A5065717188- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gallbladder and Bile Duct Disorders
- Pluripotent Stem Cells Research
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Mesenchymal stem cell research
- Biliary and Gastrointestinal Fistulas
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystallization and Solubility Studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Abdominal vascular conditions and treatments
- TGF-β signaling in diseases
- Medical Device Sterilization and Disinfection
Korea University
2012-2024
Ansan University
2015-2024
Korea University Medical Center
2022
Johns Hopkins Medicine
2014-2021
Johns Hopkins University
2014-2021
Institute of Pathology Celle
2020
Catholic University of Korea
2017-2019
University of Ulsan
2016-2017
Asan Medical Center
2016-2017
Ulsan College
2016-2017
Dopamine receptor subtypes D1 and D2, many other seven-transmembrane receptors including adenosine A2A, are colocalized in striatum of brain. These stimulate or inhibit adenylyl cyclases (ACs) to produce distinct physiological pharmacological responses interact with each synergistically antagonistically at various levels. The identity the AC isoform that is coupled these receptors, however, remains unknown. To investigate vivo role type 5 cyclase (AC5), which preferentially expressed...
Occupation ratio and fatty infiltration are important parameters for evaluating patients with rotator cuff tears. We analyzed the occupation using a deep-learning framework studied of supraspinatus muscle an automated region-based Otsu thresholding technique. To calculate amount The mean Dice similarity coefficient, accuracy, sensitivity, specificity, relative area difference segmented lesion, measuring clinician assessment that deep neural network, were 0.97, 99.84, 96.89, 99.92, 0.07,...
Juhyun Jeong, Suk Keu Yeom, In Young Choi, Sang Hoon Cha, Ji Sung Han, Chang Hee Lee, Deuk Jae Sung, Jung-Woo Hyun Bae, Hangseok InSeong Kim, Thomas Benkert, Elisabeth Weiland
Duchenne muscular dystrophy (DMD) is the most common dystrophy. In present study, when human induced pluripotent stem cells (hiPSCs) were differentiated into myoblasts, myoblasts derived from DMD patient hiPSCs (DMD hiPSC–derived myoblasts) exhibited an identifiable DMD-relevant phenotype: myogenic fusion deficiency. Based on this model, we developed a myoblast screening platform employing high-content imaging (BD Pathway 855) approach to generate parameters describing morphological as well...
To evaluate the value of intravoxel incoherent motion (IVIM) parameters for characterizing focal hepatic lesions, and to assess correlation between IVIM arterial nodule enhancement.We retrospectively evaluated 161 lesions (91 hepatocellular carcinomas [HCCs], 27 intrahepatic cholangiocarcinomas [IHCCs], 20 hemangiomas, 9 combined hepatocellular-cholangiocarcinomas, metastases, 5 other tumors) in patients (105 men 56 women; mean age, 56.4 years). Diffusion-weighted imaging was performed using...
Objective: To investigate the diagnostic yield and accuracy of CT enterography (CTE) for early (< 12 postoperative months) surveillance anastomotic recurrence after bowel resection Crohn's disease (CD). Materials Methods:We analyzed 88 adults (60 males 28 females; mean age, 31.4 ± 9.6 years) who underwent surgery CD that created ileocolic anastomosis without enteric stoma, CTE recurrence/aggravation within post-operative months.The activity index (CDAI) at time was < 150 (i.e., clinically...
Abstract Background Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies following injury. Here, we investigate the therapeutic effect NCSC therapy associated changes in spinal cord a sciatic transection (SNT) model. Methods Complex gap injuries rats were repaired with cell-free cell-laden scaffolds 12 weeks (scaffold groups,...
This study was done to evaluate the stemness of human mesenchymal stem cells (hMSCs) derived from placenta according development stage and compare results those adult bone marrow (BM). Based on source hMSCs, three groups were defined: group I included term placentas, II first-trimester III BM samples. The evaluated by proliferation capacity, immunophenotypic expression, mesoderm differentiation, expression pluripotency markers including telomerase activity. cumulative population doubling,...
B-cell activating factor of the tumor necrosis family (BAFF) and a proliferation-inducing ligand (APRIL) regulate survival proliferation B cells. Thus association elevated serum levels BAFF APRIL with worse prognosis has been suggested in lymphoid malignancies. However, prognostic relevance is unknown patients treated rituximab, monoclonal antibody targeting depletion.We measured by enzyme-linked immunosorbent assay 66 newly diagnosed as diffuse large lymphoma (DLBCL). All were...
In the culture system using human feeder cells, mechanism through which these cells support undifferentiated growth of embryonic stem (ESCs) has not been well investigated. Here, we explored mechanisms 3 kinds including placental from chorionic plate, bone marrow stromal and foreskin fibroblasts. First, determined that 2 each (H1 HSF6) mouse (D3 CE3) ESCs was possible in all cell types tested (human fibroblasts), without need for exogenous cytokine supplementation basic fibroblast factor...
In order for human embryonic stem cells (hESCs) to be cultured on mouse fibroblast (MEFs) feeder cells, continuous basic growth factor (bFGF) supplementation is required. However, the role of bFGF in a culture system using human-derived has not been evaluated until now. this study, we propagated widely used hESC lines, H1 and HSF6, placenta-derived (HPCs) without exogenous supplementation, were able propagate hESCs HPC feeders up 50 passages. The absence media did interrupt undifferentiated...
To compare the image quality of CT obtained using a deep learning-based reconstruction (DLIR) engine with images adaptive statistical iterative reconstruction-V (AV).Using phantom, noise power spectrum (NPS) and task-based transfer function (TTF) were measured in different reconstructions (filtered back projection [FBP], AV30, 50, 100, DLIR-L, M, H) at multiple doses. One hundred twenty abdominal CTs 30% dose reduction processed AV50, H. Objective subjective analyses performed.The NPS peak...
<i>Background:</i>Tissue-invading helminth parasites secrete a large amount of cysteine proteases that may play critical roles in tissue invasion and immune modulation. However, excretory-secretory products (ESP) secreted by <i>Paragonimus westermani</i> the activation death microglial cells brain are poorly understood. <i>Objectives:</i> In present study, we investigated whether ESP could regulate nitric oxide (NO) production viability....