A5059089564- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Oxidative Organic Chemistry Reactions
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Marine Sponges and Natural Products
- Extracellular vesicles in disease
- Organic and Inorganic Chemical Reactions
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Chemical Reaction Mechanisms
- Building Energy and Comfort Optimization
- Advanced Synthetic Organic Chemistry
- Energy Efficiency and Management
- Civil and Geotechnical Engineering Research
- Synthesis of heterocyclic compounds
- Congenital Heart Disease Studies
- Cyclopropane Reaction Mechanisms
- Autophagy in Disease and Therapy
- Simulation and Modeling Applications
Southern Medical University
2019-2024
South China University of Technology
2023-2024
Guangdong Academy of Medical Sciences
2023
Guangdong Provincial People's Hospital
2023
Third Xiangya Hospital
2022
Central South University
2022
Southeast University
2021
National Tsing Hua University
2018
Temple University
2005-2010
University of Pennsylvania
2005-2010
Abstract Nowadays, cell membrane‐targeted therapy, which owns high antitumor efficacy by avoiding barriers, has received great attention. Here, a self‐delivery theranostic chimeric peptide CMP‐PpIX is designed for simultaneously targeted photodynamic therapy (PDT) of tumor and real‐time therapeutic feedback. Self‐assembled nanoparticles can effectively accumulate in enhanced permeability retention effect without additional vector. And this low background fluorescence, due to its relatively...
The instinctive protective stress responses of tumor cells hamper low-temperature photothermal therapy (LTPTT), resulting in recurrence and metastasis. rapid blood clearance low-efficiency enrichment nanomedicines also decrease the efficacy LTPTT. In this study, we fabricated coassembled agents (indocyanine green, ICG) autophagy inhibitors (chloroquine, CQ) red cell cancer hybrid membrane (RCm)-camouflaged ICGCQ@RCm nanoparticles (ICGCQ@RCm NPs) to enhance NPs exhibited prolonged drug...
Abstract The antioxidant defense system in malignant cells, which involves enzymes and molecules, is an innate barrier to photodynamic therapy (PDT). Because of the complexity endogenous mechanisms these simply inhibiting individual pathways has a limited effect on improving lethality ROS. To enhance efficacy PDT for tumor treatment, versatile nanoparticle (NP)‐based drug developed, authors call PZB NP, containing glutathione inhibitor l ‐buthionine sulfoximine (BSO) heme oxygenase 1 (HO‐1)...
Photothermal therapy (PTT) holds great potential in the field of cancer treatment due to its high specificity and low invasiveness. However, conversion efficiency, inadequate tumor accumulation, limited cellular uptake continue impede PTT effectiveness treating tumors. The present study focuses on utilization quinoxaline nanoparticles develop an organic semiconducting photothermal agent (PAQI-BDTT) for therapy. To achieve this, PAQI-BDTT was encapsulated within liposomes modified with cyclic...
Multifunctional theranostics play a critical role in improving the efficacy of photothermal therapy and tumor fluorescence imaging; however, they require integration complex components into single theranostic system, their response second near-infrared (NIR-II) region is constrained by wavelengths photosensitizer. To address this issue, we herein developed novel multifunctional thiazole-fused quinoxalineimide semiconducting polymer (named PQIA-BDTT), which exhibits NIR-II properties....
Abstract Phototherapy promotes anti‐tumor immunity by inducing immunogenic cell death (ICD), However, the accompanying inflammatory responses also trigger immunosuppression, attenuating efficacy of photo‐immunotherapy. Herein, they co‐assembled a cell‐membrane targeting chimeric peptide C16‐Cypate‐RRKK‐PEG 8 ‐COOH (CCP) and anti‐inflammatory diclofenac (DA) to develop nanodrug (CCP@DA) that both enhances immune effect phototherapy weakens inflammation‐mediated immunosuppression. CCP@DA...
Intramolecular [4 + 4] photocycloaddition of a furan and cyclopentane-annulated 2-pyridone yields cyclooctadiene product with four new stereogenic centers. Transannular ring closure produces the 5-5-5-5 fused system crinipellins, including three contiguous quaternary carbons, correct absolute stereochemistry derived from (-)-carvone.
Abstract We report the first example of Pd(II)‐catalyzed highly step‐ and atom‐economical benzofulvenation through free amine‐directed ortho C−H bond activation o ‐arylanilines. This paper presents a novel, simple, efficient approach for synthesis benzofulvene derivatives from ‐arylaniline substrates with two diarylacetylenes as an implicit unit. The reactivity synthesized benzofulvenes toward oxidation was investigated, they were shown to transform into phenanthridines, oxabenzofulvenes,...
A versatile tumor targeting theranostic nanoagent (named T-lipos-CPAuNCs) was introduced to realize multimodal imaging-guided cancer photothermal therapy with suppression of the inflammatory response.
[Structure: see text] Transannular ring closure of a pyridone-furan [4+4] photoadduct has been evaluated in model system. A combination nitrogen substitution and an isopropyl group gave full control the four new stereogenic centers. Chlorination transformed 1,5-cyclooctadiene to [4.2.0] system instead expected [3.3.0] Changing alkene enone suppressed this pathway led rearrangement, converting 5-8-5 6-7-5
An approach to assembling unsymmetrically coupled piperidines is described, involving initial [4 + 4] photocycloaddition of 2-pyridones, followed by Cope rearrangement and retro-Mannich reaction. In these reactions, four stereogenic centers set during cycloaddition are relayed or erased the subsequent steps. Two methods for reaction demonstrated.
This study aims to explore the role of SKA1 in cancer diagnosis and prognosis investigate mechanism by which affects malignant behaviors ovarian cancer. Herein, we analyzed oncogenic at pan-cancer level multiple informatics databases verified analysis vitro experiments. As a result, was upregulated across cancers related poor clinical outcome immune infiltration. Specifically, constructed nomogram showed superior performance predicting epithelial patients. Furthermore, experiments revealed...
Enhanced photothermal therapy performance was achieved for D–A conjugated polymers by manipulating molecular motion.
[reaction: see text] Halogenation of achiral trans-2-pyridone photodimers results in 1,3-migration an amide nitrogen and formation a chiral structure with six stereogenic centers well-differentiated functionality. The reactivity this product toward nucleophiles, including the allylic halide, is dominated by participation nitrogen.
Two-photon fluorescence bioimaging holds immense promise for deep tissue imaging.
Energy consumption modeling constitutes an imperative step towards improving energy efficiency of smart buildings. In this context, conventional static methods are not fully accurate, since the is generally affected by multiple time-dependent factors. order to address limitation, paper proposes a dynamic method based on cyber-physical fusion techniques. First, physical model simulation involving time windows constructed. Second, combined with analysis key processes and real scenarios, heat...
Abstract Objectives: We performed a retrospective cross-sectional study to determine the characteristics and risk factors for postoperative mortality in children who underwent CHD surgery. Design: A study. Setting: Guangdong Provincial People’s Hospital from January 1, 2005, December 31, 2020. Patients: All pediatric patients open heart surgery CHD. Interventions: None. Measurements Main Results: Patients’ demographic features, clinical data, preoperative comorbidities complications,...
Photodimerization of 2-pyridones produces primarily a trans tricyclic product with center symmetry.Treatment this chlorine leads to an amide nitrogen migration and formation chiral six stereogenic centers.We have explored the chemistry readily available goal producing stereo-defined acyclic report here preparation crystal structure ten-carbon rich stereochemistry.Opening two bridging lactams has proven be difficult.
Photodimers of 2-pyridones are cycloocta-1,5-dienes with two lactam bridges. These, and related structures, undergo halogenation to give rearranged products in which an amide nitrogen has intercepted initial halonium ion. For the trans isomer, a transient four-membered azetidinium ion reacts via dealkylation, giving dihalide-diamide product high yield. This readily available intermediate nucleophiles process that begins intramolecular N-alkylation, reforming intermediate. Reaction this...