A5003213219- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alcohol Consumption and Health Effects
- Cancer Mechanisms and Therapy
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Dietary Effects on Health
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Cancer Risks and Factors
Ewha Womans University
2016-2024
Ewha Womans University Medical Center
2020-2024
Graduate School USA
2022
Baewha Women's University
2020-2022
Boramae Medical Center
2013-2018
Seoul National University
2010-2017
Seoul Metropolitan Government
2013-2017
American Society of Clinical Oncology
2016
Seoul National University Hospital
2013
National Cancer Center
2011
To determine the efficacy and safety of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) main portal vein (MPV) invasion.This study was approved by institutional review board, requirement to obtain informed consent waived. The authors retrospectively assessed electronic medical records whom HCC MPV invasion newly diagnosed from January 2004 December 2007 at a single tertiary center. Patients decompensated hepatic function were excluded. Outcomes treated...
Sorafenib is first-line standard of care for patients with advanced hepatocellular carcinoma (HCC), yet it confers limited survival benefit. Therefore, we aimed to compare clinical outcomes sorafenib combined concurrent conventional transarterial chemoembolization (cTACE) vs. alone in HCC.In this investigator-initiated, multicenter, phase III trial, were randomized receive (Arm S, n = 169) or combination cTACE on demand C, 170). was started within 3 days and 7-21 randomization. The primary...
Objective We explored clinical implications of the new definition metabolic dysfunction-associated steatotic liver disease (MASLD) by assessing its prevalence and associated cardiovascular (CVD) risk. Design From nationwide health screening data, we identified 9 775 066 adults aged 20–79 who underwent examination in 2009. Participants were categorised into four mutually exclusive groups: (1) MASLD; (2) MASLD with increased alcohol intake (MetALD); (3) other combined aetiology (the three...
Goal In this study, we attempted to evaluate the prognosis of combined hepatocellular and cholangiocarcinoma (cHCC-CC) with comparison carcinoma (HCC) intrahepatic (CC). Background The cHCC-CC has not been fully elucidated. HCC CC. Study Consecutive patients who underwent curative resection for at a single tertiary care center in Korea their age, sex, Child-Turcotte-Pugh class matched CC were included. We evaluated time-to-recurrence (TTR) overall survival (OS) cases compared them patients....
To develop and validate a model to predict tumor recurrence after living donor liver transplantation (LDLT) (MoRAL) for hepatocellular carcinoma (HCC) beyond the Milan criteria (MC).Some subgroups of HCC exceeding MC experience substantial benefit from LDLT.This multicenter study included total 566 consecutive patients who underwent LDLT in Korea: beyond-MC cohort (n = 205, derivation [n 92] validation 113] sets) within-MC 361). The primary endpoint was time-to-recurrence.Using multivariate...
Nonalcoholic fatty liver disease (NAFLD) is associated with visceral obesity. However, the association between adipose tissue (VAT) area and fibrosis in NAFLD patients has not been completely established. This study was aimed to determine relationship computed tomography-measured VAT significant patients. A total of 324 132 controls were evaluated by biopsy. diagnosed based on histological examinations alcohol consumption <20 g/day. The showed a higher age gender-adjusted than control group...
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP HLA-DQ in Asian populations, as being associated with CHB. To confirm identify host genetic factors related to infection, we performed another GWAS using a higher-density chip Korean carriers. We analyzed 1400...
Pathophysiological background in different phenotypes of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. The aim was investigate the association between fecal and blood microbiota profiles presence NAFLD obese versus lean subjects. Demographic clinical data were reviewed 268 health checkup examinees, whose samples available for analysis. diagnosed with ultrasonography, subjects further categorized as (body mass index (BMI) ≥25) or (BMI <25). Fecal communities analyzed by...
Summary Background Proton pump inhibitors (PPI) are frequently used in patients with cirrhosis. Aims This study aimed to determine whether PPI use is associated the prognosis of cirrhotic patients. Methods We conducted a multicentre retrospective cohort involving 1485 who had experienced hepatic encephalopathy (HE) from 7 referral centres Korea. The primary outcome was overall survival and secondary outcomes included development complications, including recurrent HE, spontaneous bacterial...
Objective Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether was as safe after NA-induced surface antigen HBV (HBsAg) seroclearance investigated present study. Designs This multicentre study included 276 from 16 hospitals Korea HBsAg seroclearance: 131 (47.5%) discontinued treatment within 6 months (NA group) and 145 (52.5%)...
Hepatocellular carcinoma (HCC) is the sixth most common cancer and second leading cause of cancer-related death in Korea. This study evaluated characteristics Korean patients newly diagnosed with HCC 2015.
Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) for the prevention of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B; however, it has distinct long-term renal and bone toxicities. This study aimed develop validate a machine learning model (designated as Prediction Liver cancer using Artificial intelligence-driven Network-antiviral Selection B [PLAN-S]) predict an individualized risk HCC during ETV TDF therapy.This...
BackgroundIt is unclear whether direct-acting antivirals (DAAs) treatment improves the disease burden in hepatitis C virus (HCV) infection. This study aimed to investigate effect of DAA on reduction patients with HCV infection using individual participant data.MethodsThis nationwide multicentre retrospective cohort recruited from 29 tertiary institutions South Korea. The data collection was done medical records each institution. included untreated and DAAs-treated excluded those a history...
Although sorafenib is recommended for patients with advanced hepatocellular carcinoma (HCC), a substantial portion of HCC in Asia are still treated other treatments, mainly due to the prohibitive cost sorafenib. We aimed evaluate clinical outcome and those modalities single-center cohort.We reviewed medical records two groups consecutive HCC, according applied treatment modalities, between January 2007 September 2009 as follows: who received 6 weeks or more (n=123) were one including...
This study compared the clinical outcomes between endoscopic and radiologic placement of self-expandable metal stent (SEMS) in patients with malignant colorectal obstruction.In total, 111 were retrospectively enrolled this January 2003 June 2011 at Seoul National University Boramae Hospital. Technical success rates, complication patency using an (n=73) or (n=38) method during SEMS procedure.The technical rate was higher than (100% [73/73] vs. 92.1% [35/38], respectively; p=0.038). In...