A5101142403- Perovskite Materials and Applications
- Polysaccharides and Plant Cell Walls
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Microbial Natural Products and Biosynthesis
- Enzyme Production and Characterization
- Fungal Biology and Applications
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Biofuel production and bioconversion
- EEG and Brain-Computer Interfaces
- Plant nutrient uptake and metabolism
- MicroRNA in disease regulation
- Phytochemical Studies and Bioactivities
- Microbial Metabolic Engineering and Bioproduction
- Microbial Metabolites in Food Biotechnology
- Axon Guidance and Neuronal Signaling
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Radioactive element chemistry and processing
- Wnt/β-catenin signaling in development and cancer
- Natural Compounds in Disease Treatment
- Cancer Treatment and Pharmacology
- Biomarkers in Disease Mechanisms
- Bioactive Compounds in Plants
South China University of Technology
2023-2025
Qilu Hospital of Shandong University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
South China Institute of Collaborative Innovation
2023
Leibniz University Hannover
2019-2021
Shandong University
2020-2021
Beijing Hospital
2019
Southern Medical University
2012-2013
Circular RNAs (circRNAs) are endogenous non‑coding implicated in atherosclerosis. The aim of the present study was to explore function circRNA‑0044073 Reverse transcription quantitative polymerase chain reaction assays were used measure expression levels circRNA‑0044073, microRNA (miRNA/miR)‑107, janus kinase 1 (JAK1), signal transducer and activator 3 (STAT3), B‑cell lymphoma 2 (Bcl‑2) v‑myc avian myelocytomatosis viral oncogene homolog (c‑myc) blood cells from patients with RNA pull‑down...
Abstract Heart failure with preserved ejection fraction (HFpEF) is associated endothelial dysfunction. We have previously reported that statins prevent dysfunction through inhibition of microRNA-133a (miR-133a). This study to investigate the effects and underlying mechanisms on HFpEF. Here, we show upregulate expression a circular RNA (circRNA-RBCK1) which co-transcripted ring-B-box-coiled-coil protein interacting kinase C-1 (RBCK1) gene. Simultaneously, increase activator 2 alpha (AP-2α)...
Polymer hole transport layer plays a critical role in inverted perovskite solar cells since they can determine stability and photovoltaic performances of devices. However, conventional polymer materials, such...
C-Glycosyltransferases (CGTs) are powerful tools for the C-glycosylation of natural and unnatural products. However, CGTs able to catalyze bis-C-glycosylation very rare key amino acids which have not been uncovered. Here, we discovered a C-glycosyltransferase MiCGTb from Mangifera indica that has capacity bis-C-glycosylation. Further studies on active-site motifs revealed I152 was critical acid residue second its S60/V100/T104 residues were pivotal activity. Moreover, developed panel...
Abstract The dipole moment of hole transport materials (HTMs) plays a vital role in improving the photovoltaic performance inverted perovskite solar cells (PSCs). However, manipulating moments polymer HTMs, which have great operational and bias stability, remains challenging. In this work, HTMs with varying lengths glycol side chains, PTAC‐DEG PTAC‐TEG, are developed. Using random‐walk model extended from chain conformation, (with shorter chains) achieves higher cumulative than PTAC‐TEG....
Multifunctional theranostics play a critical role in improving the efficacy of photothermal therapy and tumor fluorescence imaging; however, they require integration complex components into single theranostic system, their response second near-infrared (NIR-II) region is constrained by wavelengths photosensitizer. To address this issue, we herein developed novel multifunctional thiazole-fused quinoxalineimide semiconducting polymer (named PQIA-BDTT), which exhibits NIR-II properties....
Exchange of 32 different sub-fragments the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by homologous fragments from desmethylbassianin (DMBS) militarinone (MILS) PKS-NRPS led to creation chimeric synthetases in which programming fidelity was altered, resulting production mixtures products with methylation patterns chain lengths. Swap KR domain...
Purmorphamine (PUR), an agonist of the Smoothened receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role hypoxic-ischemic (HI) brain injury neonatal mice remains unknown. Here we show that PUR attenuated injury, with decrease Bax/Bcl-2 ratio, inhibition caspase-3 activation. These beneficial effects were associated suppressed neuro-inflammation and oxidative stress. exerted long-term protective upon tissue loss improved neurobehavioral...
The development of vaccination and novel therapy for hepatitis C virus (HCV) has been hampered by the lack suitable small-animal models. GB B (GBV-B), closely related to HCV, causes viral in common marmosets (Callithrix jacchue jacchus) might represent an attractive surrogate model HCV infection. However, differences exist between GBV-B spite a short genetic distance two viruses. Here we report infected with HCV/GBV-B chimeras containing structural genes coding either whole core envelope...
Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, extensive applications GTs in glycosides formation limited due to their requirements expensive nucleotide diphosphate (NDP)-sugars or NDP as substrates. Here, an effort characterize flexible for glycodiversification natural products, we isolated a cDNA, designated OcUGT1 from Ornithogalum caudatum, which encoded flavonoid GT that was able catalyze trans-glycosylation...
Cerebral ischemia is a common cerebrovascular condition which often induces neuronal apoptosis, leading to brain damage. The sonic hedgehog (Shh) signaling pathway has been reported be involved in ischemic stroke, but the underlying mechanisms have not fully elucidated. In present study, we demonstrated that expressions of Shh, Ptch, and Gli-1 were significantly downregulated at 24 h following oxygen-glucose deprivation (OGD) injury neurons vitro, effects associated with increasing numbers...
Optimizing light utilization is crucial in organic photovoltaics. Understanding the intricate connection between optical properties and chemical structure of materials pivotal yet challenging this regard. Herein, over 2800 published reports with a database ≈300 non‐fullerene acceptors (NFAs) are surveyed mathematical model suitable for predicting analyzing photovoltaic established. The used to predict representative NFAs within experimental error, including four newly synthesized validate...
Developing artificial metal helicates with stimuli-responsive helicity inversion is a significant challenge in functional supramolecular chemistry. However, most reported inversions are based on the synchronous transformation of P/M conformation...
A transcriptome-guided discovery and functional identification of UGE UXE families were presented. Importantly, OcUGE1/2 OcUXE1 preliminarily revealed to be responsible for the biosynthesis anticancer polysaccharides in<italic>O. caudatum</italic>.
Objective: Vascular dementia is the second leading cause of dementia, which strongly associated with diabetes. Ectopic expression miR-133a in endothelial cells involved dysfunction Whether berberine, as a natural product Coptis chinensis, improves vascular induced by diabetes remains unknown.Methods: Diabetes and subsequent were rats injecting streptozotocin (50 mg/kg/day) for five consecutive days. The was determined fluorescence situ hybridization. learning memory evaluated step-down,...
Neuropathic pain (NP) is caused by primary or secondary impairment of the peripheral central nervous systems. Its etiology complex and involves abnormal patterns gene expression pathway activation. Using bioinformatics analysis, we aimed to identify NP-associated changes in genes pathways L4 L5 dorsal root ganglia (DRG) a rat model NP induced chronic compression DRG (CCD). Genome-wide transcriptional analyses were used elucidate molecular mechanisms underlying NP. We screened differentially...
d-Galacturonic acid (GalA) is an important component of GalA-containing polysaccharides in Ornithogalum caudatum. The incorporation GalA into these from UDP-d-galacturonic (UDP-GalA) was reasonably known. However, the cDNAs involved biosynthesis UDP-GalA were still unknown. In present investigation, one candidate UDP-d-glucuronic 4-epimerase (UGlcAE) family with three members isolated O. caudatum based on RNA-Seq data. Bioinformatics analyses indicated all isoforms, designated as...
In vitro assays of enzymes involved in the biosynthesis maleidrides from polyketides fungi were performed. The results show that are closely related to primary metabolism citric acid cycle terms stereochemical preferences, but with an expanded substrate selectivity. A key citrate synthase can react both saturated and unsaturated acyl CoA substrates give solely anti substituted citrates. This undergoes anti-dehydration afford precursor which is cyclised by ketosteroid-isomerase-like byssochlamic acid.