To develop an efficient brain-computer interface (BCI) system, electroencephalography (EEG) measures neuronal activities in different brain regions through electrodes. Many EEG-based motor imagery (MI) studies do not make full use of network topology. In this paper, a deep learning framework based on modified graph convolution neural (M-GCN) is proposed, which temporal-frequency processing performed the data S-transform (MST) to improve decoding performance original EEG signals types MI...

To assess whether the clinical efficacy of a therapeutic protocol using surface neuromuscular electrical stimulation (sNMES) on patients with post-stroke dysphagia (PSD) is superior to that without sNMES, and swallowing functional outcome different regards electrode placement patients' skin neck.Thirty PSD were randomly allocated into treatment group A (TGA), B (TGB) control according random number table. The three groups all received traditional therapy (TDT) other general rehabilitation...

Reduced knee flexion is a leading feature of post-stroke gait, but the causes have not been well understood. The purpose this study was to investigate relationship between and lower-limb muscle activation within stance-to-swing phases gait cycle in hemiplegic patients. Ten stroke patients 10 age- gender-matched healthy subjects participated experiment. kinematic signals surface electromyography (sEMG) left right rectus femoris (RF), biceps (BF) lateral gastrocnemius (GS) were recorded during...

Abstract Background Middle-aged and older adults with physical disabilities exhibit more common severe depressive symptoms than those without disabilities. Such can greatly affect the mental health life expectancy of middle-aged persons Method This study selected 2015 2018 data from China Longitudinal Study Health Retirement. After analyzing effect age on depression, we used whether were depressed as dependent variable included a total 24 predictor variables, including demographic factors,...

Objectives To identify potential treatment targets for spinal cord injury (SCI)-related neuropathic pain (NP) by analysing the differences in electroencephalogram (EEG) and brain network connections among SCI patients with NP or numbness. Participants methods The EEG signals during rest, as well left- right-hand feet motor imagination (MI), were recorded. power spectral density (PSD) of θ (4–8 Hz), α (8–12 β (13–30 Hz) bands was calculated applying Continuous Wavelet Transform (CWT) Modified...

The aim of this meta-analysis was to evaluate the clinical efficacy constraint-induced movement therapy in acute and sub-acute stroke.The key words were stroke, cerebrovascular accident, therapy, forced use, randomized controlled trial. databases, including China National Knowledge Infrastructure, WanFang, Weipu Information Resources System, Chinese Biomedical Literature Database, PubMed, Medline, Embase, Cochrane Central Register Controlled Trials, Database Systematic Reviews, searched for...

Abstract Background Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies following injury. Here, we investigate the therapeutic effect NCSC therapy associated changes in spinal cord a sciatic transection (SNT) model. Methods Complex gap injuries rats were repaired with cell-free cell-laden scaffolds 12 weeks (scaffold groups,...

Objective: To investigate whether full-movement neuromuscular electrical stimulation, which can generate full range of movement, reduces spasticity and/or improves motor function more effectively than control, sensory threshold—neuromuscular and stimulation in sub-acute stroke patients. Design: A randomized, single-blind, controlled study. Setting: Physical therapy room functional assessment room. Participants: total 72 adult patients with post-stroke hemiplegia plantar flexor spasticity....

Neuroinflammation is a major contributor to neuropathic pain. Receptor interacting serine/threonine kinase 3 (RIP3) senses cellular stress, promotes inflammatory responses and activates c-Jun N-terminal (JNK) signaling. Here, we assessed the involvement of RIP3-induced JNK signaling in chronic constriction injury (CCI)-induced We found that RIP3 inhibitors (GSK'872) (SP600125) not only alleviated radiant heat response mechanical allodynia CCI rats, but also reduced factor levels lumbar...

This study focused on the relationship between extracellular-regulated kinase (ERK) and obesity-induced increases in neuropathic pain. We fed rats a high-fat diet to establish obesity model, were given surgery chronic compression of dorsal root ganglia (CCD) model. U0126 was applied inhibit ERK, metformin or 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) cause AMP-activated protein (AMPK) activation. Paw withdrawal mechanical threshold (PWMT) calculated indicate level The data...

Neuropathic pain (NP), which results from injury or lesion of the somatosensory nervous system, is intimately associated with glial cells. The roles microglia and astrocytes in NP have been broadly described, while studies on oligodendrocytes largely focused axonal myelination. mechanisms their interactions other cells development remain uncertain.

Abstract Background Knee osteoarthritis (KOA) is a multifactorial, slow-progressing, non-inflammatory degenerative disease primarily affecting synovial joints. It usually induced by advanced age and/or trauma and eventually leads to irreversible destruction of articular cartilage other tissues the joint. Current research on KOA progression has limited clinical application significance. In this study, we constructed prediction model for based multiple clinically relevant factors provide...

Adaptor molecule downstream of kinase-3 (DOK3) is a vital regulator innate immune responses in macrophages and B cells, G-protein-coupled receptor 84 (GPR84) significant mediating the biosynthesis maintenance inflammatory mediators that are induced by neuropathic pain microglia.In present study, we determined role DOK3 activating microglia-induced investigated underlying mechanisms associated with GPR84.We found knockdown microglial cells dramatically reduced levels factors, uncovered...

Transplantation of neural stem cells (NSCs) is one the most promising treatments for spinal cord injury (SCI). However, limited survival transplanted NSCs reduces their therapeutic effects. The aim present study was to examine whether a co-transplantation olfactory ensheathing (OECs) may enhance and improve beneficial effects in rats with SCI, as well investigate potential mechanisms underlying such efficacies. Co-transplantation OECs used treat SCI. Sympathetic nerve function determined by...

Transient receptor potential vanilloid 4 (TRPV4)-mediated astrocyte activation is critical to neuropathic pain. Pregabalin, a widely used drug treat chronic pain, reported lower the intracellular calcium level. However, molecular mechanism by which pregabalin decreases level remains unknown. Purinergic P2Y2 receptor-a member of G protein-coupled (GPCR) family-regulates calcium-related signal transduction in activation. We investigated whether involved pharmacological effects on...

This study investigated the effects of fingertip tactile sensitivity on structural variability thumb and index finger forces during stable precision grip. Thirty right-handed healthy subjects participated in experiment. Transient perturbation afferents was achieved by wrapping up distal pads or with transparent polyethylene films. The time-dependent structure each digit force interdigit correlation were examined detrended fluctuation analysis (DFA) cross-correlation (DCCA), respectively....

Neuropathic pain (NP) is caused by primary or secondary impairment of the peripheral central nervous systems. Its etiology complex and involves abnormal patterns gene expression pathway activation. Using bioinformatics analysis, we aimed to identify NP-associated changes in genes pathways L4 L5 dorsal root ganglia (DRG) a rat model NP induced chronic compression DRG (CCD). Genome-wide transcriptional analyses were used elucidate molecular mechanisms underlying NP. We screened differentially...

Objective The objective of this study was to analyze the changes in connectivity between motor imagery (MI) and execution (ME) premotor area (PMA) primary cortex (MA) brain, aiming explore suitable forms treatment potential therapeutic targets. Methods Twenty-three inpatients with stroke were selected, 21 right-handed healthy individuals recruited. EEG signal during hand MI ME (synergy isolated movements) recorded. Correlations functional brain areas compared. Results PMA MA significantly...