepatitis B relative to long-term outcomes is unclear. This study aimed discover how serological criteria currently in use correspond determining IT and indication for liver biopsy. Patients determined by positive e antigen, virus (HBV) DNA ≥106 IU/mL, normal or minimally elevated alanine aminotransferase (ALT) ≤60 IU/L, who underwent biopsy at three different hospitals were included. distribution phase, defined as fibrosis...
Summary Background Proton pump inhibitors (PPI) are frequently used in patients with cirrhosis. Aims This study aimed to determine whether PPI use is associated the prognosis of cirrhotic patients. Methods We conducted a multicentre retrospective cohort involving 1485 who had experienced hepatic encephalopathy (HE) from 7 referral centres Korea. The primary outcome was overall survival and secondary outcomes included development complications, including recurrent HE, spontaneous bacterial...
Long-term antiviral therapy (AVT) for chronic hepatitis B (CHB) reduces the risk of hepatocellular carcinoma (HCC). We assessed temporal trends in incidence HCC over time during long-term AVT among Asian patients with CHB.Patients CHB receiving entecavir/tenofovir (ETV/TDF) as a first-line were recruited from four academic hospitals Republic Korea. compared and after first 5 years ETV/TDF treatment.Among 3,156 patients, median age was 49.6 males predominated (62.4%). During follow-up, 9.0%...
Abstract Background Natural killer (NK) cells have been known to contribute surveillance and control of hepatocellular carcinoma (HCC). However, the association NK cell activity with stage recurrence risk HCC not fully evaluated. Methods Untreated patients newly diagnosed were prospectively enrolled. Peripheral blood mononuclear isolated at time diagnosis. Patients who had undergone surgery or radiofrequency ablation classified as curative treatment group, their samples collected again 1...
Background/AimsBesifovir (BSV) showed comparable antiviral activity superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB).However, no data are available regarding the efficacy and of BSV patients with CHB who switched from long-term TDF BSV.This study aimed evaluate outcome a 48-week therapy treatment. MethodsIn this non-inferiority trial, 153 treated for ≥48 weeks had virus (HBV) DNA <20 IU/mL were randomized receive either 150 mg or...
Hepatocellular carcinoma (HCC) presents unique challenges in both the elderly and adolescent/young adult (AYA) populations, requiring distinct management approaches. Recent epidemiological data show an increasing incidence of HCC age groups, with cases rising significantly AYA showing trends specific regions. The clinical characteristics treatment considerations vary substantially among these populations. Elderly patients typically present hepatitis C virus infection, metabolic...
ABSTRACT Background Antiviral therapy (AVT) reduces the risk of hepatitis B virus–related hepatocellular carcinoma (HCC). Aims The difference in HCC after surface antigen (HBsAg) seroclearance to AVT status was explored. Methods Patients with chronic who achieved HBsAg were retrospectively evaluated. primary outcome development seroclearance. Results Of study population, 1280 (84.2%) and 241 (15.8%) patients without (spontaneous clearance group) (AVT‐induced group), respectively. cumulative...
Hepatocellular carcinoma (HCC) is the sixth most common cancer and second leading cause of cancer-related death in Korea. This study evaluated characteristics Korean patients newly diagnosed with HCC 2015.
ABSTRACT Background & Aims Non‐selective β‐blockers (NSBBs) and endoscopic variceal‐ligation (EVL) have similar efficacy preventing first variceal bleeding. Compensated decompensated cirrhosis are markedly different stages, which may impact treatment outcomes. We aimed to assess the of NSBBs vs EVL on survival in patients with high‐risk varices without previous bleeding, stratifying risk according compensated/decompensated stage cirrhosis. Methods By systematic review, we identified RCTs...
Background/Aims: Transarterial radioembolization (TARE) has shown promising results in treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). However, whether TARE can provide superior or comparable outcomes to tyrosine kinase inhibitor (TKI) patients HCC and PVTT remains unclear. We compared the of TKI therapy treatment-naïve locally segmental lobar PVTT.Methods: This multicenter study included 216 initially treated (n=124) (sorafenib lenvatinib; n=92)...
A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients chronic hepatitis B (CHB). We investigated whether the achievement sc-LS antiviral therapy (AVT) reduced risk developing hepatocellular carcinoma (HCC) CHB-related advanced fibrosis or cirrhosis.In total, 209 cirrhosis, who received paired elastography examinations during AVT between 2007 and 2012, were enrolled. The cut-off LS value for ultrasonographic...
Han Ah Lee, Young-Sun Beom Kyung Kim, Young Kul Jung, Seung Up Jun Yong Park, Ji Hoon Hyunggin An, Do Hyung Joon Yim, Sang Ahn, Jong Eun Yeon, Kwan Soo Byun, Kwang-Hyub Han, Soon Ho Um, and Yeon Seok Seo. Gut Liver 2021;15:420-9. https://doi.org/10.5009/gnl20101
Considering the high prevalence and mortality of hepatocellular carcinoma (HCC) in Korea, accurate statistics for HCC are important. We evaluated characteristics Korean patients with newly diagnosed HCC.
Backgrounds/Aims: In Korea, hepatocellular carcinoma (HCC) is the sixth most common cancer and results in second-highest death rate among all cancers. We aimed to describe characteristics of patients who were newly diagnosed with HCC Korea between 2008 2011.The Korean Primary Liver Cancer Registry (KPLCR) a random sample consisting approximately 15% primary liver registered Central Registry. investigated baseline characteristics, treatment modalities, overall survival (OS) KPLCR 2011.A total...
Background: The platelet-to-white blood cell ratio (PWR) is a hematologic marker of the systemic inflammatory response. Recently, PWR was revealed to have role as an independent prognostic factor for mortality in patients with hepatitis B virus (HBV)-related acute-on-chronic failure (ACLF) and HBV-related liver cirrhosis (LC) acute decompensation (AD). However, still needs be investigated LC AD. In this study, we analyzed whether could stratify risk adverse outcomes (death or transplantation...
Summary Background Data on patients switched to tenofovir alafenamide (TAF) from nucleos(t)ide analogues (NUCs) other than disoproxil fumarate are limited. Aims To assess the treatment and renal/bone safety outcomes following switch TAF. Methods We prospectively enrolled adult with chronic hepatitis B (CHB) who any NUC TAF at 14 centres in Japan, Korea, Taiwan U.S. Study were viral suppression (VR; HBV DNA < 20 IU/mL), biochemical response (BR; alanine aminotransferase normalisation),...