A5050677558- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Health and Wellbeing Research
- Mental Health Treatment and Access
- Health and Well-being Studies
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
- Cell death mechanisms and regulation
- Education and Learning Interventions
- Physical Activity and Health
- Urban Green Space and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Electrolyte and hormonal disorders
- Electroconvulsive Therapy Studies
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Workplace Health and Well-being
- Technology Use by Older Adults
Ajou University
2014-2024
Health Insurance Review and Assessment Service
2015
Inha University
2015
Asan Medical Center
2015
Ajou University Hospital
2015
Jacobson Holman (United States)
2015
Samsung (South Korea)
2013
Yonsei University
2010
University of Illinois Urbana-Champaign
2005
University of Illinois Chicago
2005
Background We examined the longitudinal association between participation in individual or combinations of physical, social, and religious activity risk depression elderly. Methods Elderly subjects aged ≥60 years who completed Living Profiles Older People Survey Korea (n = 6,647) were included. The baseline assessment, Wave 1, was conducted 2008, a follow-up 2, 2011. defined frequent physical as ≥3 times weekly (at least 30 minutes per activity). Frequent social ≥1 weekly. primary outcome at...
Dopamine receptor subtypes D1 and D2, many other seven-transmembrane receptors including adenosine A2A, are colocalized in striatum of brain. These stimulate or inhibit adenylyl cyclases (ACs) to produce distinct physiological pharmacological responses interact with each synergistically antagonistically at various levels. The identity the AC isoform that is coupled these receptors, however, remains unknown. To investigate vivo role type 5 cyclase (AC5), which preferentially expressed...
The polygenic nature of complex psychiatric disorders suggests a common pathway that may be involved in the down-regulation multiple genes through an epigenetic mechanism. To investigate role methylation down-regulating expression mRNAs associated with schizophrenia phenotype, we have adopted cell-culture model amenable to this line investigation. We administered methionine (2 mM) primary cultures cortical neurons prepared from embryonic day 16 mice and show treatment down-regulated reelin...
We examined effects of two insulin-like growth factors, insulin and factor-I (IGF-I), against apoptosis, excitotoxicity, free radical neurotoxicity in cortical cell cultures. Like IGF-I, attenuated serum deprivation-induced neuronal apoptosis a dose-dependent manner at 10-100 ng/mL. The anti-apoptosis effect deprivation disappeared by addition broad protein kinase inhibitor, staurosporine, but not calphostin C, selective C inhibitor. Addition PD98059, mitogen-activated (MAPKK) blocked...
The Fas pathway and oxidative stress mediate neuronal death in stroke may contribute to neurodegenerative disease. We tested the hypothesis that these two factors synergistically produce spinal motor neuron degeneration amyotrophic lateral sclerosis (ALS). Levels of reactive oxygen species were increased neurons from ALS mice compared with wild-type at age 10 weeks, before symptom onset. proapoptotic proteins Fas, Fas-associated domain, caspase 8, 3 also elevated. Oral administration...
Background and Purpose: While providing medical services, hospitals generate many data about patients. Such could contribute to better treatments once their associations or patterns have been identified. With properly analyzed data, traditional knowledge at an individual level be further extended broader populations. This comprehensive study was performed demonstrate the effectiveness of light using accumulated over 15 years. Methods: Patients who were admitted window door side a six-bedded...
<b><i>Background:</i></b> A healthy lifestyle may protect against cognitive decline. We examined outcomes in elderly individuals after 18 months of a five-group intervention program consisting various modalities to prevent <b><i>Methods:</i></b> conducted cluster randomized controlled trial assessing 460 community-dwelling aged 60 years and older geriatric community mental health center Suwon, Republic Korea, between 2008 2010. developed an...
Abstract: We examined patterns and mechanisms of cell death inducedby haloperidol. Cortical cultures exposed to 10‐100 μ M haloperidol for 24 h underwent neuronal without injuring glia. Thedegenerating neurons showed hallmarks apoptosis, featuring bodyshrinkage, nuclear chromatin condensation aggregation, membranedisintegration with intact plasma membrane, prominent internucleosomal DNAfragmentation. Neither glutamate antagonists nor antioxidants prevented thehaloperidol‐induced apoptosis....
The goal of the present study was to examine neuroprotective and functional significance targeting both N-methyl-d-aspartate (NMDA) receptor–mediated excitotoxicity oxidative stress using a dual-acting compound, Neu2000, in rat model moderate spinal cord injury (SCI). An initial set experiments conducted uninjured rats pharmacokinetic profile Neu2000 following intraperitoneal intravenous administration. A second experiment measured free radical production mitochondria isolated from sham or...
We examined the possibility that neuroprotective effects of Li<sup>+</sup> would depend upon patterns neuronal death, apoptosis versus necrosis, and whether Ca<sup>2+</sup> as well phosphoinositide 3-kinase (PI3-K) mediate effect Li<sup>+</sup>. Cortical neurons treated with showed marked increase in [Ca<sup>2+</sup>]<sub>i</sub> within 2 min. Addition BAPTA-acetoxymethyl ester, a selective chelator, abrogated antiapoptotic PI3-K was activated rapidly 1 min after exposure to Li<sup>+</sup>,...
Objective: Postoperative delirium after cardiac surgery is associated with many consequences such as poorer functional recovery, more frequent postoperative complications, higher mortality, increased length of hospital stay, and costs. The aim this study was to evaluate the efficacy perioperative psycho-educational intervention in preventing post patients. Method: We conducted a comparative retrospective between 49 patients who had received 46 standard care. primary outcome incidence...
Background/Objective: We aimed to compare the risk of mortality in patients with early-onset Alzheimer’s disease (EOAD) versus those late-onset AD (LOAD) using a large number study subjects. applied propensity score matching (PSM) minimize confounding biases comparison between EOAD and LOAD. Methods: obtained data from elderly Korean subjects ( n = 3,611) at baseline CREDOS cohort study, which was conducted November 2005 July 2013. PSM reduce bias due variables related survival AD. The risks...
Background and Aims Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases from damage resulting cerebral ischemia. In this study, we assessed association between plasma HSP 70/27 levels cognitive decline. Methods Among participants in community-based cohort study dementia called Gwangju Dementia Mild Cognitive Impairment Study, subjects without impairment at baseline, who then either remained...
There have been a few case reports that clozapine, an atypical antipsychotic, caused acute renal failure of interstitial type. Here we report 38-year-old Korean male patient with treatment-resistant bipolar I disorder who developed after the initiation treatment clozapine. We describe clinical and laboratory findings discuss measures for early detection this life threating condition. Within our knowledge, is first clozapine-induced in South Korea. Keywords: Clozapine, Acute failure,...
Background: In keeping with increasing interest in dementia, few recent studies suggest that clinical course of mild cognitive impairment vary across different hospital-based subjects showing higher rates conversion than community-based subjects. Objective: The main objective the present study was to assess whether or reversion differ according recruitment source. Methods: baseline comprised patients who were diagnosed GDEMCIS CREDOS. two had nearly same protocol and performed over a similar...
Objective The impact of the government-initiated senior employment program (GSEP) on geriatric depressive symptoms is underexplored. Unearthing this connection could facilitate planning future programs and depression interventions. In present study, we aimed to elucidate possible association between GSEP in older adults.Methods This study employed data from 9,287 participants aged 65 or older, obtained 2020 Living Profiles Older People Survey. We measured using Korean version 15-item...