Patients with hepatocellular carcinoma showing macroscopic vascular invasion have a poor prognosis. Sorafenib is the sole treatment option for these patients, unsatisfactory response and survival benefit. Combined transarterial chemoembolization (TACE) plus external beam radiotherapy (RT) has shown promising results patients in observational studies.To evaluate efficacy safety of TACE RT compared sorafenib invasion.In this randomized, open-label clinical trial conducted at an academic...

<h3>Importance</h3> Current recommendations for patients with cirrhosis are to undergo surveillance hepatocellular carcinoma (HCC) ultrasonography (US) every 6 months. However, the sensitivity of US screening detect early-stage HCC is suboptimal. Magnetic resonance imaging (MRI) liver-specific contrast may additional HCCs missed by in high-risk cirrhosis. <h3>Objective</h3> To compare detection rate and MRI who at high risk HCC. <h3>Design, Setting, Participants</h3> A prospective study 407...

Background & AimsHepatocellular carcinoma (HCC) has a high rate of intrahepatic recurrence after curative treatment, possibly because metastases are not always identified before treatment. Magnetic resonance (MR) imaging with liver-specific contrast agent, gadoxetic acid, can detect small HCCs levels sensitivity. We investigated whether MR acid increases overall and recurrence-free survival patients initially assessed by computed tomography (CT).MethodsWe performed retrospective study data...

Purpose To develop and validate a radiomics-based model for staging liver fibrosis by using gadoxetic acid–enhanced hepatobiliary phase MRI. Materials Methods In this retrospective study, 436 patients (mean age, 51 years; age range, 18–86 319 men [mean years]; 117 women 50 18–79 years]) with pathologic analysis–proven who underwent MRI from June 2015 to December 2016 were randomized in three-to-one ratio into development (n = 329) test 107) cohorts, respectively. the cohort, was developed...

The aim of this study was to validate the Liver Imaging Reporting and Data System (LI-RADS) v2014 category 4 (LR-4) 5 (LR-5) criteria on gadoxetate disodium-enhanced magnetic resonance imaging (MRI) in patients with chronic liver disease.Between January December 2012, 300 disease who had hepatic nodules 3.0 cm or smaller at surveillance ultrasonography MRI were included. LI-RADS retrospectively assigned each nodule MRI. Final diagnosis assessed using pathologic only (operation core-needle...

Purpose To evaluate gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings of combined hepatocellular cholangiocarcinoma (cHCC-CC) with special emphasis on correlation MRI histopathologic tumor characteristics and survival outcomes after curative surgery. Materials Methods Our Institutional Review Board approved this study, a waiver informed consent. For 82 patients (64 men, 18 women; mean age, 54.0 years; age range, 30–81) surgically confirmed cHCC-CCs, we evaluated clinical...

// Chae Hwa Kwon 1 , Hye Ji Park Yu Ri Choi Ahrong Kim Won Jin Chung Su Hwang So Jung Lee Chang In 2 Tae Yong Jeon Dae Hwan Gwang Ha 3 and Do Youn Department of Pathology, Pusan National University Hospital School Medicine, BioMedical Research Institute, Hospital, Seo-Gu, Busan, Korea Surgery, Internal Correspondence to: Park, email: Keywords : stomach, adenocarcinoma, prognosis, PSMB8, PBK Received August 10, 2015 Accepted February 05, 2016 Published 15, Abstract Gastric adenocarcinoma is a...

Abstract Background &amp; Aims We aimed to compare the performance of gadoxetic acid‐enhanced abbreviated MRI (AMRI)‐based surveillance and ultrasound‐only in high‐risk patients for hepatocellular carcinoma (HCC). Methods Prospectively recruited (&gt;5% annual risk HCC) who underwent one three rounds complete (CMRI) ultrasound at 6‐months intervals were retrospectively analysed. AMRI consisted diffusion‐weighted, T2‐weighted, hepatobiliary phase imaging. The sensitivity, specificity,...

To evaluate the utility of tardus parvus waveform hepatic artery at Doppler ultrasonography (US) in diagnosis arterial stenosis liver transplant (LT) recipients and determine whether accuracy such a is enhanced by including an optimal peak systolic velocity (PSV) cutoff.This retrospective study was institutional review board approved; requirement for informed consent waived. The authors identified 361 LT (267 male, 94 female) who underwent US either computed tomography (CT) or angiography,...

Background The 2017 version of the Liver Imaging Reporting and Data System (LI-RADS) recently included standardized interpretation, reporting, management guidelines for US (US LI-RADS); however, this system has not yet been validated. Purpose To evaluate diagnostic performance LI-RADS detecting hepatocellular carcinoma (HCC) in participants at high risk to determine clinical factors associated with a poor visualization score. Materials Methods This study 407 prospectively recruited (mean...

Regorafenib and nivolumab are drugs approved for second‐line treatment of patients with hepatocellular carcinoma (HCC) after sorafenib failure. However, the effectiveness regorafenib following has not been directly compared. This study retrospectively evaluated 373 HCC who were treated (n = 223) or 150) failure between July 2017 February 2019. Progression‐free survival (PFS; hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.69‐1.06; P 0.150), time to progression (TTP; HR, 0.95; CI,...

Salivary duct carcinoma (SDC) is a rare malignancy of high-grade pathological type. We evaluated clinical outcomes and prognostic factors in 35 patients with SDC treated post-operatively adjuvant radiation.We retrospectively assessed overall survival, locoregional control disease-free survival the major salivary glands who underwent surgery were subsequently radiotherapy. The included gender, age, symptom duration, tumour site, size, TNM classification, following features: perineural...

According to the increasing need for accurate staging of hepatic fibrosis, ultrasound (US) elastography techniques have evolved significantly over past two decades. Currently, US is increasingly used in clinical practice. Previously published studies demonstrated excellent diagnostic performance detection and liver fibrosis. Although may seem easy perform interpret, there are many technical factors which can affect results elastography. Therefore, clinicians who involved with should be aware...

The purpose of this study is to describe the imaging characteristics hepatic angiomyolipoma (AML) on gadoxetic acid-enhanced MRI and identify features that are helpful for differentiating it from hepatocellular carcinoma (HCC) in a noncirrhotic liver.We retrospectively identified 18 patients with pathologically proven AMLs who had undergone between 2008 2012. We randomly chose 36 liver single HCC diagnosed radiologically during same period. None HCCs was fibrolamellar variant. Two readers...

Objective Psychosocial dysfunction was a nettlesome of schizophrenia even in their prodromal phase as well first episode and its relations with psychopathology were not determined. The aim the present study to examine whether social role function impairment found ultra-high risk for psychosis (UHR) individuals first-episode patients explore psychopathology. Methods Thirty-seven normal controls, 63 UHR participants 28 young, recruited. functioning examined by using Global function: Social...

PD-L1 expression levels determined by immunostaining are known to be related the survival rate and prognosis of patients with various types cancers, as well therapeutic response immune checkpoint inhibitors. Recently, U.S. Food Drug Administration approved an inhibitor for treatment non-small cell lung cancer along clones used predict resulting response. In this study, we performed tissue microarrays from ovarian epithelial using SP263, clone, examined effect on prognosis.Tissue were...

To evaluate the value of intravoxel incoherent motion (IVIM) parameters for characterizing focal hepatic lesions, and to assess correlation between IVIM arterial nodule enhancement.We retrospectively evaluated 161 lesions (91 hepatocellular carcinomas [HCCs], 27 intrahepatic cholangiocarcinomas [IHCCs], 20 hemangiomas, 9 combined hepatocellular-cholangiocarcinomas, metastases, 5 other tumors) in patients (105 men 56 women; mean age, 56.4 years). Diffusion-weighted imaging was performed using...

Objective: To retrospectively evaluate the safety and efficacy of percutaneous radiofrequency ablation (RFA) in patients with metachronous hepatic metastases arising from pancreatic adenocarcinoma who had previously received curative surgery.Materials Methods: Between 2002 2017, RFA was performed on 94 (median diameter, 1.5 cm) cancer 60 (mean age, 60.5 years).Patients were included if they fewer than five metastases, a maximum tumor diameter ≤ 5 cm, disease confined to liver or stable...