A5077130772- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Hepatitis C virus research
- Acute Myocardial Infarction Research
- Gastric Cancer Management and Outcomes
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Liver Disease and Transplantation
- Antiplatelet Therapy and Cardiovascular Diseases
- Statistical Methods and Inference
- Colorectal Cancer Screening and Detection
- Statistical Methods and Bayesian Inference
- Esophageal and GI Pathology
- Statistical Methods in Clinical Trials
- Ophthalmology and Visual Impairment Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Gastrointestinal Tumor Research and Treatment
- Cardiac Valve Diseases and Treatments
- Esophageal Cancer Research and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
Korea University
2021-2025
University of Ulsan
2012-2022
Ulsan College
2012-2022
Ulsan University Hospital
2013-2022
Gachon University
2015-2021
Asan Medical Center
2012-2018
Creative Research Enterprises (United States)
2017
Pusan National University
2017
Pusan National University Yangsan Hospital
2017
Catholic University of Korea
2014-2015
Background: Procedural results for percutaneous coronary intervention (PCI) in vessels with chronic total occlusion (CTO) have improved recent years, and PCI strategies moved toward more complete revascularization liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies small clinical trials. Methods: In this open-label, multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned receive either 1 2 strategies: or no the...
<h3>Importance</h3> Current recommendations for patients with cirrhosis are to undergo surveillance hepatocellular carcinoma (HCC) ultrasonography (US) every 6 months. However, the sensitivity of US screening detect early-stage HCC is suboptimal. Magnetic resonance imaging (MRI) liver-specific contrast may additional HCCs missed by in high-risk cirrhosis. <h3>Objective</h3> To compare detection rate and MRI who at high risk HCC. <h3>Design, Setting, Participants</h3> A prospective study 407...
The risks and benefits of long-term dual antiplatelet therapy remain unclear.This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers Korea. In total, 5045 patients who received drug-eluting stents were free major adverse cardiovascular events bleeding for at least 12 months after stent placement enrolled between July 2007 2011. Patients to receive aspirin alone (n=2514) or clopidogrel plus (n=2531). primary end point a composite death...
Objective High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients chronic hepatitis B (CHB). Although the immune-tolerant (IT) phase is characterised by circulating levels, it remains unknown whether antiviral treatment reduces HCC mortality. Design This historical cohort study included HBeAg-positive CHB (≥20 000 IU/mL) no evidence at a tertiary referral hospital Korea from 2000 to 2013. The clinical outcomes 413 untreated...
In Brief Objective: To develop clinical predictive nomograms generating per-patient numerical probabilities of postoperative recurrence-free and overall survival at specific times. Background: The prognosis after surgical resection is diverse in patients with early-stage hepatocellular carcinoma (HCC). Methods: a retrospective review, we evaluated data from 1085 mostly newly diagnosed HCC who were subsequently treated by curative resection. We randomly divided the subjects into derivation (n...
We aimed to determine the surveillance performance of alpha‐fetoprotein (AFP), lectin‐reactive AFP (AFP‐L3), des‐gamma‐carboxy prothrombin (DCP), and their combinations for early detection hepatocellular carcinoma (HCC) by using prospectively collected longitudinal samples in patients at risk. Among 689 with cirrhosis and/or chronic hepatitis B who participated four prospective studies, 42 HCC cases were diagnosed, selected, matched 168 controls age, sex, etiology, cirrhosis, duration...
ABSTRACT Background and Aims Real‐world data on the variceal bleeding (VB) risk in patients receiving atezolizumab–bevacizumab (Atezo–Bev) treatment remain limited. This study aimed to assess of VB identify factors with advanced hepatocellular carcinoma (HCC) Atezo–Bev treatment. Methods retrospective included 640 HCC who underwent endoscopy before at two hospitals Korea. The primary outcome was occurrence VB, non‐VB events considered as competing events. Results Of patients, mean age 61.3...
Background & AimsLittle is known about whether the antiviral agent entecavir more effective than a less potent drug, lamivudine, in reducing risk of death and hepatocellular carcinoma (HCC) patients with chronic hepatitis B.MethodsWe performed retrospective analysis data from 5374 consecutive adult B, treated (n = 2000) or lamivudine 3374), at tertiary referral hospital Seoul, Korea, November 1, 1999, through December 31, 2011. Data were collected for up to 6 years analyzed by multivariable...
Background & AimsHepatocellular carcinoma (HCC) has a high rate of intrahepatic recurrence after curative treatment, possibly because metastases are not always identified before treatment. Magnetic resonance (MR) imaging with liver-specific contrast agent, gadoxetic acid, can detect small HCCs levels sensitivity. We investigated whether MR acid increases overall and recurrence-free survival patients initially assessed by computed tomography (CT).MethodsWe performed retrospective study data...
Most mortalities from liver disease and cancer worldwide are attributable to hepatitis B virus (HBV) C virus. Despite remarkable advances in the treatment of HBV over past decades, limited population‐level data available regarding its impact on burden cancer. Mortality were obtained national death certificate database Korea, an HBV‐endemic country, between 1999 2013, analyzed by Joinpoint analysis. For disease, number annual deaths decreased 62.3% (95% confidence interval [CI], 62.0‐62.6),...
Summary Background It remains unknown whether antiviral treatment for HBeAg‐negative chronic hepatitis B (CHB) patients having high viral loads without significant elevation of alanine aminotransferase (ALT) levels would reduce the risks clinical events. Aim To compare outcomes load CHB untreated normal or mildly elevated ALT vs those treated ≥ 2 upper limit (ULN). Methods This historical cohort study included 5414 cirrhosis at a tertiary hospital in Korea from 2000 to 2013. Inactive phase...
Studies have shown a higher risk of hepatocellular carcinoma (HCC) with baseline serum hepatitis B virus (HBV) DNA levels in chronic (CHB) patients. However, the association between very high HBV (>6 log10 IU/mL) and HCC remains unclear, especially middle-aged old HBeAg-positive patients.To identify broad-range risk.We conducted historical cohort study Korea involving 6949 non-cirrhotic, treatment-naïve CHB patients alanine aminotransferase (ALT) <2× upper limit normal for >1 year. was >6...
We evaluated the impact of routine use fractional flow reserve (FFR) on practice and outcomes percutaneous coronary intervention (PCI).Between January 2008 December 2011, rate FFR during PCI increased from 1.9 to 50.7% after introduction (P < 0.001). A total 5097 patients (2699 before 2398 FFR) underwent at an academic hospital in Korea; those, stent implantation was deferred 475 patients. used propensity score (PS) matching compare rates primary endpoint [death, myocardial infarction (MI),...
Summary Background Spontaneous portosystemic shunt ( SPSS ) is a frequent cause of recurrent hepatic encephalopathy HE in patients with cirrhosis. Aim To assess the effectiveness and optimal candidate selection for embolisation , treatment Methods This retrospective cohort study compared 17 who achieved complete occlusion by angiographic control patients. Results Most baseline characteristics were similar two groups. The 2‐year recurrence rate was significantly lower than group (39.9% vs....
Early recurrence (ER) of atrial tachyarrhythmias during the first 3 months (blanking period) after fibrillation ablation can be highly symptomatic, often requiring emergency treatment. Short-term steroid therapy may suppress ER blanking period.We prospectively enrolled 138 patients who were randomly assigned to 2 groups (steroid group and control group). An intravenous bolus 0.5 mg/kg methylprednisolone for days followed by 12 mg daily oral 4 was given patients. The primary end point period...
BACKGROUND. It is unclear whether the level of serum hepatitis B virus (HBV) DNA at baseline affects on-treatment risk hepatocellular carcinoma (HCC) in e antigen–positive (HBeAg-positive), noncirrhotic patients with chronic (CHB).
Serum hepatitis B virus (HBV) DNA levels and non-invasive liver fibrosis scores are significantly associated with hepatocellular carcinoma (HCC) risk in chronic (CHB) patients. Nonetheless, the relationship between HBV is unclear. A historical cohort comprising 6,949 non-cirrhotic Korean CHB patients without significant alanine aminotransferase elevation was investigated. The association of aspartate to platelet ratio index (APRI) (FIB)-4 score at baseline analyzed using general linear...
In Epstein-Barr virus (EBV)-infected gastric carcinoma, EBV-encoded BARF1 has been hypothesized to function as an oncogene. To evaluate cellular changes induced by BARF1, we isolated the full-length gene from carcinoma cells that were naturally infected with EBV and transfected into EBV-negative cells. protein was primarily secreted culture supernatant only marginally detectable within Compared containing empty vector, BARF1-expressing exhibited increased cell proliferation (P < 0.05). There...